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From Traditional Usage to Pharmacological Evidence: A Systematic Mini-Review of Spina Gleditsiae.

Gao J, Yang X, Yin W - Evid Based Complement Alternat Med (2016)

Bottom Line: In China through the centuries, it has been traditionally used as a source of drugs for anticancer, detoxication, detumescence, apocenosis, and antiparasites effects.Recently, an increasing number of studies have been reported regarding its chemical constituents and pharmacological activities.According to the reviewed data, it is quite evident that Spina Gleditsiae contains a number of bioactive phytochemical components, which account for variety medicinal values including anticancer, anti-inflammatory, antiatherogenic, antimicrobial, antiallergic, and antivirus activities.

View Article: PubMed Central - PubMed

Affiliation: School of Chemical Engineering and Pharmaceutics, Henan University of Science & Technology, Luoyang, Henan 471023, China.

ABSTRACT
Spina Gleditsiae is an important herb with various medicinal properties in traditional and folk medicinal systems of East Asian countries. In China through the centuries, it has been traditionally used as a source of drugs for anticancer, detoxication, detumescence, apocenosis, and antiparasites effects. Recently, an increasing number of studies have been reported regarding its chemical constituents and pharmacological activities. To further evidence the traditional use, phytochemicals, and pharmacological mechanisms of this herb, a systematic literature review was performed herein for Spina Gleditsiae. The review approach consisted of searching several web-based scientific databases including PubMed, Web of Science, and Elsevier using the keywords "Spina Gleditsiae", "Zao Jiao Ci", and "Gleditsia sinensis". Based on the proposed criteria, 17 articles were evaluated in detail. According to the reviewed data, it is quite evident that Spina Gleditsiae contains a number of bioactive phytochemical components, which account for variety medicinal values including anticancer, anti-inflammatory, antiatherogenic, antimicrobial, antiallergic, and antivirus activities. The phytochemical and pharmacological studies reviewed herein strongly underpin a fundamental understanding of herbal Spina Gleditsiae and support its ongoing clinical uses in China. The further phytochemical evaluation, safety verification, and clinical trials are expected to progress Spina Gleditsiae-based development to finally transform the traditional TCM herb Spina Gleditsiae to the valuable authorized drug.

No MeSH data available.


Compounds isolated from Spina Gleditsiae.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4940578&req=5

fig1: Compounds isolated from Spina Gleditsiae.

Mentions: Spina Gleditsiae is rich in secondary metabolites, which are discovered to be responsible for exhibiting its medicinal activities. So far, there are totally 30 compounds belonging to five major groups of secondary metabolites, including triterpene, sterol, flavonoid, phenolic, and alkaloid, which have been isolated and elucidated from Spina Gleditsiae. The chemical structures, previously reported from this herbal medicine, are shown in Figure 1.


From Traditional Usage to Pharmacological Evidence: A Systematic Mini-Review of Spina Gleditsiae.

Gao J, Yang X, Yin W - Evid Based Complement Alternat Med (2016)

Compounds isolated from Spina Gleditsiae.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4940578&req=5

fig1: Compounds isolated from Spina Gleditsiae.
Mentions: Spina Gleditsiae is rich in secondary metabolites, which are discovered to be responsible for exhibiting its medicinal activities. So far, there are totally 30 compounds belonging to five major groups of secondary metabolites, including triterpene, sterol, flavonoid, phenolic, and alkaloid, which have been isolated and elucidated from Spina Gleditsiae. The chemical structures, previously reported from this herbal medicine, are shown in Figure 1.

Bottom Line: In China through the centuries, it has been traditionally used as a source of drugs for anticancer, detoxication, detumescence, apocenosis, and antiparasites effects.Recently, an increasing number of studies have been reported regarding its chemical constituents and pharmacological activities.According to the reviewed data, it is quite evident that Spina Gleditsiae contains a number of bioactive phytochemical components, which account for variety medicinal values including anticancer, anti-inflammatory, antiatherogenic, antimicrobial, antiallergic, and antivirus activities.

View Article: PubMed Central - PubMed

Affiliation: School of Chemical Engineering and Pharmaceutics, Henan University of Science & Technology, Luoyang, Henan 471023, China.

ABSTRACT
Spina Gleditsiae is an important herb with various medicinal properties in traditional and folk medicinal systems of East Asian countries. In China through the centuries, it has been traditionally used as a source of drugs for anticancer, detoxication, detumescence, apocenosis, and antiparasites effects. Recently, an increasing number of studies have been reported regarding its chemical constituents and pharmacological activities. To further evidence the traditional use, phytochemicals, and pharmacological mechanisms of this herb, a systematic literature review was performed herein for Spina Gleditsiae. The review approach consisted of searching several web-based scientific databases including PubMed, Web of Science, and Elsevier using the keywords "Spina Gleditsiae", "Zao Jiao Ci", and "Gleditsia sinensis". Based on the proposed criteria, 17 articles were evaluated in detail. According to the reviewed data, it is quite evident that Spina Gleditsiae contains a number of bioactive phytochemical components, which account for variety medicinal values including anticancer, anti-inflammatory, antiatherogenic, antimicrobial, antiallergic, and antivirus activities. The phytochemical and pharmacological studies reviewed herein strongly underpin a fundamental understanding of herbal Spina Gleditsiae and support its ongoing clinical uses in China. The further phytochemical evaluation, safety verification, and clinical trials are expected to progress Spina Gleditsiae-based development to finally transform the traditional TCM herb Spina Gleditsiae to the valuable authorized drug.

No MeSH data available.