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Non-malaria fevers in a high malaria endemic area of Ghana.

Asante KP, Owusu-Agyei S, Cairns M, Boamah E, Manu G, Twumasi M, Gyasi R, Adjei G, Kayan K, Mahama E, Dosoo DK, Koram K, Greenwood B, Chandramohan D - BMC Infect. Dis. (2016)

Bottom Line: The incidence of all episodes of NMF in the first year of life (first and subsequent) was 1.60 per child-year (95 % CI 1.54, 1.66).The incidence of NMF was higher among infants with low birth weight [adjusted hazard ratio (aHR) 1.22 (95 % CI 1.04-1.42) p = 0.012], infants from households of poor socio-economic status [aHR 1.22 (95 % CI 1.02-1.46) p = 0.027] and infants living furthest from a health facility [aHR 1.20 (95 % CI 1.01-1.43) p = 0.037].The incidence of NMF in infancy is high in the study area.

View Article: PubMed Central - PubMed

Affiliation: Kintampo Health Research Centre, Ghana Health Service, P. O. Box, 200, Kintampo, Brong Ahafo Region, Ghana. kwakupoku.asante@kintampo-hrc.org.

ABSTRACT

Background: The importance of fevers not due to malaria [non-malaria fevers, NMFs] in children in sub-Saharan Africa is increasingly being recognised. We have investigated the influence of exposure-related factors and placental malaria on the risk of non-malaria fevers among children in Kintampo, an area of Ghana with high malaria transmission.

Methods: Between 2008 and 2011, a cohort of 1855 newborns was enrolled and followed for at least 12 months. Episodes of illness were detected by passive case detection. The primary analysis covered the period from birth up to 12 months of age, with an exploratory analysis of a sub-group of children followed for up to 24 months.

Results: The incidence of all episodes of NMF in the first year of life (first and subsequent) was 1.60 per child-year (95 % CI 1.54, 1.66). The incidence of NMF was higher among infants with low birth weight [adjusted hazard ratio (aHR) 1.22 (95 % CI 1.04-1.42) p = 0.012], infants from households of poor socio-economic status [aHR 1.22 (95 % CI 1.02-1.46) p = 0.027] and infants living furthest from a health facility [aHR 1.20 (95 % CI 1.01-1.43) p = 0.037]. The incidence of all episodes of NMF was similar among infants born to mothers with or without placental malaria [aHR 0.97 (0.87, 1.08; p = 0.584)].

Conclusion: The incidence of NMF in infancy is high in the study area. The incidence of NMF is associated with low birth weight and poor socioeconomic status but not with placental malaria.

No MeSH data available.


Related in: MedlinePlus

Study flow diagram of infants born into the Kintampo Birth Cohort Study. *The cohort included 72 children from twin pregnancies
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Fig1: Study flow diagram of infants born into the Kintampo Birth Cohort Study. *The cohort included 72 children from twin pregnancies

Mentions: A cohort of 1855 newborns was recruited and followed; 79.5 % (1475) completed the scheduled 1 year of follow up. Additionally, 39.5 % (737) and 17.4 % (322) were followed for 18 and 24 months respectively (Fig. 1). Six hundred and ninety-five infants (37.5 %) were born to mothers with placental malaria (PM) (PM + ve children), 355 (19 %) to primigravidae (PG) and 1050 (57 %) to mothers who had taken all three scheduled doses of IPTp (Table 1). The majority of infants (1465, 78.9 %) lived in rural areas. The prevalence of LBW was 40/508 (7.87 %) in the dry season and 130/1308 (9.9 %) in the wet season (p = 0.175). Socio-demographic characteristics such are place of residence, household size, or socioeconomic status were not statistically different among children who died and children who survived (Table 2). Perinatal deaths were the main cause of death among children with a known cause of deaths (Table 3).Fig. 1


Non-malaria fevers in a high malaria endemic area of Ghana.

Asante KP, Owusu-Agyei S, Cairns M, Boamah E, Manu G, Twumasi M, Gyasi R, Adjei G, Kayan K, Mahama E, Dosoo DK, Koram K, Greenwood B, Chandramohan D - BMC Infect. Dis. (2016)

Study flow diagram of infants born into the Kintampo Birth Cohort Study. *The cohort included 72 children from twin pregnancies
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4940727&req=5

Fig1: Study flow diagram of infants born into the Kintampo Birth Cohort Study. *The cohort included 72 children from twin pregnancies
Mentions: A cohort of 1855 newborns was recruited and followed; 79.5 % (1475) completed the scheduled 1 year of follow up. Additionally, 39.5 % (737) and 17.4 % (322) were followed for 18 and 24 months respectively (Fig. 1). Six hundred and ninety-five infants (37.5 %) were born to mothers with placental malaria (PM) (PM + ve children), 355 (19 %) to primigravidae (PG) and 1050 (57 %) to mothers who had taken all three scheduled doses of IPTp (Table 1). The majority of infants (1465, 78.9 %) lived in rural areas. The prevalence of LBW was 40/508 (7.87 %) in the dry season and 130/1308 (9.9 %) in the wet season (p = 0.175). Socio-demographic characteristics such are place of residence, household size, or socioeconomic status were not statistically different among children who died and children who survived (Table 2). Perinatal deaths were the main cause of death among children with a known cause of deaths (Table 3).Fig. 1

Bottom Line: The incidence of all episodes of NMF in the first year of life (first and subsequent) was 1.60 per child-year (95 % CI 1.54, 1.66).The incidence of NMF was higher among infants with low birth weight [adjusted hazard ratio (aHR) 1.22 (95 % CI 1.04-1.42) p = 0.012], infants from households of poor socio-economic status [aHR 1.22 (95 % CI 1.02-1.46) p = 0.027] and infants living furthest from a health facility [aHR 1.20 (95 % CI 1.01-1.43) p = 0.037].The incidence of NMF in infancy is high in the study area.

View Article: PubMed Central - PubMed

Affiliation: Kintampo Health Research Centre, Ghana Health Service, P. O. Box, 200, Kintampo, Brong Ahafo Region, Ghana. kwakupoku.asante@kintampo-hrc.org.

ABSTRACT

Background: The importance of fevers not due to malaria [non-malaria fevers, NMFs] in children in sub-Saharan Africa is increasingly being recognised. We have investigated the influence of exposure-related factors and placental malaria on the risk of non-malaria fevers among children in Kintampo, an area of Ghana with high malaria transmission.

Methods: Between 2008 and 2011, a cohort of 1855 newborns was enrolled and followed for at least 12 months. Episodes of illness were detected by passive case detection. The primary analysis covered the period from birth up to 12 months of age, with an exploratory analysis of a sub-group of children followed for up to 24 months.

Results: The incidence of all episodes of NMF in the first year of life (first and subsequent) was 1.60 per child-year (95 % CI 1.54, 1.66). The incidence of NMF was higher among infants with low birth weight [adjusted hazard ratio (aHR) 1.22 (95 % CI 1.04-1.42) p = 0.012], infants from households of poor socio-economic status [aHR 1.22 (95 % CI 1.02-1.46) p = 0.027] and infants living furthest from a health facility [aHR 1.20 (95 % CI 1.01-1.43) p = 0.037]. The incidence of all episodes of NMF was similar among infants born to mothers with or without placental malaria [aHR 0.97 (0.87, 1.08; p = 0.584)].

Conclusion: The incidence of NMF in infancy is high in the study area. The incidence of NMF is associated with low birth weight and poor socioeconomic status but not with placental malaria.

No MeSH data available.


Related in: MedlinePlus