Limits...
Static and Dynamic Measurement of Ocular Surface Temperature in Dry Eyes.

Tan LL, Sanjay S, Morgan PB - J Ophthalmol (2016)

Bottom Line: Dynamic measures were study of mean change and net change in OST over 10 s of sustained eye opening.Results.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: School of Chemical and Life Sciences, Singapore Polytechnic, Singapore 139651.

ABSTRACT
Purpose. To study ocular surface temperature (OST) in dry eyes by static and dynamic measures. Methods. OST was recorded on 62 dry eyes and 63 age- and sex-matched controls. Static measures were study of absolute OST at t = 0, 5, and 10 s after eye opening. Dynamic measures were study of mean change and net change in OST over 10 s of sustained eye opening. Ten OST indices studied were temperatures of the geometric center of the cornea (GCC), extreme temporal (T1) and nasal conjunctiva (T4), midtemporal (CT) and nasal conjunctiva (CN), temporal (LT) and nasal (LN) limbus, and mean (MOST), maximum (Max T), and minimum (Min T) temperatures of the region of interest. Results. For static measures, dry eyes recorded significantly lower GCC, MOST, Min T, Max T, T4, CT, LT, LN, and CN. For dynamic measures, dry eyes had significantly steeper regression line of mean change (corresponding to greater net change) for Max T 5 s onward and T4 at 3 s onward. Conclusions. Both static and dynamic measures of the OST were valuable and can be used as clinical tool to assess dry eye.

No MeSH data available.


Related in: MedlinePlus

(Dynamic measures) graphs showing the mean change OST (relative to baseline) during the 10 s sustained eye opening: (a) GCC and MOST; (b) Min T and Max T; (c) T1; (d) T4; (e) CT and LT; (f) CN and LN in (solid circles) dry eye subjects and (open circles) controls. Values in boxes represent the cooling rate and net change in OST over the 10 s period in dry eye and control groups, respectively. A comparison of mean at each 1 s interval was performed using unpaired t-test, ∗p < 0.05. A typical standard deviation for GCC was ±0.29 (= average std deviation) for dry eye and ±0.30 for controls and for MOST it was ±0.15 for dry eye and ±0.18 for controls. A typical standard deviation for Min T was ±0.33 for dry eye and ±0.32 for controls and for Max T it was ±0.11 for dry eye and ±0.13 for controls. A typical standard deviation for T1 was ±0.14 for dry eye and ±0.11 for controls and for T4 it was ±0.21 for dry eye and ±0.16 for controls. A typical standard deviation for CT was ±0.19 for dry eye and ±0.17 for controls and for LT it was ±0.23 for dry eye and ±0.29 for controls. A typical standard deviation for CN was ±0.14 for dry eye and ±0.16 for controls and for LN it was ±0.22 for dry eye and ±0.23 for controls.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4940548&req=5

fig3: (Dynamic measures) graphs showing the mean change OST (relative to baseline) during the 10 s sustained eye opening: (a) GCC and MOST; (b) Min T and Max T; (c) T1; (d) T4; (e) CT and LT; (f) CN and LN in (solid circles) dry eye subjects and (open circles) controls. Values in boxes represent the cooling rate and net change in OST over the 10 s period in dry eye and control groups, respectively. A comparison of mean at each 1 s interval was performed using unpaired t-test, ∗p < 0.05. A typical standard deviation for GCC was ±0.29 (= average std deviation) for dry eye and ±0.30 for controls and for MOST it was ±0.15 for dry eye and ±0.18 for controls. A typical standard deviation for Min T was ±0.33 for dry eye and ±0.32 for controls and for Max T it was ±0.11 for dry eye and ±0.13 for controls. A typical standard deviation for T1 was ±0.14 for dry eye and ±0.11 for controls and for T4 it was ±0.21 for dry eye and ±0.16 for controls. A typical standard deviation for CT was ±0.19 for dry eye and ±0.17 for controls and for LT it was ±0.23 for dry eye and ±0.29 for controls. A typical standard deviation for CN was ±0.14 for dry eye and ±0.16 for controls and for LN it was ±0.22 for dry eye and ±0.23 for controls.

