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Disorganization, COMT, and Children's Social Behavior: The Norwegian Hypothesis of Legacy of Disorganized Attachment.

Li Z, Hygen BW, Widaman KF, Berg-Nielsen TS, Wichstrøm L, Belsky J - Front Psychol (2016)

Bottom Line: Hygen et al. (2014) proposed that variation in the Catechol-O-methyl transferase(COMT) Val158Met genotype explains this variation, providing preliminary data to this effect.We offer a conceptual replication, analyzing data on 560 children (males: 275) drawn from the NICHD Study of Early Child Care and Youth Development.As predicted, competitive model-fitting indicated that disorganized infants carrying Met alleles engage in more positive behavior and less negative behavior than other children at age 5 and 11, with the reverse true of Val/Val homozygotes, seemingly consistent with caregiving-controlling and punitive-controlling styles, respectively, but only in the case of maternal and not teacher reports, thereby confirmating a relationship-specific hypothesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Ecology, University of California, Davis Davis, CA, USA.

ABSTRACT
Why is disorganized attachment associated with punitive-controlling behavior in some, but caregiving-controlling in others? Hygen et al. (2014) proposed that variation in the Catechol-O-methyl transferase(COMT) Val158Met genotype explains this variation, providing preliminary data to this effect. We offer a conceptual replication, analyzing data on 560 children (males: 275) drawn from the NICHD Study of Early Child Care and Youth Development. As predicted, competitive model-fitting indicated that disorganized infants carrying Met alleles engage in more positive behavior and less negative behavior than other children at age 5 and 11, with the reverse true of Val/Val homozygotes, seemingly consistent with caregiving-controlling and punitive-controlling styles, respectively, but only in the case of maternal and not teacher reports, thereby confirmating a relationship-specific hypothesis.

No MeSH data available.


Sensitivity analyses: COMT X disorganization interaction pattern for Grade 6 mother-reported positive and negative child behavior (“0” = organized; “1” = disorganized). Note: This set of sensitivity analyses used binary COMT coding (i.e., Val/Val vs. Met carrier) and categorical disorganization score (“0” = organized; “1” = disorganized) to predict grade six child functioning.
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Figure 3: Sensitivity analyses: COMT X disorganization interaction pattern for Grade 6 mother-reported positive and negative child behavior (“0” = organized; “1” = disorganized). Note: This set of sensitivity analyses used binary COMT coding (i.e., Val/Val vs. Met carrier) and categorical disorganization score (“0” = organized; “1” = disorganized) to predict grade six child functioning.

Mentions: Results of these sensitivity analyses, which are presented in Table 3 (i.e., primary analysis re-run at Grade 6) and in Table 4 (i.e., primary analysis re-run using 3-level COMT and continuous D at both kindergarten and grade 6), proved generally in line with those reported already (see Figures 3–5). Before reporting these results in more detail, it should be noted that, as with the original analyses of mother-reported kindergarten outcomes, BIC values proved consistently smaller in the case of the hypothesized model, with the data once again being patterned in a manner in line with the Norwegian hypothesis. For example, in the grade 6 models reported in Table 3, the hypothesized model fit better than the full model in all cases, with ΔBIC values ranging from −4.94 (SD = 0.97) to −5.86 (SD = 0.16). For kindergarten and grade 6 analyses in Table 4, the linear model fit better than the full model in all cases, with ΔBIC values ranging from −10.74 (SD = 0.43) to −12.50 (SD = 0.08). Thus, BIC values always supported retention of our hypothesized, constrained models in comparison to more highly parameterized full models.


Disorganization, COMT, and Children's Social Behavior: The Norwegian Hypothesis of Legacy of Disorganized Attachment.

Li Z, Hygen BW, Widaman KF, Berg-Nielsen TS, Wichstrøm L, Belsky J - Front Psychol (2016)

Sensitivity analyses: COMT X disorganization interaction pattern for Grade 6 mother-reported positive and negative child behavior (“0” = organized; “1” = disorganized). Note: This set of sensitivity analyses used binary COMT coding (i.e., Val/Val vs. Met carrier) and categorical disorganization score (“0” = organized; “1” = disorganized) to predict grade six child functioning.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4940399&req=5

Figure 3: Sensitivity analyses: COMT X disorganization interaction pattern for Grade 6 mother-reported positive and negative child behavior (“0” = organized; “1” = disorganized). Note: This set of sensitivity analyses used binary COMT coding (i.e., Val/Val vs. Met carrier) and categorical disorganization score (“0” = organized; “1” = disorganized) to predict grade six child functioning.
Mentions: Results of these sensitivity analyses, which are presented in Table 3 (i.e., primary analysis re-run at Grade 6) and in Table 4 (i.e., primary analysis re-run using 3-level COMT and continuous D at both kindergarten and grade 6), proved generally in line with those reported already (see Figures 3–5). Before reporting these results in more detail, it should be noted that, as with the original analyses of mother-reported kindergarten outcomes, BIC values proved consistently smaller in the case of the hypothesized model, with the data once again being patterned in a manner in line with the Norwegian hypothesis. For example, in the grade 6 models reported in Table 3, the hypothesized model fit better than the full model in all cases, with ΔBIC values ranging from −4.94 (SD = 0.97) to −5.86 (SD = 0.16). For kindergarten and grade 6 analyses in Table 4, the linear model fit better than the full model in all cases, with ΔBIC values ranging from −10.74 (SD = 0.43) to −12.50 (SD = 0.08). Thus, BIC values always supported retention of our hypothesized, constrained models in comparison to more highly parameterized full models.

Bottom Line: Hygen et al. (2014) proposed that variation in the Catechol-O-methyl transferase(COMT) Val158Met genotype explains this variation, providing preliminary data to this effect.We offer a conceptual replication, analyzing data on 560 children (males: 275) drawn from the NICHD Study of Early Child Care and Youth Development.As predicted, competitive model-fitting indicated that disorganized infants carrying Met alleles engage in more positive behavior and less negative behavior than other children at age 5 and 11, with the reverse true of Val/Val homozygotes, seemingly consistent with caregiving-controlling and punitive-controlling styles, respectively, but only in the case of maternal and not teacher reports, thereby confirmating a relationship-specific hypothesis.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Ecology, University of California, Davis Davis, CA, USA.

ABSTRACT
Why is disorganized attachment associated with punitive-controlling behavior in some, but caregiving-controlling in others? Hygen et al. (2014) proposed that variation in the Catechol-O-methyl transferase(COMT) Val158Met genotype explains this variation, providing preliminary data to this effect. We offer a conceptual replication, analyzing data on 560 children (males: 275) drawn from the NICHD Study of Early Child Care and Youth Development. As predicted, competitive model-fitting indicated that disorganized infants carrying Met alleles engage in more positive behavior and less negative behavior than other children at age 5 and 11, with the reverse true of Val/Val homozygotes, seemingly consistent with caregiving-controlling and punitive-controlling styles, respectively, but only in the case of maternal and not teacher reports, thereby confirmating a relationship-specific hypothesis.

No MeSH data available.