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The Effect of Hemoglobin Levels on Mortality in Pediatric Patients with Severe Traumatic Brain Injury.

Yee KF, Walker AM, Gilfoyle E - Can. Respir. J. (2016)

Bottom Line: Multivariable regression analysis revealed that anemia and the administration of packed red blood cells were not associated with adverse outcomes.Factors that were significantly associated with mortality were presence of abusive head trauma, increasing PRISM score, and low GCS after admission.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesia, Foothills Medical Centre, University of Calgary, 1403 29 Street NW, Calgary, AB, Canada T2N 2T9.

ABSTRACT
Objective. There is increasing evidence of adverse outcomes associated with blood transfusions for adult traumatic brain injury patients. However, current evidence suggests that pediatric traumatic brain injury patients may respond to blood transfusions differently on a vascular level. This study examined the influence of blood transfusions and anemia on the outcome of pediatric traumatic brain injury patients. Design. A retrospective cohort analysis of severe pediatric traumatic brain injury (TBI) patients was undertaken to investigate the association between blood transfusions and anemia on patient outcomes. Measurements and Main Results. One hundred and twenty patients with severe traumatic brain injury were identified and included in the analysis. The median Glasgow Coma Scale (GCS) was 6 and the mean hemoglobin (Hgb) on admission was 115.8 g/L. Forty-three percent of patients (43%) received at least one blood transfusion and the mean hemoglobin before transfusion was 80.1 g/L. Multivariable regression analysis revealed that anemia and the administration of packed red blood cells were not associated with adverse outcomes. Factors that were significantly associated with mortality were presence of abusive head trauma, increasing PRISM score, and low GCS after admission. Conclusion. In this single centre retrospective cohort study, there was no association found between anemia, blood transfusions, and hospital mortality in a pediatric traumatic brain injury patient population.

No MeSH data available.


Related in: MedlinePlus

Total number of patients screened and included into the study. TBI: traumatic brain injury. GCS: Glasgow Coma Scale. CNS: central nervous system.
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fig1: Total number of patients screened and included into the study. TBI: traumatic brain injury. GCS: Glasgow Coma Scale. CNS: central nervous system.

Mentions: A total of 466 patients with TBI were screened for possible study inclusion (Figure 1). One hundred and twenty met the inclusion criteria. Fifty-three patients (44%) received blood transfusions. Of these patients, the average number of transfusions was 1.67.


The Effect of Hemoglobin Levels on Mortality in Pediatric Patients with Severe Traumatic Brain Injury.

Yee KF, Walker AM, Gilfoyle E - Can. Respir. J. (2016)

Total number of patients screened and included into the study. TBI: traumatic brain injury. GCS: Glasgow Coma Scale. CNS: central nervous system.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4940517&req=5

fig1: Total number of patients screened and included into the study. TBI: traumatic brain injury. GCS: Glasgow Coma Scale. CNS: central nervous system.
Mentions: A total of 466 patients with TBI were screened for possible study inclusion (Figure 1). One hundred and twenty met the inclusion criteria. Fifty-three patients (44%) received blood transfusions. Of these patients, the average number of transfusions was 1.67.

Bottom Line: Multivariable regression analysis revealed that anemia and the administration of packed red blood cells were not associated with adverse outcomes.Factors that were significantly associated with mortality were presence of abusive head trauma, increasing PRISM score, and low GCS after admission.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesia, Foothills Medical Centre, University of Calgary, 1403 29 Street NW, Calgary, AB, Canada T2N 2T9.

ABSTRACT
Objective. There is increasing evidence of adverse outcomes associated with blood transfusions for adult traumatic brain injury patients. However, current evidence suggests that pediatric traumatic brain injury patients may respond to blood transfusions differently on a vascular level. This study examined the influence of blood transfusions and anemia on the outcome of pediatric traumatic brain injury patients. Design. A retrospective cohort analysis of severe pediatric traumatic brain injury (TBI) patients was undertaken to investigate the association between blood transfusions and anemia on patient outcomes. Measurements and Main Results. One hundred and twenty patients with severe traumatic brain injury were identified and included in the analysis. The median Glasgow Coma Scale (GCS) was 6 and the mean hemoglobin (Hgb) on admission was 115.8 g/L. Forty-three percent of patients (43%) received at least one blood transfusion and the mean hemoglobin before transfusion was 80.1 g/L. Multivariable regression analysis revealed that anemia and the administration of packed red blood cells were not associated with adverse outcomes. Factors that were significantly associated with mortality were presence of abusive head trauma, increasing PRISM score, and low GCS after admission. Conclusion. In this single centre retrospective cohort study, there was no association found between anemia, blood transfusions, and hospital mortality in a pediatric traumatic brain injury patient population.

No MeSH data available.


Related in: MedlinePlus