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The delta high-density lipoprotein cholesterol ratio: a novel parameter for gram-negative sepsis.

Zou G, He J, Ren B, Xu F, Xu G, Zhang W - Springerplus (2016)

Bottom Line: Particularly HDL-C was decreased 1 day after admission.Compared with the patients with gram-positive sepsis, HDL-C and apoA1 were significantly reduced in the patients with gram-negative sepsis at admission.The area under the curve was 0.744, and the critical value was -21.1 %.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Brain Hospital of Hunan Province, Furong Middle Road 427, Changsha, 410007 Hunan People's Republic of China ; Department of Medical Laboratory, Hunan University of Traditional Chinese Medicine, Changsha, People's Republic of China.

ABSTRACT

Objective: To study changes in blood lipid metabolism in sepsis patients, especially high-density lipoprotein cholesterol (HDL-C) changes in the diagnosis of sepsis and the type of bacteria involved.

Methods: Two-hundred-twenty cases of patients with febrile infections were divided into local infection, systemic inflammatory response syndrome or sepsis (sepsis) group. For controls, 81 cases of patients with a healthy check-up were used. Lipid levels and inflammatory state were supervised, and a comparative analysis of patients admitted to the hospital after 1, 5, 10 days was performed.

Results: In patients with sepsis, total cholesterol, HDL-C, and apolipoprotein A 1 (apoA 1) were significantly decreased in this group. Particularly HDL-C was decreased 1 day after admission. Compared with the patients with gram-positive sepsis, HDL-C and apoA1 were significantly reduced in the patients with gram-negative sepsis at admission. The 24-h change ratio of HDL-C was different between the gram-negative and gram-positive sepsis patients with a 70.5 % specificity and 76.5 % sensitivity. The area under the curve was 0.744, and the critical value was -21.1 %.

Conclusions: The sepsis patients had lower HDL-C than the other groups. The 24-h change ratio of HDL-C can be used as a sepsis diagnosis maker and to distinguish between the bacteria involved in sepsis.

No MeSH data available.


Related in: MedlinePlus

Serum lipid levels and inflammatory state at different times after admission. a Total cholesterol; b high-density lipoprotein cholesterol; c triglycerides; d apolipoprotein A1; e apolipoprotein B; f C-reactive protein; g procalcitonin. The box chart statistics (mean value and SD) of the data are also shown. Two-way factorial analysis of variance with repeated measures was used to quantify the main effects during the 10-day hospital admission. The post hoc analysis was performed using a Bonferroni correction for multiple comparisons
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Fig1: Serum lipid levels and inflammatory state at different times after admission. a Total cholesterol; b high-density lipoprotein cholesterol; c triglycerides; d apolipoprotein A1; e apolipoprotein B; f C-reactive protein; g procalcitonin. The box chart statistics (mean value and SD) of the data are also shown. Two-way factorial analysis of variance with repeated measures was used to quantify the main effects during the 10-day hospital admission. The post hoc analysis was performed using a Bonferroni correction for multiple comparisons

Mentions: Because the blood lipid parameters changed at admission in the febrile infectious subjects, we next determined whether the blood lipid parameters had dynamic changes during hospitalization in our study subjects. By monitoring the levels of serum blood lipids at 0, 1, 5, 10 days after admission, we found that the febrile infectious subjects had differences in blood lipid levels, sch as TCH (p = 0.003), HDL-C (p < 0.001) and apoB (p < 0.001), and in inflammatory parameter PCT (p < 0.001). These levels also significantly changed during the course of the admission in different patients. The HDL-C levels had a tendency to only be reduced in the sepsis group and generally began to drop within 24 h of admission. The SIRS subjects had elevated TCH and apoB. PCT started to elevate within 5 days after admission in all febrile infectious patients (p < 0.001) (Fig. 1). These results illustrate that HDL-C was markedly suppressed in the sepsis patients during hospitalization.Fig. 1


The delta high-density lipoprotein cholesterol ratio: a novel parameter for gram-negative sepsis.

