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Histopathological Characterization of Tail Injury and Traumatic Neuroma Development after Tail Docking in Piglets.

Sandercock DA, Smith SH, Di Giminiani P, Edwards SA - J. Comp. Pathol. (2016)

Bottom Line: Tissues were processed routinely for histopathological examination.Non-neural inflammatory and reparative epidermal and dermal changes associated with tissue thickening and healing were observed 1 to 4 months after docking.Mild neutrophilic inflammation was present in some cases, although this and other degenerative and non-neural reparative changes are not likely to have caused pain.

View Article: PubMed Central - PubMed

Affiliation: Animal and Veterinary Science Research Group, Scotland's Rural College (SRUC), West Mains Road, Edinburgh, UK. Electronic address: dale.sandercock@sruc.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Photomicrographs of histopathological features in sections of pig tail stump 8 weeks after docking. (A) Fully healed superficially with no external signs of tissue trauma associated with amputation. A granulation tissue ‘cap’ is evident in the dermis. HE. (B) Granulation tissue cap (*) covering docked end of coccygeal bone (arrowhead), with peripheral nerve (**) curving around the docked end (S100 expression). IHC. (C) Transition between transected nerve and granulation tissue. HE. (D) Neuroma and multiple axonal sprouts within the granulation tissue (S100 expression). IHC.
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fig4: Photomicrographs of histopathological features in sections of pig tail stump 8 weeks after docking. (A) Fully healed superficially with no external signs of tissue trauma associated with amputation. A granulation tissue ‘cap’ is evident in the dermis. HE. (B) Granulation tissue cap (*) covering docked end of coccygeal bone (arrowhead), with peripheral nerve (**) curving around the docked end (S100 expression). IHC. (C) Transition between transected nerve and granulation tissue. HE. (D) Neuroma and multiple axonal sprouts within the granulation tissue (S100 expression). IHC.

Mentions: On gross examination at 8 weeks of age, the docked tails were fully healed with no obvious external signs of tissue trauma associated with amputation. Many histopathological features were similar to those seen 4 weeks after tail docking. All tails were fully re-epithelialized, with some signs of mild epidermal hyperplasia, orthokeratotic hyperkeratosis and parakeratosis. Mild intra-epidermal and subcorneal pustules were observed in one of the tails. Mild, superficial and deep, perivascular dermatitis was present in some tails (mainly consisting of lymphocytes and plasma cells). In the dermis a well-defined granulation tissue cap was still evident, comprising dermal fibroplasia and angiogenesis, with capping of the cut vertebral end (Fig. 4A, B). Mild, dermal, neutrophilic inflammation was evident in two of four tails, but dermal oedema was not present. Some evidence of bone remodelling was present in one tail, but coccygeal myofibre atrophy or regeneration was not observed. Neuromas/neuromatous tissues were observed in all tails by S100 immunolabelling at this stage post injury (in both dorsal and ventral nerves), with less apparent axonal and nerve sheath proliferation (Fig. 4C, D).


Histopathological Characterization of Tail Injury and Traumatic Neuroma Development after Tail Docking in Piglets.

Sandercock DA, Smith SH, Di Giminiani P, Edwards SA - J. Comp. Pathol. (2016)

Photomicrographs of histopathological features in sections of pig tail stump 8 weeks after docking. (A) Fully healed superficially with no external signs of tissue trauma associated with amputation. A granulation tissue ‘cap’ is evident in the dermis. HE. (B) Granulation tissue cap (*) covering docked end of coccygeal bone (arrowhead), with peripheral nerve (**) curving around the docked end (S100 expression). IHC. (C) Transition between transected nerve and granulation tissue. HE. (D) Neuroma and multiple axonal sprouts within the granulation tissue (S100 expression). IHC.
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4940206&req=5

fig4: Photomicrographs of histopathological features in sections of pig tail stump 8 weeks after docking. (A) Fully healed superficially with no external signs of tissue trauma associated with amputation. A granulation tissue ‘cap’ is evident in the dermis. HE. (B) Granulation tissue cap (*) covering docked end of coccygeal bone (arrowhead), with peripheral nerve (**) curving around the docked end (S100 expression). IHC. (C) Transition between transected nerve and granulation tissue. HE. (D) Neuroma and multiple axonal sprouts within the granulation tissue (S100 expression). IHC.
Mentions: On gross examination at 8 weeks of age, the docked tails were fully healed with no obvious external signs of tissue trauma associated with amputation. Many histopathological features were similar to those seen 4 weeks after tail docking. All tails were fully re-epithelialized, with some signs of mild epidermal hyperplasia, orthokeratotic hyperkeratosis and parakeratosis. Mild intra-epidermal and subcorneal pustules were observed in one of the tails. Mild, superficial and deep, perivascular dermatitis was present in some tails (mainly consisting of lymphocytes and plasma cells). In the dermis a well-defined granulation tissue cap was still evident, comprising dermal fibroplasia and angiogenesis, with capping of the cut vertebral end (Fig. 4A, B). Mild, dermal, neutrophilic inflammation was evident in two of four tails, but dermal oedema was not present. Some evidence of bone remodelling was present in one tail, but coccygeal myofibre atrophy or regeneration was not observed. Neuromas/neuromatous tissues were observed in all tails by S100 immunolabelling at this stage post injury (in both dorsal and ventral nerves), with less apparent axonal and nerve sheath proliferation (Fig. 4C, D).

Bottom Line: Tissues were processed routinely for histopathological examination.Non-neural inflammatory and reparative epidermal and dermal changes associated with tissue thickening and healing were observed 1 to 4 months after docking.Mild neutrophilic inflammation was present in some cases, although this and other degenerative and non-neural reparative changes are not likely to have caused pain.

View Article: PubMed Central - PubMed

Affiliation: Animal and Veterinary Science Research Group, Scotland's Rural College (SRUC), West Mains Road, Edinburgh, UK. Electronic address: dale.sandercock@sruc.ac.uk.

No MeSH data available.


Related in: MedlinePlus