Mentions: For dynamic measures, dry eye had significantly steeper regression line of mean change (corresponding to greater net change) only for two out of the ten OST indices: Max T and T4 (Figure 3). Two-way analysis of variance showed that there were significant group by time interaction effects for Max T and T4 temperatures (Max T: F = 4.6814, p = 0.0324; T4: F = 5.9506, p = 0.0161). For Max T, the drop in mean change in dry eye was statistically significant from 5 s onward (unpaired t-test, 5 s, p = 0.037; 6 s, p = 0.012; 7 s, p = 0.022; 8 s, p = 0.023; 9 s, p = 0.016; 10 s, p = 0.019). Net change for Max T in dry eye over 10 s was −0.17 ± 0.17°C, which was two times greater as compared to controls (−0.09 ± 0.21°C). Cooling rate as indicated by gradient of the graph for Max T was also twice as much as in dry eye (−0.0164°C/s) as compared to controls (−0.0072°C/s) (Figure 3). For T4, the drop in mean change has only happened in dry eye group and it was statistically significant from 3 s onward (unpaired t-test, 3 s, p = 0.023; 4 s, p = 0.005; 5 s, p = 0.014; 6 s, p = 0.009; 7 s, p = 0.047; 8 s, p = 0.036; 9 s, p = 0.028; 10 s, p = 0.005). T4 for control group was pretty stable during the 10 s of sustained eye opening. Net change for T4 in dry eye over 10 s was −0.09 ± 0.22°C, which was more than two times greater as compared to controls (−0.04 ± 0.24°C). Cooling rate for T4 was also more than two times greater in dry eye (−0.0091°C/s) as compared to controls (−0.0039°C/s). No significant differences were found in mean change at any point of time (unpaired t-test at each 1 s interval, p > 0.05) between the two groups for other OST indices during dynamic measures (Figure 3).


Static and Dynamic Measurement of Ocular Surface Temperature in Dry Eyes.

Tan LL, Sanjay S, Morgan PB - J Ophthalmol (2016)

(Dynamic measures) graphs showing the mean change OST (relative to baseline) during the 10 s sustained eye opening: (a) GCC and MOST; (b) Min T and Max T; (c) T1; (d) T4; (e) CT and LT; (f) CN and LN in (solid circles) dry eye subjects and (open circles) controls. Values in boxes represent the cooling rate and net change in OST over the 10 s period in dry eye and control groups, respectively. A comparison of mean at each 1 s interval was performed using unpaired t-test, ∗p < 0.05. A typical standard deviation for GCC was ±0.29 (= average std deviation) for dry eye and ±0.30 for controls and for MOST it was ±0.15 for dry eye and ±0.18 for controls. A typical standard deviation for Min T was ±0.33 for dry eye and ±0.32 for controls and for Max T it was ±0.11 for dry eye and ±0.13 for controls. A typical standard deviation for T1 was ±0.14 for dry eye and ±0.11 for controls and for T4 it was ±0.21 for dry eye and ±0.16 for controls. A typical standard deviation for CT was ±0.19 for dry eye and ±0.17 for controls and for LT it was ±0.23 for dry eye and ±0.29 for controls. A typical standard deviation for CN was ±0.14 for dry eye and ±0.16 for controls and for LN it was ±0.22 for dry eye and ±0.23 for controls.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4940548&req=5

