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Two New Highly Oxygenated Spirostanol Saponins from Paris polyphylla var. stenophylla.

Jin LY, Lu TX, Qin XJ, Ni W, Yan H, Chen Y, Liu H, He HP, Liu HY - Nat Prod Bioprospect (2016)

Bottom Line: Phytochemical investigation of the rhizomes of Paris polyphylla var. stenophylla led to the isolation of two new highly oxygenated spirostanol saponins, named paristenosides A (1) and B (2), together with seven known compounds.In addition, the cytotoxicity of the two new saponins was tested.Two new highly oxygenated spirostanol saponins, paristenosides A (1) and B (2), were isolated from the rhizomes of Paris polyphylla var. stenophylla.

View Article: PubMed Central - PubMed

Affiliation: College of Pharmacy and Chemistry, Dali University, Dali, 671000, China.

ABSTRACT
Phytochemical investigation of the rhizomes of Paris polyphylla var. stenophylla led to the isolation of two new highly oxygenated spirostanol saponins, named paristenosides A (1) and B (2), together with seven known compounds. Their structures were established mainly on the base of NMR spectroscopic techniques and mass spectrometry, as well as chemical methods. In addition, the cytotoxicity of the two new saponins was tested. Two new highly oxygenated spirostanol saponins, paristenosides A (1) and B (2), were isolated from the rhizomes of Paris polyphylla var. stenophylla. Their structures were established mainly based on NMR spectroscopic techniques and mass spectrometry, as well as chemical methods.

No MeSH data available.


Chemical structures of paristenosides A (1) and B (2)
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Fig1: Chemical structures of paristenosides A (1) and B (2)

Mentions: P. polyphylla var. stenophylla Franch. is one of the variations of P. polyphylla and has been used as a herbal medicine to treat skin furuncle and skin tinea, stop bleeding, and move clean blood and bad blood out by the Yi nationality of Liangshan in Sichuan Province [12]. Due to having certain resources, its rhizomes have been as the main steam commodities of Rhizoma Paridis. However, there are a few reports about the research of its material basis [13]. In order to clarify its chemical quality, we performed a phytochemical investigation of the rhizomes of P. polyphylla var. stenophylla. As a result, two new polyhydroxylated steroidal saponis, named paristenosides A (1) and B (2), were isolated from the title species. Meanwhile, seven known compounds were obtained and identified as paris saponin H (3) [14], Tg (4) [15], Pb (5) [16], Th (6) [17], Methyl-Th (7) [18], parispseudoside A (8) [19] and β-ecdysone (9) [16]. In the current paper, we report the isolation, structural elucidation, and cytotoxicity of the two new compounds (Fig. 1).Fig. 1


Two New Highly Oxygenated Spirostanol Saponins from Paris polyphylla var. stenophylla.

Jin LY, Lu TX, Qin XJ, Ni W, Yan H, Chen Y, Liu H, He HP, Liu HY - Nat Prod Bioprospect (2016)

Chemical structures of paristenosides A (1) and B (2)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4940253&req=5

Fig1: Chemical structures of paristenosides A (1) and B (2)
Mentions: P. polyphylla var. stenophylla Franch. is one of the variations of P. polyphylla and has been used as a herbal medicine to treat skin furuncle and skin tinea, stop bleeding, and move clean blood and bad blood out by the Yi nationality of Liangshan in Sichuan Province [12]. Due to having certain resources, its rhizomes have been as the main steam commodities of Rhizoma Paridis. However, there are a few reports about the research of its material basis [13]. In order to clarify its chemical quality, we performed a phytochemical investigation of the rhizomes of P. polyphylla var. stenophylla. As a result, two new polyhydroxylated steroidal saponis, named paristenosides A (1) and B (2), were isolated from the title species. Meanwhile, seven known compounds were obtained and identified as paris saponin H (3) [14], Tg (4) [15], Pb (5) [16], Th (6) [17], Methyl-Th (7) [18], parispseudoside A (8) [19] and β-ecdysone (9) [16]. In the current paper, we report the isolation, structural elucidation, and cytotoxicity of the two new compounds (Fig. 1).Fig. 1

Bottom Line: Phytochemical investigation of the rhizomes of Paris polyphylla var. stenophylla led to the isolation of two new highly oxygenated spirostanol saponins, named paristenosides A (1) and B (2), together with seven known compounds.In addition, the cytotoxicity of the two new saponins was tested.Two new highly oxygenated spirostanol saponins, paristenosides A (1) and B (2), were isolated from the rhizomes of Paris polyphylla var. stenophylla.

View Article: PubMed Central - PubMed

Affiliation: College of Pharmacy and Chemistry, Dali University, Dali, 671000, China.

ABSTRACT
Phytochemical investigation of the rhizomes of Paris polyphylla var. stenophylla led to the isolation of two new highly oxygenated spirostanol saponins, named paristenosides A (1) and B (2), together with seven known compounds. Their structures were established mainly on the base of NMR spectroscopic techniques and mass spectrometry, as well as chemical methods. In addition, the cytotoxicity of the two new saponins was tested. Two new highly oxygenated spirostanol saponins, paristenosides A (1) and B (2), were isolated from the rhizomes of Paris polyphylla var. stenophylla. Their structures were established mainly based on NMR spectroscopic techniques and mass spectrometry, as well as chemical methods.

No MeSH data available.