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Disorganization, COMT, and Children's Social Behavior: The Norwegian Hypothesis of Legacy of Disorganized Attachment.

Li Z, Hygen BW, Widaman KF, Berg-Nielsen TS, Wichstrøm L, Belsky J - Front Psychol (2016)

Bottom Line: Hygen et al. (2014) proposed that variation in the Catechol-O-methyl transferase(COMT) Val158Met genotype explains this variation, providing preliminary data to this effect.We offer a conceptual replication, analyzing data on 560 children (males: 275) drawn from the NICHD Study of Early Child Care and Youth Development.As predicted, competitive model-fitting indicated that disorganized infants carrying Met alleles engage in more positive behavior and less negative behavior than other children at age 5 and 11, with the reverse true of Val/Val homozygotes, seemingly consistent with caregiving-controlling and punitive-controlling styles, respectively, but only in the case of maternal and not teacher reports, thereby confirmating a relationship-specific hypothesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Ecology, University of California, Davis Davis, CA, USA.

ABSTRACT
Why is disorganized attachment associated with punitive-controlling behavior in some, but caregiving-controlling in others? Hygen et al. (2014) proposed that variation in the Catechol-O-methyl transferase(COMT) Val158Met genotype explains this variation, providing preliminary data to this effect. We offer a conceptual replication, analyzing data on 560 children (males: 275) drawn from the NICHD Study of Early Child Care and Youth Development. As predicted, competitive model-fitting indicated that disorganized infants carrying Met alleles engage in more positive behavior and less negative behavior than other children at age 5 and 11, with the reverse true of Val/Val homozygotes, seemingly consistent with caregiving-controlling and punitive-controlling styles, respectively, but only in the case of maternal and not teacher reports, thereby confirmating a relationship-specific hypothesis.

No MeSH data available.


Sensitivity analyses: COMT X disorganization interaction pattern for Grade six mother-reported positive and negative child behavior. Note: This set of sensitivity analyses used ternary COMT coding (i.e., Val/Val, Met/Val and Met/Met) and continuous disorganization ratings (“0” = organized, “8” = most disorganized).
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Figure 5: Sensitivity analyses: COMT X disorganization interaction pattern for Grade six mother-reported positive and negative child behavior. Note: This set of sensitivity analyses used ternary COMT coding (i.e., Val/Val, Met/Val and Met/Met) and continuous disorganization ratings (“0” = organized, “8” = most disorganized).

Mentions: Inspection of Figure 3 indicates that disorganized Met carriers (Met/Met, Val/Met) scored higher than disorganized Val/Val homozygotes on mother-reported positive behavior, even if not to a significant extent (Cohen's d = 0.439, 95% CI: [-0.109, 0.988]), with the reverse being true for mother-reported negative composites (Met carriers < Val/Val, d = −0.526, 95% CI: [-1.076, 0.025]). These results show the same patterns of difference in grade 6 ratings as shown in kindergarten ratings in Figure 2. When COMT was coded in 3-levels (i.e., Met/Met, Met/Val and Val/Val), the best-fitting linear gene model constrained intercept and slope estimates for the Met/Val heterozygotes to fall exactly midway between corresponding estimates for the homozygous groups, with results shown for mother ratings of positive and negative composites in kindergarten and grade 6 in Figures 4, 5, respectively. This model suggests that the gene effect may be linear, rather than nonlinear as in the original results by Hygen et al. (2014). That is, Hygen et al. and our analyses in Tables 2, 3 implicitly had a recessive gene effect specified, presuming that the presence of two Val alleles would lead to different outcomes than for the Met/Met and Val/Met groups, the latter of which would have identical outcomes.


Disorganization, COMT, and Children's Social Behavior: The Norwegian Hypothesis of Legacy of Disorganized Attachment.

Li Z, Hygen BW, Widaman KF, Berg-Nielsen TS, Wichstrøm L, Belsky J - Front Psychol (2016)

Sensitivity analyses: COMT X disorganization interaction pattern for Grade six mother-reported positive and negative child behavior. Note: This set of sensitivity analyses used ternary COMT coding (i.e., Val/Val, Met/Val and Met/Met) and continuous disorganization ratings (“0” = organized, “8” = most disorganized).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4940399&req=5

Figure 5: Sensitivity analyses: COMT X disorganization interaction pattern for Grade six mother-reported positive and negative child behavior. Note: This set of sensitivity analyses used ternary COMT coding (i.e., Val/Val, Met/Val and Met/Met) and continuous disorganization ratings (“0” = organized, “8” = most disorganized).
Mentions: Inspection of Figure 3 indicates that disorganized Met carriers (Met/Met, Val/Met) scored higher than disorganized Val/Val homozygotes on mother-reported positive behavior, even if not to a significant extent (Cohen's d = 0.439, 95% CI: [-0.109, 0.988]), with the reverse being true for mother-reported negative composites (Met carriers < Val/Val, d = −0.526, 95% CI: [-1.076, 0.025]). These results show the same patterns of difference in grade 6 ratings as shown in kindergarten ratings in Figure 2. When COMT was coded in 3-levels (i.e., Met/Met, Met/Val and Val/Val), the best-fitting linear gene model constrained intercept and slope estimates for the Met/Val heterozygotes to fall exactly midway between corresponding estimates for the homozygous groups, with results shown for mother ratings of positive and negative composites in kindergarten and grade 6 in Figures 4, 5, respectively. This model suggests that the gene effect may be linear, rather than nonlinear as in the original results by Hygen et al. (2014). That is, Hygen et al. and our analyses in Tables 2, 3 implicitly had a recessive gene effect specified, presuming that the presence of two Val alleles would lead to different outcomes than for the Met/Met and Val/Met groups, the latter of which would have identical outcomes.

Bottom Line: Hygen et al. (2014) proposed that variation in the Catechol-O-methyl transferase(COMT) Val158Met genotype explains this variation, providing preliminary data to this effect.We offer a conceptual replication, analyzing data on 560 children (males: 275) drawn from the NICHD Study of Early Child Care and Youth Development.As predicted, competitive model-fitting indicated that disorganized infants carrying Met alleles engage in more positive behavior and less negative behavior than other children at age 5 and 11, with the reverse true of Val/Val homozygotes, seemingly consistent with caregiving-controlling and punitive-controlling styles, respectively, but only in the case of maternal and not teacher reports, thereby confirmating a relationship-specific hypothesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Ecology, University of California, Davis Davis, CA, USA.

ABSTRACT
Why is disorganized attachment associated with punitive-controlling behavior in some, but caregiving-controlling in others? Hygen et al. (2014) proposed that variation in the Catechol-O-methyl transferase(COMT) Val158Met genotype explains this variation, providing preliminary data to this effect. We offer a conceptual replication, analyzing data on 560 children (males: 275) drawn from the NICHD Study of Early Child Care and Youth Development. As predicted, competitive model-fitting indicated that disorganized infants carrying Met alleles engage in more positive behavior and less negative behavior than other children at age 5 and 11, with the reverse true of Val/Val homozygotes, seemingly consistent with caregiving-controlling and punitive-controlling styles, respectively, but only in the case of maternal and not teacher reports, thereby confirmating a relationship-specific hypothesis.

No MeSH data available.