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The role of peptides in bone healing and regeneration: a systematic review.

Pountos I, Panteli M, Lampropoulos A, Jones E, Calori GM, Giannoudis PV - BMC Med (2016)

Bottom Line: Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study.Based on the available literature, a significant amount of experimental in vitro and in vivo evidence exists.Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications.

View Article: PubMed Central - PubMed

Affiliation: Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, Leeds, UK.

ABSTRACT

Background: Bone tissue engineering and the research surrounding peptides has expanded significantly over the last few decades. Several peptides have been shown to support and stimulate the bone healing response and have been proposed as therapeutic vehicles for clinical use. The aim of this comprehensive review is to present the clinical and experimental studies analysing the potential role of peptides for bone healing and bone regeneration.

Methods: A systematic review according to PRISMA guidelines was conducted. Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study.

Results: Based on the available literature, a significant amount of experimental in vitro and in vivo evidence exists. Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications. However, from the available peptides that reached the level of clinical trials, the presented results are limited.

Conclusion: Further research is desirable to shed more light into the processes governing the osteoprogenitor cellular responses. With further advances in the field of biomimetic materials and scaffolds, new treatment modalities for bone repair will emerge.

No MeSH data available.


Flowchart of study selection process
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Related In: Results  -  Collection

License 1 - License 2
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Fig1: Flowchart of study selection process

Mentions: Out of 6017 papers that were initially identified, 197 met the inclusion criteria (Fig. 1) [27–223]. These studies are presented below.Fig. 1


The role of peptides in bone healing and regeneration: a systematic review.

Pountos I, Panteli M, Lampropoulos A, Jones E, Calori GM, Giannoudis PV - BMC Med (2016)

Flowchart of study selection process
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4940902&req=5

Fig1: Flowchart of study selection process
Mentions: Out of 6017 papers that were initially identified, 197 met the inclusion criteria (Fig. 1) [27–223]. These studies are presented below.Fig. 1

Bottom Line: Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study.Based on the available literature, a significant amount of experimental in vitro and in vivo evidence exists.Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications.

View Article: PubMed Central - PubMed

Affiliation: Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, Leeds, UK.

ABSTRACT

Background: Bone tissue engineering and the research surrounding peptides has expanded significantly over the last few decades. Several peptides have been shown to support and stimulate the bone healing response and have been proposed as therapeutic vehicles for clinical use. The aim of this comprehensive review is to present the clinical and experimental studies analysing the potential role of peptides for bone healing and bone regeneration.

Methods: A systematic review according to PRISMA guidelines was conducted. Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study.

Results: Based on the available literature, a significant amount of experimental in vitro and in vivo evidence exists. Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications. However, from the available peptides that reached the level of clinical trials, the presented results are limited.

Conclusion: Further research is desirable to shed more light into the processes governing the osteoprogenitor cellular responses. With further advances in the field of biomimetic materials and scaffolds, new treatment modalities for bone repair will emerge.

No MeSH data available.