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Two cases of food aversion with semantic dementia.

Thompson AE, Clark CN, Hardy CJ, Fletcher PD, Greene J, Rohrer JD, Warren JD - Neurocase (2016)

Bottom Line: Accounts of altered eating behavior in semantic dementia generally emphasize gluttony and abnormal food preferences.Here we describe two female patients with no past history of eating disorders who developed early prominent aversion to food in the context of an otherwise typical semantic dementia syndrome.One patient (aged 57) presented features in line with anorexia nervosa while the second patient (aged 58) presented with a syndrome more suggestive of bulimia nervosa.

View Article: PubMed Central - PubMed

Affiliation: a Dementia Research Centre, UCL Institute of Neurology , University College London , London , UK.

ABSTRACT
Accounts of altered eating behavior in semantic dementia generally emphasize gluttony and abnormal food preferences. Here we describe two female patients with no past history of eating disorders who developed early prominent aversion to food in the context of an otherwise typical semantic dementia syndrome. One patient (aged 57) presented features in line with anorexia nervosa while the second patient (aged 58) presented with a syndrome more suggestive of bulimia nervosa. These cases add to the growing spectrum of apparently dichotomous behavior patterns in the frontotemporal dementias and illustrate a potentially under-recognized cause of eating disorders presenting in later life.

No MeSH data available.


Related in: MedlinePlus

Brain MRI profiles in patients with semantic dementia and food aversion.Representative coronal T1-weighted MR sections through the anterior temporal lobes are presented for each of the patients described; the left hemisphere is shown on the right for both sections. In each case, there is relatively focal, asymmetric atrophy of the anterior temporal lobes, most marked medially and inferiorly (predominantly right-sided though bilateral in Case 1, predominantly left-sided in Case 2).
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Figure 0001: Brain MRI profiles in patients with semantic dementia and food aversion.Representative coronal T1-weighted MR sections through the anterior temporal lobes are presented for each of the patients described; the left hemisphere is shown on the right for both sections. In each case, there is relatively focal, asymmetric atrophy of the anterior temporal lobes, most marked medially and inferiorly (predominantly right-sided though bilateral in Case 1, predominantly left-sided in Case 2).

Mentions: Brain MRI (Figure 1) showed bilateral though asymmetric anterior, medial, and inferior temporal lobe atrophy, more marked in the right cerebral hemisphere. CSF examination showed levels of neurodegeneration marker proteins within the normal ranges for the local laboratory (total tau 321 pg/mL, beta-amyloid1-42 957 pg/mL, ratio tau:amyloid 0.34), making a diagnosis of underlying Alzheimer’s disease pathology unlikely.Figure 1.


Two cases of food aversion with semantic dementia.

Thompson AE, Clark CN, Hardy CJ, Fletcher PD, Greene J, Rohrer JD, Warren JD - Neurocase (2016)

Brain MRI profiles in patients with semantic dementia and food aversion.Representative coronal T1-weighted MR sections through the anterior temporal lobes are presented for each of the patients described; the left hemisphere is shown on the right for both sections. In each case, there is relatively focal, asymmetric atrophy of the anterior temporal lobes, most marked medially and inferiorly (predominantly right-sided though bilateral in Case 1, predominantly left-sided in Case 2).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4940890&req=5

Figure 0001: Brain MRI profiles in patients with semantic dementia and food aversion.Representative coronal T1-weighted MR sections through the anterior temporal lobes are presented for each of the patients described; the left hemisphere is shown on the right for both sections. In each case, there is relatively focal, asymmetric atrophy of the anterior temporal lobes, most marked medially and inferiorly (predominantly right-sided though bilateral in Case 1, predominantly left-sided in Case 2).
Mentions: Brain MRI (Figure 1) showed bilateral though asymmetric anterior, medial, and inferior temporal lobe atrophy, more marked in the right cerebral hemisphere. CSF examination showed levels of neurodegeneration marker proteins within the normal ranges for the local laboratory (total tau 321 pg/mL, beta-amyloid1-42 957 pg/mL, ratio tau:amyloid 0.34), making a diagnosis of underlying Alzheimer’s disease pathology unlikely.Figure 1.

Bottom Line: Accounts of altered eating behavior in semantic dementia generally emphasize gluttony and abnormal food preferences.Here we describe two female patients with no past history of eating disorders who developed early prominent aversion to food in the context of an otherwise typical semantic dementia syndrome.One patient (aged 57) presented features in line with anorexia nervosa while the second patient (aged 58) presented with a syndrome more suggestive of bulimia nervosa.

View Article: PubMed Central - PubMed

Affiliation: a Dementia Research Centre, UCL Institute of Neurology , University College London , London , UK.

ABSTRACT
Accounts of altered eating behavior in semantic dementia generally emphasize gluttony and abnormal food preferences. Here we describe two female patients with no past history of eating disorders who developed early prominent aversion to food in the context of an otherwise typical semantic dementia syndrome. One patient (aged 57) presented features in line with anorexia nervosa while the second patient (aged 58) presented with a syndrome more suggestive of bulimia nervosa. These cases add to the growing spectrum of apparently dichotomous behavior patterns in the frontotemporal dementias and illustrate a potentially under-recognized cause of eating disorders presenting in later life.

No MeSH data available.


Related in: MedlinePlus