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Different Alterations of Cerebral Regional Homogeneity in Early-Onset and Late-Onset Parkinson's Disease.

Sheng K, Fang W, Zhu Y, Shuai G, Zou D, Su M, Han Y, Cheng O - Front Aging Neurosci (2016)

Bottom Line: In the comparisons between LOPD and EOPD, EOPD revealed lower ReHo values in the right putamen and higher ReHo values in the left superior frontal gyrus.The ReHo values were negatively correlated with the UPDRS total scores in the right putamen in LOPD, but a correlation between the ReHo value and UPDRS score was not detected in EOPD.Our findings support the notion that age at onset is associated with the distribution of cerebral regional homogeneity in the resting state and suggest that disproportionate putamen alterations are more prominent in patients with a younger age of onset.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, The University Hospital, Chongqing University Chongqing, China.

ABSTRACT

Unlabelled: HIGHLIGHTS Eighteen EOPD, 21 LOPD and 37 age-matched normal control subjects participated in the resting state fMRI scans.Age at onset of PD modulates the distribution of cerebral regional homogeneity during resting state.Disproportionate putamen alterations are more prominent in PD patients with a younger age of onset.

Objective: Early-onset Parkinson's disease (EOPD) is distinct from late-onset PD (LOPD) as it relates to the clinical profile and response to medication. The objective of current paper is to investigate whether characteristics of spontaneous brain activity in the resting state are associated with the age of disease onset.

Methods: We assessed the correlation between neural activity and age-at-onset in a sample of 39 PD patients (18 EOPD and 21 LOPD) and 37 age-matched normal control subjects. Regional homogeneity (ReHo) approaches were employed using ANOVA with two factors: PD and age.

Results: In the comparisons between LOPD and EOPD, EOPD revealed lower ReHo values in the right putamen and higher ReHo values in the left superior frontal gyrus. Compared with age-matched control subjects, EOPD exhibited lower ReHo values in the right putamen and higher ReHo values in the left inferior temporal gyrus; However, LOPD showed lower ReHo values in the right putamen and left insula. The ReHo values were negatively correlated with the UPDRS total scores in the right putamen in LOPD, but a correlation between the ReHo value and UPDRS score was not detected in EOPD.

Conclusions: Our findings support the notion that age at onset is associated with the distribution of cerebral regional homogeneity in the resting state and suggest that disproportionate putamen alterations are more prominent in patients with a younger age of onset.

No MeSH data available.


Related in: MedlinePlus

Statistical maps showing the ReHo differences among patients with EOPD or LOPD and normal controls (P < 0.01, FWE corrected). (A) Compared with LOPD, EOPD showed significantly deceased ReHo values in the right putamen and increased ReHo values in the left superior frontal gyrus. (B) Compared with younger normal controls, EOPD showed significantly deceased ReHo values in the right putamen and increased in the left inferior temporal gyrus. (C) Compared with older normal controls, LOPD exhibited decreased ReHo values in the right putamen and left insula. Red and blue denote higher and lower ReHo values, respectively, and the color bars indicate the T-value from post-hoc analyses between each pair of groups.
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Figure 1: Statistical maps showing the ReHo differences among patients with EOPD or LOPD and normal controls (P < 0.01, FWE corrected). (A) Compared with LOPD, EOPD showed significantly deceased ReHo values in the right putamen and increased ReHo values in the left superior frontal gyrus. (B) Compared with younger normal controls, EOPD showed significantly deceased ReHo values in the right putamen and increased in the left inferior temporal gyrus. (C) Compared with older normal controls, LOPD exhibited decreased ReHo values in the right putamen and left insula. Red and blue denote higher and lower ReHo values, respectively, and the color bars indicate the T-value from post-hoc analyses between each pair of groups.

Mentions: In the post-hoc comparison between early-onset and late-onset PD patients, we observed that EOPD patients showed a significant decrease in the ReHo value in the right putamen and an increase in the ReHo value in the left superior frontal gyrus (p < 0.01, FWE-corrected; Figure 1A). The ReHo value in EOPD patients was lower than that in age-matched controls in the right putamen and higher in left inferior temporal gyrus (p < 0.01, FWE-corrected; Figure 1B). Compared to older normal controls, patients with LOPD exhibited decreased ReHo values in the right putamen and left insula (P < 0.01; FWE-corrected; Figure 1C and Table 2).