Zou G, He J, Ren B, Xu F, Xu G, Zhang W - Springerplus (2016)

Serum lipid levels and inflammatory state at different times after admission. a Total cholesterol; b high-density lipoprotein cholesterol; c triglycerides; d apolipoprotein A1; e apolipoprotein B; f C-reactive protein; g procalcitonin. The box chart statistics (mean value and SD) of the data are also shown. Two-way factorial analysis of variance with repeated measures was used to quantify the main effects during the 10-day hospital admission. The post hoc analysis was performed using a Bonferroni correction for multiple comparisons
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4940328&req=5

Fig1: Serum lipid levels and inflammatory state at different times after admission. a Total cholesterol; b high-density lipoprotein cholesterol; c triglycerides; d apolipoprotein A1; e apolipoprotein B; f C-reactive protein; g procalcitonin. The box chart statistics (mean value and SD) of the data are also shown. Two-way factorial analysis of variance with repeated measures was used to quantify the main effects during the 10-day hospital admission. The post hoc analysis was performed using a Bonferroni correction for multiple comparisons
Mentions: Because the blood lipid parameters changed at admission in the febrile infectious subjects, we next determined whether the blood lipid parameters had dynamic changes during hospitalization in our study subjects. By monitoring the levels of serum blood lipids at 0, 1, 5, 10 days after admission, we found that the febrile infectious subjects had differences in blood lipid levels, sch as TCH (p = 0.003), HDL-C (p < 0.001) and apoB (p < 0.001), and in inflammatory parameter PCT (p < 0.001). These levels also significantly changed during the course of the admission in different patients. The HDL-C levels had a tendency to only be reduced in the sepsis group and generally began to drop within 24 h of admission. The SIRS subjects had elevated TCH and apoB. PCT started to elevate within 5 days after admission in all febrile infectious patients (p < 0.001) (Fig. 1). These results illustrate that HDL-C was markedly suppressed in the sepsis patients during hospitalization.Fig. 1

Bottom Line: Particularly HDL-C was decreased 1 day after admission.Compared with the patients with gram-positive sepsis, HDL-C and apoA1 were significantly reduced in the patients with gram-negative sepsis at admission.The area under the curve was 0.744, and the critical value was -21.1 %.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Brain Hospital of Hunan Province, Furong Middle Road 427, Changsha, 410007 Hunan People's Republic of China ; Department of Medical Laboratory, Hunan University of Traditional Chinese Medicine, Changsha, People's Republic of China.

ABSTRACT

Objective: To study changes in blood lipid metabolism in sepsis patients, especially high-density lipoprotein cholesterol (HDL-C) changes in the diagnosis of sepsis and the type of bacteria involved.

Methods: Two-hundred-twenty cases of patients with febrile infections were divided into local infection, systemic inflammatory response syndrome or sepsis (sepsis) group. For controls, 81 cases of patients with a healthy check-up were used. Lipid levels and inflammatory state were supervised, and a comparative analysis of patients admitted to the hospital after 1, 5, 10 days was performed.

Results: In patients with sepsis, total cholesterol, HDL-C, and apolipoprotein A 1 (apoA 1) were significantly decreased in this group. Particularly HDL-C was decreased 1 day after admission. Compared with the patients with gram-positive sepsis, HDL-C and apoA1 were significantly reduced in the patients with gram-negative sepsis at admission. The 24-h change ratio of HDL-C was different between the gram-negative and gram-positive sepsis patients with a 70.5 % specificity and 76.5 % sensitivity. The area under the curve was 0.744, and the critical value was -21.1 %.

Conclusions: The sepsis patients had lower HDL-C than the other groups. The 24-h change ratio of HDL-C can be used as a sepsis diagnosis maker and to distinguish between the bacteria involved in sepsis.

No MeSH data available.


Related in: MedlinePlus