fig3: (Dynamic measures) graphs showing the mean change OST (relative to baseline) during the 10 s sustained eye opening: (a) GCC and MOST; (b) Min T and Max T; (c) T1; (d) T4; (e) CT and LT; (f) CN and LN in (solid circles) dry eye subjects and (open circles) controls. Values in boxes represent the cooling rate and net change in OST over the 10 s period in dry eye and control groups, respectively. A comparison of mean at each 1 s interval was performed using unpaired t-test, ∗p < 0.05. A typical standard deviation for GCC was ±0.29 (= average std deviation) for dry eye and ±0.30 for controls and for MOST it was ±0.15 for dry eye and ±0.18 for controls. A typical standard deviation for Min T was ±0.33 for dry eye and ±0.32 for controls and for Max T it was ±0.11 for dry eye and ±0.13 for controls. A typical standard deviation for T1 was ±0.14 for dry eye and ±0.11 for controls and for T4 it was ±0.21 for dry eye and ±0.16 for controls. A typical standard deviation for CT was ±0.19 for dry eye and ±0.17 for controls and for LT it was ±0.23 for dry eye and ±0.29 for controls. A typical standard deviation for CN was ±0.14 for dry eye and ±0.16 for controls and for LN it was ±0.22 for dry eye and ±0.23 for controls.
Mentions: For dynamic measures, dry eye had significantly steeper regression line of mean change (corresponding to greater net change) only for two out of the ten OST indices: Max T and T4 (Figure 3). Two-way analysis of variance showed that there were significant group by time interaction effects for Max T and T4 temperatures (Max T: F = 4.6814, p = 0.0324; T4: F = 5.9506, p = 0.0161). For Max T, the drop in mean change in dry eye was statistically significant from 5 s onward (unpaired t-test, 5 s, p = 0.037; 6 s, p = 0.012; 7 s, p = 0.022; 8 s, p = 0.023; 9 s, p = 0.016; 10 s, p = 0.019). Net change for Max T in dry eye over 10 s was −0.17 ± 0.17°C, which was two times greater as compared to controls (−0.09 ± 0.21°C). Cooling rate as indicated by gradient of the graph for Max T was also twice as much as in dry eye (−0.0164°C/s) as compared to controls (−0.0072°C/s) (Figure 3). For T4, the drop in mean change has only happened in dry eye group and it was statistically significant from 3 s onward (unpaired t-test, 3 s, p = 0.023; 4 s, p = 0.005; 5 s, p = 0.014; 6 s, p = 0.009; 7 s, p = 0.047; 8 s, p = 0.036; 9 s, p = 0.028; 10 s, p = 0.005). T4 for control group was pretty stable during the 10 s of sustained eye opening. Net change for T4 in dry eye over 10 s was −0.09 ± 0.22°C, which was more than two times greater as compared to controls (−0.04 ± 0.24°C). Cooling rate for T4 was also more than two times greater in dry eye (−0.0091°C/s) as compared to controls (−0.0039°C/s). No significant differences were found in mean change at any point of time (unpaired t-test at each 1 s interval, p > 0.05) between the two groups for other OST indices during dynamic measures (Figure 3).

Bottom Line: Dynamic measures were study of mean change and net change in OST over 10 s of sustained eye opening.Results.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: School of Chemical and Life Sciences, Singapore Polytechnic, Singapore 139651.

ABSTRACT
Purpose. To study ocular surface temperature (OST) in dry eyes by static and dynamic measures. Methods. OST was recorded on 62 dry eyes and 63 age- and sex-matched controls. Static measures were study of absolute OST at t = 0, 5, and 10 s after eye opening. Dynamic measures were study of mean change and net change in OST over 10 s of sustained eye opening. Ten OST indices studied were temperatures of the geometric center of the cornea (GCC), extreme temporal (T1) and nasal conjunctiva (T4), midtemporal (CT) and nasal conjunctiva (CN), temporal (LT) and nasal (LN) limbus, and mean (MOST), maximum (Max T), and minimum (Min T) temperatures of the region of interest. Results. For static measures, dry eyes recorded significantly lower GCC, MOST, Min T, Max T, T4, CT, LT, LN, and CN. For dynamic measures, dry eyes had significantly steeper regression line of mean change (corresponding to greater net change) for Max T 5 s onward and T4 at 3 s onward. Conclusions. Both static and dynamic measures of the OST were valuable and can be used as clinical tool to assess dry eye.

No MeSH data available.


Related in: MedlinePlus