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The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis.

Mirsaeidi M, Omar HR, Ebrahimi G, Campos M - Int J Hypertens (2016)

Bottom Line: ESR was highly associated with sHTN.The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001).With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017).

View Article: PubMed Central - PubMed

Affiliation: Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, FL, USA.

ABSTRACT
Introduction. The association between the level of systemic inflammation and systemic hypertension (sHTN) among subjects with sarcoidosis has not been previously explored. Methods. A retrospective study was conducted to investigate the relation between the level of systemic inflammation in sarcoidosis, measured by various serum inflammatory markers, and sHTN. Results. Among a total of 108 cases with sarcoidosis (mean age: 53.4 years, 76.9% females), 55 (50.9%) had sHTN and 53 (49.1%) were normotensive. ESR was highly associated with sHTN. The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001). ROC curve analysis for ESR revealed an AUC value of 0.795 (95% CI: 0.692-0.897; P = 0.0001). With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017). ROC curve analysis for CRP revealed an AUC value of 0.644 (95% CI: 0.518-0.769; P = 0.03). On multivariate analysis, ESR and the CRP remained independent predictors for sHTN among subjects with sarcoidosis. Conclusion. Systemic inflammation is associated with the presence of sHTN in sarcoidosis.

No MeSH data available.


Related in: MedlinePlus

Receiver operating characteristic (ROC) curve to detect the best cutoff value for albumin in the prediction of systemic hypertension in sarcoidosis patients. AUC value of 0.670 (95% CI 0.564–0.776, P = 0.003). An albumin level < 3.3 gm/dL yielded a 35% sensitivity and 87% specificity for predicting systemic hypertension in sarcoidosis patients.
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fig2: Receiver operating characteristic (ROC) curve to detect the best cutoff value for albumin in the prediction of systemic hypertension in sarcoidosis patients. AUC value of 0.670 (95% CI 0.564–0.776, P = 0.003). An albumin level < 3.3 gm/dL yielded a 35% sensitivity and 87% specificity for predicting systemic hypertension in sarcoidosis patients.

Mentions: The median and interquartile range (IQR) of albumin for the entire cohort was 3.7 g/dL (IQR 3.4−4 gm/dL). Sarcoidosis patients with sHTN had a significantly lower mean albumin level compared with normotensives (3.44 versus 3.77 gm/dL, resp., P = 0.004). Opposite to what was observed with ESR and CRP, the prevalence of hypertension significantly decreased along albumin quartiles (1st quartile < 3.4, 2nd quartile 3.4–3.69, 3rd quartile 3.7–4, and 4th quartile > 4 gm/dL), with the crude prevalence rates of sHTN being 70.8%, 52.6%, 48.3%, and 28.6% for the 1st, 2nd, 3rd, and 4th quartile, respectively (P value for the trend = 0.025). Using the Cochran-Mantel-Haenszel method, the OR to have sHTN in the first albumin quartile compared with the 4th albumin quartile was 5.77 (95% CI 1.725–19.287, P = 0.004). ROC curve analysis revealed an AUC value of 0.670 (95% CI 0.564–0.776, P = 0.003) (Figure 2). An albumin level < 3.3 gm/dL yielded a 35% sensitivity and 87% specificity for predicting systemic hypertension in this sarcoidosis cohort.


The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis.

Mirsaeidi M, Omar HR, Ebrahimi G, Campos M - Int J Hypertens (2016)

Receiver operating characteristic (ROC) curve to detect the best cutoff value for albumin in the prediction of systemic hypertension in sarcoidosis patients. AUC value of 0.670 (95% CI 0.564–0.776, P = 0.003). An albumin level < 3.3 gm/dL yielded a 35% sensitivity and 87% specificity for predicting systemic hypertension in sarcoidosis patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4940541&req=5

fig2: Receiver operating characteristic (ROC) curve to detect the best cutoff value for albumin in the prediction of systemic hypertension in sarcoidosis patients. AUC value of 0.670 (95% CI 0.564–0.776, P = 0.003). An albumin level < 3.3 gm/dL yielded a 35% sensitivity and 87% specificity for predicting systemic hypertension in sarcoidosis patients.
Mentions: The median and interquartile range (IQR) of albumin for the entire cohort was 3.7 g/dL (IQR 3.4−4 gm/dL). Sarcoidosis patients with sHTN had a significantly lower mean albumin level compared with normotensives (3.44 versus 3.77 gm/dL, resp., P = 0.004). Opposite to what was observed with ESR and CRP, the prevalence of hypertension significantly decreased along albumin quartiles (1st quartile < 3.4, 2nd quartile 3.4–3.69, 3rd quartile 3.7–4, and 4th quartile > 4 gm/dL), with the crude prevalence rates of sHTN being 70.8%, 52.6%, 48.3%, and 28.6% for the 1st, 2nd, 3rd, and 4th quartile, respectively (P value for the trend = 0.025). Using the Cochran-Mantel-Haenszel method, the OR to have sHTN in the first albumin quartile compared with the 4th albumin quartile was 5.77 (95% CI 1.725–19.287, P = 0.004). ROC curve analysis revealed an AUC value of 0.670 (95% CI 0.564–0.776, P = 0.003) (Figure 2). An albumin level < 3.3 gm/dL yielded a 35% sensitivity and 87% specificity for predicting systemic hypertension in this sarcoidosis cohort.

Bottom Line: ESR was highly associated with sHTN.The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001).With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017).

View Article: PubMed Central - PubMed

Affiliation: Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, FL, USA.

ABSTRACT
Introduction. The association between the level of systemic inflammation and systemic hypertension (sHTN) among subjects with sarcoidosis has not been previously explored. Methods. A retrospective study was conducted to investigate the relation between the level of systemic inflammation in sarcoidosis, measured by various serum inflammatory markers, and sHTN. Results. Among a total of 108 cases with sarcoidosis (mean age: 53.4 years, 76.9% females), 55 (50.9%) had sHTN and 53 (49.1%) were normotensive. ESR was highly associated with sHTN. The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001). ROC curve analysis for ESR revealed an AUC value of 0.795 (95% CI: 0.692-0.897; P = 0.0001). With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017). ROC curve analysis for CRP revealed an AUC value of 0.644 (95% CI: 0.518-0.769; P = 0.03). On multivariate analysis, ESR and the CRP remained independent predictors for sHTN among subjects with sarcoidosis. Conclusion. Systemic inflammation is associated with the presence of sHTN in sarcoidosis.

No MeSH data available.


Related in: MedlinePlus