Limits...
Transcranial Direct Current Stimulation (tDCS) of the Right Inferior Frontal Gyrus Attenuates Skin Conductance Responses to Unpredictable Threat Conditions.

Herrmann MJ, Beier JS, Simons B, Polak T - Front Hum Neurosci (2016)

Bottom Line: Interestingly, a recent study found that the right inferior frontal gyrus (rIFG) is correlated to the successful regulation of sustained fear during U threat.Therefore this study aimed to examine the potential use of non-invasive brain stimulation to foster the rIFG by means of anodal transcranial direct current stimulation (tDCS) in order to reduce psychophysiological reactions to U threat.Our results emphasize the causal role of rIFG for emotional regulation and the potential use of tDCS to reduce apprehension during U threat conditions and therefore as a treatment for anxiety disorders.

View Article: PubMed Central - PubMed

Affiliation: Laboratory for Psychophysiology and Functional Imaging, Department of Psychiatry, Psychosomatics and Psychotherapy, University Clinics of Würzburg Würzburg, Germany.

ABSTRACT
Patients with panic and post-traumatic stress disorders seem to show increased psychophysiological reactions to conditions of unpredictable (U) threat, which has been discussed as a neurobiological marker of elevated levels of sustained fear in these disorders. Interestingly, a recent study found that the right inferior frontal gyrus (rIFG) is correlated to the successful regulation of sustained fear during U threat. Therefore this study aimed to examine the potential use of non-invasive brain stimulation to foster the rIFG by means of anodal transcranial direct current stimulation (tDCS) in order to reduce psychophysiological reactions to U threat. Twenty six participants were randomly assigned into an anodal and sham stimulation group in a double-blinded manner. Anodal and cathodal electrodes (7 * 5 cm) were positioned right frontal to target the rIFG. Stimulation intensity was I = 2 mA applied for 20 min during a task including U threat conditions (NPU-task). The effects of the NPU paradigm were measured by assessing the emotional startle modulation and the skin conductance response (SCR) at the outset of the different conditions. We found a significant interaction effect of condition × tDCS for the SCR (F (2,48) = 6.3, p < 0.01) without main effects of condition and tDCS. Post hoc tests revealed that the increase in SCR from neutral (N) to U condition was significantly reduced in verum compared to the sham tDCS group (t (24) = 3.84, p < 0.001). Our results emphasize the causal role of rIFG for emotional regulation and the potential use of tDCS to reduce apprehension during U threat conditions and therefore as a treatment for anxiety disorders.

No MeSH data available.


Related in: MedlinePlus

Differential skin conductance response (SCR); (neutral (N)-[un]predictable) for both transcranial direct current stimulation (tDCS) groups. Displayed are mean values with standard errors of the mean of z-standardized values.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4940364&req=5

Figure 1: Differential skin conductance response (SCR); (neutral (N)-[un]predictable) for both transcranial direct current stimulation (tDCS) groups. Displayed are mean values with standard errors of the mean of z-standardized values.

Mentions: The post hoct-test revealed significant differences between sham and anodal group for the N and U conditions (see Table 2), leading to a significant lower increase from N to U condition in verum (M = −0.46 ± 0.23) compared to sham group (M = 0.80 ± 0.23; t(24) = 3.84; p < 0.001; see Figure 1). The changes from N to P condition do not differ significantly between verum (M = 0.04 ± 0.27) and sham group (M = 0.57 ± 0.21; t(24) = 1.52, p = 0.14).


Transcranial Direct Current Stimulation (tDCS) of the Right Inferior Frontal Gyrus Attenuates Skin Conductance Responses to Unpredictable Threat Conditions.

Herrmann MJ, Beier JS, Simons B, Polak T - Front Hum Neurosci (2016)

Differential skin conductance response (SCR); (neutral (N)-[un]predictable) for both transcranial direct current stimulation (tDCS) groups. Displayed are mean values with standard errors of the mean of z-standardized values.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4940364&req=5

Figure 1: Differential skin conductance response (SCR); (neutral (N)-[un]predictable) for both transcranial direct current stimulation (tDCS) groups. Displayed are mean values with standard errors of the mean of z-standardized values.
Mentions: The post hoct-test revealed significant differences between sham and anodal group for the N and U conditions (see Table 2), leading to a significant lower increase from N to U condition in verum (M = −0.46 ± 0.23) compared to sham group (M = 0.80 ± 0.23; t(24) = 3.84; p < 0.001; see Figure 1). The changes from N to P condition do not differ significantly between verum (M = 0.04 ± 0.27) and sham group (M = 0.57 ± 0.21; t(24) = 1.52, p = 0.14).

Bottom Line: Interestingly, a recent study found that the right inferior frontal gyrus (rIFG) is correlated to the successful regulation of sustained fear during U threat.Therefore this study aimed to examine the potential use of non-invasive brain stimulation to foster the rIFG by means of anodal transcranial direct current stimulation (tDCS) in order to reduce psychophysiological reactions to U threat.Our results emphasize the causal role of rIFG for emotional regulation and the potential use of tDCS to reduce apprehension during U threat conditions and therefore as a treatment for anxiety disorders.

View Article: PubMed Central - PubMed

Affiliation: Laboratory for Psychophysiology and Functional Imaging, Department of Psychiatry, Psychosomatics and Psychotherapy, University Clinics of Würzburg Würzburg, Germany.

ABSTRACT
Patients with panic and post-traumatic stress disorders seem to show increased psychophysiological reactions to conditions of unpredictable (U) threat, which has been discussed as a neurobiological marker of elevated levels of sustained fear in these disorders. Interestingly, a recent study found that the right inferior frontal gyrus (rIFG) is correlated to the successful regulation of sustained fear during U threat. Therefore this study aimed to examine the potential use of non-invasive brain stimulation to foster the rIFG by means of anodal transcranial direct current stimulation (tDCS) in order to reduce psychophysiological reactions to U threat. Twenty six participants were randomly assigned into an anodal and sham stimulation group in a double-blinded manner. Anodal and cathodal electrodes (7 * 5 cm) were positioned right frontal to target the rIFG. Stimulation intensity was I = 2 mA applied for 20 min during a task including U threat conditions (NPU-task). The effects of the NPU paradigm were measured by assessing the emotional startle modulation and the skin conductance response (SCR) at the outset of the different conditions. We found a significant interaction effect of condition × tDCS for the SCR (F (2,48) = 6.3, p < 0.01) without main effects of condition and tDCS. Post hoc tests revealed that the increase in SCR from neutral (N) to U condition was significantly reduced in verum compared to the sham tDCS group (t (24) = 3.84, p < 0.001). Our results emphasize the causal role of rIFG for emotional regulation and the potential use of tDCS to reduce apprehension during U threat conditions and therefore as a treatment for anxiety disorders.

No MeSH data available.


Related in: MedlinePlus