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Geographical Distribution and New Situation of Leishmania Species after the Control of Cutaneous Leishmaniasis Foci in Errachidia Province, Morocco, in 2014.

Mohamed Mahmoud el A, Faiza S, Lemine M, Smaine C, Adlaoui el B, Khalid H, Abderrahim S, Hajiba F - Biomed Res Int (2016)

Bottom Line: The number of cases declined sharply and decreased from 3445 cases in 2010 to 8 cases in 2014 following the control action plan interventions.This is the first molecular identification of L. tropica in Errachidia province.The detection of this species after the intensified control measures strategies suggests that it was probably dissipated through the dominance of L. major.

View Article: PubMed Central - PubMed

Affiliation: National Reference Laboratory of Leishmaniasis, National Institute of Hygiene, 27 Avenue Ibn Battuta, Agdal, 11400 Rabat, Morocco; Laboratory of Zoology and General Biology, Faculty of Sciences, Mohammed V University in Rabat, Avenue Ibn Battouta, BP 1014, 10000 Rabat, Morocco.

ABSTRACT
In Errachidia province, the incidence of cutaneous leishmaniasis (CL) has increased over the past decade and it was higher in 2010 (860.34 per 100,000 inhabitants), with 3445 cases. The number of cases declined sharply and decreased from 3445 cases in 2010 to 8 cases in 2014 following the control action plan interventions. The total of patients was diagnosed only on clinical basis and the lesions were considered caused by L. major. The epidemiological study was conducted between 2001 and 2014 and the molecular detection of CL was studied to identify the circulating parasite species in this province by using the ITS1-PCR-RFLP methods. In 2010, the molecular identification of 11 samples revealed the presence of L. major in the most affected circles: Goulmima, Er-Rissani, and Errachidia. In 2014 the molecular characterization of 7 among 8 cases reported in this year showed the presence of L. tropica in Errachidia circle. This is the first molecular identification of L. tropica in Errachidia province. The detection of this species after the intensified control measures strategies suggests that it was probably dissipated through the dominance of L. major.

No MeSH data available.


Related in: MedlinePlus

Evolution of CL cases in Errachidia province showing cumulative number per year for the period 2001 to 2014, with major peak in 2010 [12].
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fig3: Evolution of CL cases in Errachidia province showing cumulative number per year for the period 2001 to 2014, with major peak in 2010 [12].

Mentions: During the period 2001–2014, there were a total of 7653 CL cases notified in Errachidia province. The epidemiologic situation remained stable until the year 2004 with an average of 2 cases per year; over 2007–2014 the number of cases had an exponential increase with fluctuations. Period from 2007 to 2011 has known a great epidemic. The number of cases has decreased slightly in the following years, with a new recrudescence until 8 cases in 2014. The maximum incidence peak was reached in 2010 with 860.34/100,000 inhabitants (3445 cases) (Figure 3). The spatial as well as temporal distribution of CL cases in the four circles of Errachidia province is illustrated in Figure 2. The first recorded CL cases appeared in 2001 towards the end of 2006 (Figure 2(a)). In the following years (2007–2012), the outbreak spread to the north and west of the province towards Sahara in the south and extending to the Algerian border. We observed higher rates of CL (over 1000 cases) in the four circles, while the highest rate for CL was found in northern of the province (Figure 2(b)). Considering its recent control, CL cases dropped to 11 cases for the rest of 2013 (Figure 2(c)). CL case numbers subsequently decreased during 2014; the few cases recorded are located in the north of the province at the Errachidia circle (Figure 2(d)). Among four circles in this province, the temporal and spatial distribution of CL recorded from 2001 to 2014 showed that 79.86% of cases were recorded in Goulmima and Er-Rissani circles (3 urban and 13 rural districts among 29 total districts) and 11.76% and 8.38% were declared, respectively, in Arfoud and Errachidia circles (Figure 4).


Geographical Distribution and New Situation of Leishmania Species after the Control of Cutaneous Leishmaniasis Foci in Errachidia Province, Morocco, in 2014.

Mohamed Mahmoud el A, Faiza S, Lemine M, Smaine C, Adlaoui el B, Khalid H, Abderrahim S, Hajiba F - Biomed Res Int (2016)

Evolution of CL cases in Errachidia province showing cumulative number per year for the period 2001 to 2014, with major peak in 2010 [12].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4940537&req=5

fig3: Evolution of CL cases in Errachidia province showing cumulative number per year for the period 2001 to 2014, with major peak in 2010 [12].
Mentions: During the period 2001–2014, there were a total of 7653 CL cases notified in Errachidia province. The epidemiologic situation remained stable until the year 2004 with an average of 2 cases per year; over 2007–2014 the number of cases had an exponential increase with fluctuations. Period from 2007 to 2011 has known a great epidemic. The number of cases has decreased slightly in the following years, with a new recrudescence until 8 cases in 2014. The maximum incidence peak was reached in 2010 with 860.34/100,000 inhabitants (3445 cases) (Figure 3). The spatial as well as temporal distribution of CL cases in the four circles of Errachidia province is illustrated in Figure 2. The first recorded CL cases appeared in 2001 towards the end of 2006 (Figure 2(a)). In the following years (2007–2012), the outbreak spread to the north and west of the province towards Sahara in the south and extending to the Algerian border. We observed higher rates of CL (over 1000 cases) in the four circles, while the highest rate for CL was found in northern of the province (Figure 2(b)). Considering its recent control, CL cases dropped to 11 cases for the rest of 2013 (Figure 2(c)). CL case numbers subsequently decreased during 2014; the few cases recorded are located in the north of the province at the Errachidia circle (Figure 2(d)). Among four circles in this province, the temporal and spatial distribution of CL recorded from 2001 to 2014 showed that 79.86% of cases were recorded in Goulmima and Er-Rissani circles (3 urban and 13 rural districts among 29 total districts) and 11.76% and 8.38% were declared, respectively, in Arfoud and Errachidia circles (Figure 4).

Bottom Line: The number of cases declined sharply and decreased from 3445 cases in 2010 to 8 cases in 2014 following the control action plan interventions.This is the first molecular identification of L. tropica in Errachidia province.The detection of this species after the intensified control measures strategies suggests that it was probably dissipated through the dominance of L. major.

View Article: PubMed Central - PubMed

Affiliation: National Reference Laboratory of Leishmaniasis, National Institute of Hygiene, 27 Avenue Ibn Battuta, Agdal, 11400 Rabat, Morocco; Laboratory of Zoology and General Biology, Faculty of Sciences, Mohammed V University in Rabat, Avenue Ibn Battouta, BP 1014, 10000 Rabat, Morocco.

ABSTRACT
In Errachidia province, the incidence of cutaneous leishmaniasis (CL) has increased over the past decade and it was higher in 2010 (860.34 per 100,000 inhabitants), with 3445 cases. The number of cases declined sharply and decreased from 3445 cases in 2010 to 8 cases in 2014 following the control action plan interventions. The total of patients was diagnosed only on clinical basis and the lesions were considered caused by L. major. The epidemiological study was conducted between 2001 and 2014 and the molecular detection of CL was studied to identify the circulating parasite species in this province by using the ITS1-PCR-RFLP methods. In 2010, the molecular identification of 11 samples revealed the presence of L. major in the most affected circles: Goulmima, Er-Rissani, and Errachidia. In 2014 the molecular characterization of 7 among 8 cases reported in this year showed the presence of L. tropica in Errachidia circle. This is the first molecular identification of L. tropica in Errachidia province. The detection of this species after the intensified control measures strategies suggests that it was probably dissipated through the dominance of L. major.

No MeSH data available.


Related in: MedlinePlus