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The delta high-density lipoprotein cholesterol ratio: a novel parameter for gram-negative sepsis.

Zou G, He J, Ren B, Xu F, Xu G, Zhang W - Springerplus (2016)

Bottom Line: Particularly HDL-C was decreased 1 day after admission.Compared with the patients with gram-positive sepsis, HDL-C and apoA1 were significantly reduced in the patients with gram-negative sepsis at admission.The area under the curve was 0.744, and the critical value was -21.1 %.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Brain Hospital of Hunan Province, Furong Middle Road 427, Changsha, 410007 Hunan People's Republic of China ; Department of Medical Laboratory, Hunan University of Traditional Chinese Medicine, Changsha, People's Republic of China.

ABSTRACT

Objective: To study changes in blood lipid metabolism in sepsis patients, especially high-density lipoprotein cholesterol (HDL-C) changes in the diagnosis of sepsis and the type of bacteria involved.

Methods: Two-hundred-twenty cases of patients with febrile infections were divided into local infection, systemic inflammatory response syndrome or sepsis (sepsis) group. For controls, 81 cases of patients with a healthy check-up were used. Lipid levels and inflammatory state were supervised, and a comparative analysis of patients admitted to the hospital after 1, 5, 10 days was performed.

Results: In patients with sepsis, total cholesterol, HDL-C, and apolipoprotein A 1 (apoA 1) were significantly decreased in this group. Particularly HDL-C was decreased 1 day after admission. Compared with the patients with gram-positive sepsis, HDL-C and apoA1 were significantly reduced in the patients with gram-negative sepsis at admission. The 24-h change ratio of HDL-C was different between the gram-negative and gram-positive sepsis patients with a 70.5 % specificity and 76.5 % sensitivity. The area under the curve was 0.744, and the critical value was -21.1 %.

Conclusions: The sepsis patients had lower HDL-C than the other groups. The 24-h change ratio of HDL-C can be used as a sepsis diagnosis maker and to distinguish between the bacteria involved in sepsis.

No MeSH data available.


Related in: MedlinePlus

Influence of different Gram stain bacterial sepsis on the blood lipid levels at admission. a High-density lipoprotein cholesterol. b Apolipoprotein A1. The box chart statistics (mean value and SEM). The difference between the Gram+ and Gram− sepsis groups were tested using an independent-samples T test
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Fig2: Influence of different Gram stain bacterial sepsis on the blood lipid levels at admission. a High-density lipoprotein cholesterol. b Apolipoprotein A1. The box chart statistics (mean value and SEM). The difference between the Gram+ and Gram− sepsis groups were tested using an independent-samples T test

Mentions: In this study, we observed that HDL-C was more greatly inhibited in gram− sepsis. Although PCT can indicate patients’ inflammatory state, can’t distinguish different gram-stained type. From the analysis of the lipids levels of the sepsis patients with different gram-stained bacteria at admission, we found that compared with the patients with gram+ sepsis, HDL-C (p < 0.001) and apoA1 (p = 0.008) were significantly reduced in the patients with gram− sepsis (Fig. 2; Table 3). The remaining blood lipid parameters were not different between the Gram classifications (Table 3).Fig. 2


The delta high-density lipoprotein cholesterol ratio: a novel parameter for gram-negative sepsis.

Zou G, He J, Ren B, Xu F, Xu G, Zhang W - Springerplus (2016)

Influence of different Gram stain bacterial sepsis on the blood lipid levels at admission. a High-density lipoprotein cholesterol. b Apolipoprotein A1. The box chart statistics (mean value and SEM). The difference between the Gram+ and Gram− sepsis groups were tested using an independent-samples T test
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4940328&req=5

Fig2: Influence of different Gram stain bacterial sepsis on the blood lipid levels at admission. a High-density lipoprotein cholesterol. b Apolipoprotein A1. The box chart statistics (mean value and SEM). The difference between the Gram+ and Gram− sepsis groups were tested using an independent-samples T test
Mentions: In this study, we observed that HDL-C was more greatly inhibited in gram− sepsis. Although PCT can indicate patients’ inflammatory state, can’t distinguish different gram-stained type. From the analysis of the lipids levels of the sepsis patients with different gram-stained bacteria at admission, we found that compared with the patients with gram+ sepsis, HDL-C (p < 0.001) and apoA1 (p = 0.008) were significantly reduced in the patients with gram− sepsis (Fig. 2; Table 3). The remaining blood lipid parameters were not different between the Gram classifications (Table 3).Fig. 2

Bottom Line: Particularly HDL-C was decreased 1 day after admission.Compared with the patients with gram-positive sepsis, HDL-C and apoA1 were significantly reduced in the patients with gram-negative sepsis at admission.The area under the curve was 0.744, and the critical value was -21.1 %.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Brain Hospital of Hunan Province, Furong Middle Road 427, Changsha, 410007 Hunan People's Republic of China ; Department of Medical Laboratory, Hunan University of Traditional Chinese Medicine, Changsha, People's Republic of China.

ABSTRACT

Objective: To study changes in blood lipid metabolism in sepsis patients, especially high-density lipoprotein cholesterol (HDL-C) changes in the diagnosis of sepsis and the type of bacteria involved.

Methods: Two-hundred-twenty cases of patients with febrile infections were divided into local infection, systemic inflammatory response syndrome or sepsis (sepsis) group. For controls, 81 cases of patients with a healthy check-up were used. Lipid levels and inflammatory state were supervised, and a comparative analysis of patients admitted to the hospital after 1, 5, 10 days was performed.

Results: In patients with sepsis, total cholesterol, HDL-C, and apolipoprotein A 1 (apoA 1) were significantly decreased in this group. Particularly HDL-C was decreased 1 day after admission. Compared with the patients with gram-positive sepsis, HDL-C and apoA1 were significantly reduced in the patients with gram-negative sepsis at admission. The 24-h change ratio of HDL-C was different between the gram-negative and gram-positive sepsis patients with a 70.5 % specificity and 76.5 % sensitivity. The area under the curve was 0.744, and the critical value was -21.1 %.

Conclusions: The sepsis patients had lower HDL-C than the other groups. The 24-h change ratio of HDL-C can be used as a sepsis diagnosis maker and to distinguish between the bacteria involved in sepsis.

No MeSH data available.


Related in: MedlinePlus