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The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis.

Mirsaeidi M, Omar HR, Ebrahimi G, Campos M - Int J Hypertens (2016)

Bottom Line: ESR was highly associated with sHTN.The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001).With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017).

View Article: PubMed Central - PubMed

Affiliation: Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, FL, USA.

ABSTRACT
Introduction. The association between the level of systemic inflammation and systemic hypertension (sHTN) among subjects with sarcoidosis has not been previously explored. Methods. A retrospective study was conducted to investigate the relation between the level of systemic inflammation in sarcoidosis, measured by various serum inflammatory markers, and sHTN. Results. Among a total of 108 cases with sarcoidosis (mean age: 53.4 years, 76.9% females), 55 (50.9%) had sHTN and 53 (49.1%) were normotensive. ESR was highly associated with sHTN. The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001). ROC curve analysis for ESR revealed an AUC value of 0.795 (95% CI: 0.692-0.897; P = 0.0001). With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017). ROC curve analysis for CRP revealed an AUC value of 0.644 (95% CI: 0.518-0.769; P = 0.03). On multivariate analysis, ESR and the CRP remained independent predictors for sHTN among subjects with sarcoidosis. Conclusion. Systemic inflammation is associated with the presence of sHTN in sarcoidosis.

No MeSH data available.


Related in: MedlinePlus

Receiver operating characteristic (ROC) curve to detect the best cutoff value for ESR and CRP in the prediction of systemic hypertension in sarcoidosis patients. ESR had an AUC value of 0.795 (95% CI 0.692–0.897, P = 0.0001). A cutoff value for ESR of 30 mm/hr yielded a 62% sensitivity and 80% specificity for predicting systemic hypertension in sarcoidosis patients. With regard to CRP, the AUC value is 0.644 (95% CI 0.518–0.769, P = 0.03). A cutoff value for CRP of 3 mg/L yielded a 37% sensitivity and 95% specificity for predicting systemic hypertension in sarcoidosis patients.
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fig1: Receiver operating characteristic (ROC) curve to detect the best cutoff value for ESR and CRP in the prediction of systemic hypertension in sarcoidosis patients. ESR had an AUC value of 0.795 (95% CI 0.692–0.897, P = 0.0001). A cutoff value for ESR of 30 mm/hr yielded a 62% sensitivity and 80% specificity for predicting systemic hypertension in sarcoidosis patients. With regard to CRP, the AUC value is 0.644 (95% CI 0.518–0.769, P = 0.03). A cutoff value for CRP of 3 mg/L yielded a 37% sensitivity and 95% specificity for predicting systemic hypertension in sarcoidosis patients.

Mentions: Subjects with sHTN had significantly higher mean and median ESR levels (Table 2). Furthermore, the prevalence of sHTN significantly increased from the 1st to the 4th ESR quartile, with crude prevalence rates of sHTN being 10%, 40.9%, 63.2%, and 75%, respectively (P value for the trend = 0.0001). A total of 23 subjects (67.6%) in the sHTN group had ESR levels in the 3rd or 4th higher quartiles, compared with only 11 (32.4%) of the subjects without sHTN (P = 0.002). Using the Cochran-Mantel-Haenszel method, compared to the lowest ESR quartile, the OR to have sHTN were 6.2 (P = 0.034), 15.4 (P = 0.002), and 33.8 (P = 0.0001) for the 2nd, 3rd, and 4th ESR quartiles, respectively. ROC curve analysis performed to detect the best cutoff value for ESR in predicting sHTN in sarcoidosis patients revealed an AUC value of 0.795 (95% CI 0.692–0.897, P = 0.0001) (Figure 1). A cutoff value for ESR of 30 mm/hr yielded a 62% sensitivity and 80% specificity for predicting the presence of sHTN in this sarcoidosis patient cohort.


The Association between ESR and CRP and Systemic Hypertension in Sarcoidosis.

Mirsaeidi M, Omar HR, Ebrahimi G, Campos M - Int J Hypertens (2016)

Receiver operating characteristic (ROC) curve to detect the best cutoff value for ESR and CRP in the prediction of systemic hypertension in sarcoidosis patients. ESR had an AUC value of 0.795 (95% CI 0.692–0.897, P = 0.0001). A cutoff value for ESR of 30 mm/hr yielded a 62% sensitivity and 80% specificity for predicting systemic hypertension in sarcoidosis patients. With regard to CRP, the AUC value is 0.644 (95% CI 0.518–0.769, P = 0.03). A cutoff value for CRP of 3 mg/L yielded a 37% sensitivity and 95% specificity for predicting systemic hypertension in sarcoidosis patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4940541&req=5

fig1: Receiver operating characteristic (ROC) curve to detect the best cutoff value for ESR and CRP in the prediction of systemic hypertension in sarcoidosis patients. ESR had an AUC value of 0.795 (95% CI 0.692–0.897, P = 0.0001). A cutoff value for ESR of 30 mm/hr yielded a 62% sensitivity and 80% specificity for predicting systemic hypertension in sarcoidosis patients. With regard to CRP, the AUC value is 0.644 (95% CI 0.518–0.769, P = 0.03). A cutoff value for CRP of 3 mg/L yielded a 37% sensitivity and 95% specificity for predicting systemic hypertension in sarcoidosis patients.
Mentions: Subjects with sHTN had significantly higher mean and median ESR levels (Table 2). Furthermore, the prevalence of sHTN significantly increased from the 1st to the 4th ESR quartile, with crude prevalence rates of sHTN being 10%, 40.9%, 63.2%, and 75%, respectively (P value for the trend = 0.0001). A total of 23 subjects (67.6%) in the sHTN group had ESR levels in the 3rd or 4th higher quartiles, compared with only 11 (32.4%) of the subjects without sHTN (P = 0.002). Using the Cochran-Mantel-Haenszel method, compared to the lowest ESR quartile, the OR to have sHTN were 6.2 (P = 0.034), 15.4 (P = 0.002), and 33.8 (P = 0.0001) for the 2nd, 3rd, and 4th ESR quartiles, respectively. ROC curve analysis performed to detect the best cutoff value for ESR in predicting sHTN in sarcoidosis patients revealed an AUC value of 0.795 (95% CI 0.692–0.897, P = 0.0001) (Figure 1). A cutoff value for ESR of 30 mm/hr yielded a 62% sensitivity and 80% specificity for predicting the presence of sHTN in this sarcoidosis patient cohort.

Bottom Line: ESR was highly associated with sHTN.The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001).With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017).

View Article: PubMed Central - PubMed

Affiliation: Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, FL, USA.

ABSTRACT
Introduction. The association between the level of systemic inflammation and systemic hypertension (sHTN) among subjects with sarcoidosis has not been previously explored. Methods. A retrospective study was conducted to investigate the relation between the level of systemic inflammation in sarcoidosis, measured by various serum inflammatory markers, and sHTN. Results. Among a total of 108 cases with sarcoidosis (mean age: 53.4 years, 76.9% females), 55 (50.9%) had sHTN and 53 (49.1%) were normotensive. ESR was highly associated with sHTN. The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001). ROC curve analysis for ESR revealed an AUC value of 0.795 (95% CI: 0.692-0.897; P = 0.0001). With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017). ROC curve analysis for CRP revealed an AUC value of 0.644 (95% CI: 0.518-0.769; P = 0.03). On multivariate analysis, ESR and the CRP remained independent predictors for sHTN among subjects with sarcoidosis. Conclusion. Systemic inflammation is associated with the presence of sHTN in sarcoidosis.

No MeSH data available.


Related in: MedlinePlus