Limits...
Efficacy of preoperative biliary drainage in malignant obstructive jaundice: a meta-analysis and systematic review.

Moole H, Bechtold M, Puli SR - World J Surg Oncol (2016)

Bottom Line: Pooled number of major adverse effects was lower in the PBD group at 10.40 (95 % CI = 9.96 to 10.83) compared to 15.56 (95 % CI = 15.06 to 16.05) in the DS group.Subgroup analysis comparing internal PBD to DS group showed lower odds for major adverse events (odds ratio, 0.48 with 95 % CI = 0.32 to 0.74).Length of hospital stay and mortality rate were comparable in both the groups.

View Article: PubMed Central - PubMed

Affiliation: Division of General Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA. harsha1778@yahoo.co.in.

ABSTRACT

Background: In patients requiring surgical resection for malignant biliary jaundice, it is unclear if preoperative biliary drainage (PBD) would improve mortality and morbidity by restoration of biliary flow prior to operation. This is a meta-analysis to pool the evidence and assess the utility of PBD in patients with malignant obstructive jaundice. The primary outcome is comparing mortality outcomes in patients with malignant obstructive jaundice undergoing direct surgery (DS) versus PBD. The secondary outcomes include major adverse events and length of hospital stay in both the groups.

Methods: Studies using PBD in patients with malignant obstructive jaundice were included in this study. For the data collection and extraction, articles were searched in MEDLINE, PubMed, Embase, Cochrane Central Register of Controlled Trials & Database of Systematic Reviews, etc. Pooled proportions were calculated using both Mantel-Haenszel method (fixed effects model) and DerSimonian-Laird method (random effects model).

Results: Initial search identified 2230 reference articles, of which 204 were selected and reviewed. Twenty-six studies (N = 3532) for PBD in malignant obstructive jaundice which met the inclusion criteria were included in this analysis. The odds ratio for mortality in PBD group versus DS group was 0.96 (95 % CI = 0.71 to 1.29). Pooled number of major adverse effects was lower in the PBD group at 10.40 (95 % CI = 9.96 to 10.83) compared to 15.56 (95 % CI = 15.06 to 16.05) in the DS group. Subgroup analysis comparing internal PBD to DS group showed lower odds for major adverse events (odds ratio, 0.48 with 95 % CI = 0.32 to 0.74).

Conclusions: In patients with malignant biliary jaundice requiring surgery, PBD group had significantly less major adverse effects than DS group. Length of hospital stay and mortality rate were comparable in both the groups.

No MeSH data available.


Related in: MedlinePlus

Funnel plot for publication bias assessment (odds ratio for mortality)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4940848&req=5

Fig3: Funnel plot for publication bias assessment (odds ratio for mortality)

Mentions: The odds of mortality in the preoperative biliary drainage group compared to direct surgery group was 0.96 (95 % CI = 0.71 to 1.29). Figure 2 shows the forest plot showing odds in individual studies. Publication bias calculated using Harbord-Egger bias indicator gave a value of −1.04 (95 % CI = −2.22 to 0.15, p = 0.08). The Begg-Mazumdar indicator gave a Kendall’s tau b value of −0.23 (p = 0.14). Figure 3 shows the funnel plot for bias. The agreement between reviewers for the collected data gave a Cohen’s k value of 1.0.Fig. 2


Efficacy of preoperative biliary drainage in malignant obstructive jaundice: a meta-analysis and systematic review.

Moole H, Bechtold M, Puli SR - World J Surg Oncol (2016)

Funnel plot for publication bias assessment (odds ratio for mortality)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4940848&req=5

Fig3: Funnel plot for publication bias assessment (odds ratio for mortality)
Mentions: The odds of mortality in the preoperative biliary drainage group compared to direct surgery group was 0.96 (95 % CI = 0.71 to 1.29). Figure 2 shows the forest plot showing odds in individual studies. Publication bias calculated using Harbord-Egger bias indicator gave a value of −1.04 (95 % CI = −2.22 to 0.15, p = 0.08). The Begg-Mazumdar indicator gave a Kendall’s tau b value of −0.23 (p = 0.14). Figure 3 shows the funnel plot for bias. The agreement between reviewers for the collected data gave a Cohen’s k value of 1.0.Fig. 2

Bottom Line: Pooled number of major adverse effects was lower in the PBD group at 10.40 (95 % CI = 9.96 to 10.83) compared to 15.56 (95 % CI = 15.06 to 16.05) in the DS group.Subgroup analysis comparing internal PBD to DS group showed lower odds for major adverse events (odds ratio, 0.48 with 95 % CI = 0.32 to 0.74).Length of hospital stay and mortality rate were comparable in both the groups.

View Article: PubMed Central - PubMed

Affiliation: Division of General Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA. harsha1778@yahoo.co.in.

ABSTRACT

Background: In patients requiring surgical resection for malignant biliary jaundice, it is unclear if preoperative biliary drainage (PBD) would improve mortality and morbidity by restoration of biliary flow prior to operation. This is a meta-analysis to pool the evidence and assess the utility of PBD in patients with malignant obstructive jaundice. The primary outcome is comparing mortality outcomes in patients with malignant obstructive jaundice undergoing direct surgery (DS) versus PBD. The secondary outcomes include major adverse events and length of hospital stay in both the groups.

Methods: Studies using PBD in patients with malignant obstructive jaundice were included in this study. For the data collection and extraction, articles were searched in MEDLINE, PubMed, Embase, Cochrane Central Register of Controlled Trials & Database of Systematic Reviews, etc. Pooled proportions were calculated using both Mantel-Haenszel method (fixed effects model) and DerSimonian-Laird method (random effects model).

Results: Initial search identified 2230 reference articles, of which 204 were selected and reviewed. Twenty-six studies (N = 3532) for PBD in malignant obstructive jaundice which met the inclusion criteria were included in this analysis. The odds ratio for mortality in PBD group versus DS group was 0.96 (95 % CI = 0.71 to 1.29). Pooled number of major adverse effects was lower in the PBD group at 10.40 (95 % CI = 9.96 to 10.83) compared to 15.56 (95 % CI = 15.06 to 16.05) in the DS group. Subgroup analysis comparing internal PBD to DS group showed lower odds for major adverse events (odds ratio, 0.48 with 95 % CI = 0.32 to 0.74).

Conclusions: In patients with malignant biliary jaundice requiring surgery, PBD group had significantly less major adverse effects than DS group. Length of hospital stay and mortality rate were comparable in both the groups.

No MeSH data available.


Related in: MedlinePlus