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The delta high-density lipoprotein cholesterol ratio: a novel parameter for gram-negative sepsis.

Zou G, He J, Ren B, Xu F, Xu G, Zhang W - Springerplus (2016)

Bottom Line: Particularly HDL-C was decreased 1 day after admission.Compared with the patients with gram-positive sepsis, HDL-C and apoA1 were significantly reduced in the patients with gram-negative sepsis at admission.The area under the curve was 0.744, and the critical value was -21.1 %.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Brain Hospital of Hunan Province, Furong Middle Road 427, Changsha, 410007 Hunan People's Republic of China ; Department of Medical Laboratory, Hunan University of Traditional Chinese Medicine, Changsha, People's Republic of China.

ABSTRACT

Objective: To study changes in blood lipid metabolism in sepsis patients, especially high-density lipoprotein cholesterol (HDL-C) changes in the diagnosis of sepsis and the type of bacteria involved.

Methods: Two-hundred-twenty cases of patients with febrile infections were divided into local infection, systemic inflammatory response syndrome or sepsis (sepsis) group. For controls, 81 cases of patients with a healthy check-up were used. Lipid levels and inflammatory state were supervised, and a comparative analysis of patients admitted to the hospital after 1, 5, 10 days was performed.

Results: In patients with sepsis, total cholesterol, HDL-C, and apolipoprotein A 1 (apoA 1) were significantly decreased in this group. Particularly HDL-C was decreased 1 day after admission. Compared with the patients with gram-positive sepsis, HDL-C and apoA1 were significantly reduced in the patients with gram-negative sepsis at admission. The 24-h change ratio of HDL-C was different between the gram-negative and gram-positive sepsis patients with a 70.5 % specificity and 76.5 % sensitivity. The area under the curve was 0.744, and the critical value was -21.1 %.

Conclusions: The sepsis patients had lower HDL-C than the other groups. The 24-h change ratio of HDL-C can be used as a sepsis diagnosis maker and to distinguish between the bacteria involved in sepsis.

No MeSH data available.


Related in: MedlinePlus

Receiver operating characteristic (ROC) curves comparing the serum HDL-C and apoA1 levels and the 24 h change ratio of HDL-C for distinguishing between gram+ sepsis (n = 33) and gram− sepsis (n = 43). The statistics of the ROC curve analysis and the significance of pairwise comparisons between the areas under the ROC curve (AUC) are also shown
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Fig3: Receiver operating characteristic (ROC) curves comparing the serum HDL-C and apoA1 levels and the 24 h change ratio of HDL-C for distinguishing between gram+ sepsis (n = 33) and gram− sepsis (n = 43). The statistics of the ROC curve analysis and the significance of pairwise comparisons between the areas under the ROC curve (AUC) are also shown

Mentions: The ROC curve analysis confirmed that the delta ratio of HDL-C was different between the gram− sepsis and gram+ sepsis patients and had a 70.5 % specificity and 76.5 % sensitivity. The area under the curve was 0.744 (SE = 0.057, p < 0.001). The highest observed value −21.1 % (Fig. 3; Table 4).Fig. 3


The delta high-density lipoprotein cholesterol ratio: a novel parameter for gram-negative sepsis.

Zou G, He J, Ren B, Xu F, Xu G, Zhang W - Springerplus (2016)

Receiver operating characteristic (ROC) curves comparing the serum HDL-C and apoA1 levels and the 24 h change ratio of HDL-C for distinguishing between gram+ sepsis (n = 33) and gram− sepsis (n = 43). The statistics of the ROC curve analysis and the significance of pairwise comparisons between the areas under the ROC curve (AUC) are also shown
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4940328&req=5

Fig3: Receiver operating characteristic (ROC) curves comparing the serum HDL-C and apoA1 levels and the 24 h change ratio of HDL-C for distinguishing between gram+ sepsis (n = 33) and gram− sepsis (n = 43). The statistics of the ROC curve analysis and the significance of pairwise comparisons between the areas under the ROC curve (AUC) are also shown
Mentions: The ROC curve analysis confirmed that the delta ratio of HDL-C was different between the gram− sepsis and gram+ sepsis patients and had a 70.5 % specificity and 76.5 % sensitivity. The area under the curve was 0.744 (SE = 0.057, p < 0.001). The highest observed value −21.1 % (Fig. 3; Table 4).Fig. 3

Bottom Line: Particularly HDL-C was decreased 1 day after admission.Compared with the patients with gram-positive sepsis, HDL-C and apoA1 were significantly reduced in the patients with gram-negative sepsis at admission.The area under the curve was 0.744, and the critical value was -21.1 %.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Brain Hospital of Hunan Province, Furong Middle Road 427, Changsha, 410007 Hunan People's Republic of China ; Department of Medical Laboratory, Hunan University of Traditional Chinese Medicine, Changsha, People's Republic of China.

ABSTRACT

Objective: To study changes in blood lipid metabolism in sepsis patients, especially high-density lipoprotein cholesterol (HDL-C) changes in the diagnosis of sepsis and the type of bacteria involved.

Methods: Two-hundred-twenty cases of patients with febrile infections were divided into local infection, systemic inflammatory response syndrome or sepsis (sepsis) group. For controls, 81 cases of patients with a healthy check-up were used. Lipid levels and inflammatory state were supervised, and a comparative analysis of patients admitted to the hospital after 1, 5, 10 days was performed.

Results: In patients with sepsis, total cholesterol, HDL-C, and apolipoprotein A 1 (apoA 1) were significantly decreased in this group. Particularly HDL-C was decreased 1 day after admission. Compared with the patients with gram-positive sepsis, HDL-C and apoA1 were significantly reduced in the patients with gram-negative sepsis at admission. The 24-h change ratio of HDL-C was different between the gram-negative and gram-positive sepsis patients with a 70.5 % specificity and 76.5 % sensitivity. The area under the curve was 0.744, and the critical value was -21.1 %.

Conclusions: The sepsis patients had lower HDL-C than the other groups. The 24-h change ratio of HDL-C can be used as a sepsis diagnosis maker and to distinguish between the bacteria involved in sepsis.

No MeSH data available.


Related in: MedlinePlus