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The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis.

Mirsaeidi M, Omar HR, Ebrahimi G, Campos M - Int J Hypertens (2016)

Bottom Line: ESR was highly associated with sHTN.The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001).With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017).

View Article: PubMed Central - PubMed

Affiliation: Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, FL, USA.

ABSTRACT
Introduction. The association between the level of systemic inflammation and systemic hypertension (sHTN) among subjects with sarcoidosis has not been previously explored. Methods. A retrospective study was conducted to investigate the relation between the level of systemic inflammation in sarcoidosis, measured by various serum inflammatory markers, and sHTN. Results. Among a total of 108 cases with sarcoidosis (mean age: 53.4 years, 76.9% females), 55 (50.9%) had sHTN and 53 (49.1%) were normotensive. ESR was highly associated with sHTN. The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001). ROC curve analysis for ESR revealed an AUC value of 0.795 (95% CI: 0.692-0.897; P = 0.0001). With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017). ROC curve analysis for CRP revealed an AUC value of 0.644 (95% CI: 0.518-0.769; P = 0.03). On multivariate analysis, ESR and the CRP remained independent predictors for sHTN among subjects with sarcoidosis. Conclusion. Systemic inflammation is associated with the presence of sHTN in sarcoidosis.

No MeSH data available.


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Forest plot of multivariate logistic regression analysis demonstrating independent factors associated with systemic hypertension in sarcoidosis patients. Hosmer and Lemeshow P = 0.775.
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fig3: Forest plot of multivariate logistic regression analysis demonstrating independent factors associated with systemic hypertension in sarcoidosis patients. Hosmer and Lemeshow P = 0.775.

Mentions: Multivariate logistic regression analysis with backward stepwise elimination did not change the positive dose-response relationship between the ESR and CRP levels and the prevalence of sHTN. In the multivariate logistic regression model (N = 70, Nagelkerke R2 = 0.332, and P from Hosmer and Lemeshow = 0.775), we found that having ESR levels in the 3rd and 4th quartiles combined (OR 3.165, 95% confidence interval 1.044–9.593, P = 0.042) and CRP levels in the 4th quartile (OR 6.057, 95% confidence interval 1.567–23.415, P = 0.009) remained independent predictors for a subject with sarcoidosis to have sHTN after adjustment for age, sex, body mass index, dyslipidemia, sarcoidosis duration, the use of oral steroids, and hypoalbuminemia. We have not found a relationship between other inflammatory markers such as ferritin, 25 OH vitamin D level, and neutrophil-to-lymphocyte ratio and sHTN on univariate or multivariable analysis. The variables used in the multivariate model are shown as a Forest plot (Figure 3).


The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis.

Mirsaeidi M, Omar HR, Ebrahimi G, Campos M - Int J Hypertens (2016)

Forest plot of multivariate logistic regression analysis demonstrating independent factors associated with systemic hypertension in sarcoidosis patients. Hosmer and Lemeshow P = 0.775.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4940541&req=5

fig3: Forest plot of multivariate logistic regression analysis demonstrating independent factors associated with systemic hypertension in sarcoidosis patients. Hosmer and Lemeshow P = 0.775.
Mentions: Multivariate logistic regression analysis with backward stepwise elimination did not change the positive dose-response relationship between the ESR and CRP levels and the prevalence of sHTN. In the multivariate logistic regression model (N = 70, Nagelkerke R2 = 0.332, and P from Hosmer and Lemeshow = 0.775), we found that having ESR levels in the 3rd and 4th quartiles combined (OR 3.165, 95% confidence interval 1.044–9.593, P = 0.042) and CRP levels in the 4th quartile (OR 6.057, 95% confidence interval 1.567–23.415, P = 0.009) remained independent predictors for a subject with sarcoidosis to have sHTN after adjustment for age, sex, body mass index, dyslipidemia, sarcoidosis duration, the use of oral steroids, and hypoalbuminemia. We have not found a relationship between other inflammatory markers such as ferritin, 25 OH vitamin D level, and neutrophil-to-lymphocyte ratio and sHTN on univariate or multivariable analysis. The variables used in the multivariate model are shown as a Forest plot (Figure 3).

Bottom Line: ESR was highly associated with sHTN.The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001).With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017).

View Article: PubMed Central - PubMed

Affiliation: Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, FL, USA.

ABSTRACT
Introduction. The association between the level of systemic inflammation and systemic hypertension (sHTN) among subjects with sarcoidosis has not been previously explored. Methods. A retrospective study was conducted to investigate the relation between the level of systemic inflammation in sarcoidosis, measured by various serum inflammatory markers, and sHTN. Results. Among a total of 108 cases with sarcoidosis (mean age: 53.4 years, 76.9% females), 55 (50.9%) had sHTN and 53 (49.1%) were normotensive. ESR was highly associated with sHTN. The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001). ROC curve analysis for ESR revealed an AUC value of 0.795 (95% CI: 0.692-0.897; P = 0.0001). With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017). ROC curve analysis for CRP revealed an AUC value of 0.644 (95% CI: 0.518-0.769; P = 0.03). On multivariate analysis, ESR and the CRP remained independent predictors for sHTN among subjects with sarcoidosis. Conclusion. Systemic inflammation is associated with the presence of sHTN in sarcoidosis.

No MeSH data available.


Related in: MedlinePlus