Different Alterations of Cerebral Regional Homogeneity in Early-Onset and Late-Onset Parkinson's Disease.

Sheng K, Fang W, Zhu Y, Shuai G, Zou D, Su M, Han Y, Cheng O - Front Aging Neurosci (2016)

Statistical maps showing the ReHo differences among patients with EOPD or LOPD and normal controls (P < 0.01, FWE corrected). (A) Compared with LOPD, EOPD showed significantly deceased ReHo values in the right putamen and increased ReHo values in the left superior frontal gyrus. (B) Compared with younger normal controls, EOPD showed significantly deceased ReHo values in the right putamen and increased in the left inferior temporal gyrus. (C) Compared with older normal controls, LOPD exhibited decreased ReHo values in the right putamen and left insula. Red and blue denote higher and lower ReHo values, respectively, and the color bars indicate the T-value from post-hoc analyses between each pair of groups.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4940400&req=5

Figure 1: Statistical maps showing the ReHo differences among patients with EOPD or LOPD and normal controls (P < 0.01, FWE corrected). (A) Compared with LOPD, EOPD showed significantly deceased ReHo values in the right putamen and increased ReHo values in the left superior frontal gyrus. (B) Compared with younger normal controls, EOPD showed significantly deceased ReHo values in the right putamen and increased in the left inferior temporal gyrus. (C) Compared with older normal controls, LOPD exhibited decreased ReHo values in the right putamen and left insula. Red and blue denote higher and lower ReHo values, respectively, and the color bars indicate the T-value from post-hoc analyses between each pair of groups.
Mentions: In the post-hoc comparison between early-onset and late-onset PD patients, we observed that EOPD patients showed a significant decrease in the ReHo value in the right putamen and an increase in the ReHo value in the left superior frontal gyrus (p < 0.01, FWE-corrected; Figure 1A). The ReHo value in EOPD patients was lower than that in age-matched controls in the right putamen and higher in left inferior temporal gyrus (p < 0.01, FWE-corrected; Figure 1B). Compared to older normal controls, patients with LOPD exhibited decreased ReHo values in the right putamen and left insula (P < 0.01; FWE-corrected; Figure 1C and Table 2).

Bottom Line: In the comparisons between LOPD and EOPD, EOPD revealed lower ReHo values in the right putamen and higher ReHo values in the left superior frontal gyrus.The ReHo values were negatively correlated with the UPDRS total scores in the right putamen in LOPD, but a correlation between the ReHo value and UPDRS score was not detected in EOPD.Our findings support the notion that age at onset is associated with the distribution of cerebral regional homogeneity in the resting state and suggest that disproportionate putamen alterations are more prominent in patients with a younger age of onset.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, The University Hospital, Chongqing University Chongqing, China.

ABSTRACT

Unlabelled: HIGHLIGHTS Eighteen EOPD, 21 LOPD and 37 age-matched normal control subjects participated in the resting state fMRI scans.Age at onset of PD modulates the distribution of cerebral regional homogeneity during resting state.Disproportionate putamen alterations are more prominent in PD patients with a younger age of onset.

Objective: Early-onset Parkinson's disease (EOPD) is distinct from late-onset PD (LOPD) as it relates to the clinical profile and response to medication. The objective of current paper is to investigate whether characteristics of spontaneous brain activity in the resting state are associated with the age of disease onset.

Methods: We assessed the correlation between neural activity and age-at-onset in a sample of 39 PD patients (18 EOPD and 21 LOPD) and 37 age-matched normal control subjects. Regional homogeneity (ReHo) approaches were employed using ANOVA with two factors: PD and age.

Results: In the comparisons between LOPD and EOPD, EOPD revealed lower ReHo values in the right putamen and higher ReHo values in the left superior frontal gyrus. Compared with age-matched control subjects, EOPD exhibited lower ReHo values in the right putamen and higher ReHo values in the left inferior temporal gyrus; However, LOPD showed lower ReHo values in the right putamen and left insula. The ReHo values were negatively correlated with the UPDRS total scores in the right putamen in LOPD, but a correlation between the ReHo value and UPDRS score was not detected in EOPD.

Conclusions: Our findings support the notion that age at onset is associated with the distribution of cerebral regional homogeneity in the resting state and suggest that disproportionate putamen alterations are more prominent in patients with a younger age of onset.

No MeSH data available.


Related in: MedlinePlus