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Muscular invasion by oral squamous cell carcinoma of the posterior mandibular alveolar ridge is associated with cervical lymph node metastasis.

Min SK, Myoung H, Lee JH, Kim MJ - J Korean Assoc Oral Maxillofac Surg (2016)

Bottom Line: Cervical lymph node metastasis and masticator space invasion had a negative effect on overall survival.No lymphatic vessels were identified near the tumor invasion front within the mandible.In contrast, lymphatic vessels were identified near the front of tumor invasion in the muscles.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul, Korea.

ABSTRACT

Objectives: To assess the association between muscle invasion by oral squamous cell carcinoma of the posterior mandibular alveolar ridge and cervical lymph node metastasis on the basis of preoperative magnetic resonance imaging (MRI).

Materials and methods: Twenty-six patients with oral squamous cell carcinoma of the posterior mandibular alveolar ridge were evaluated by MRI. The associations between cervical lymph node metastasis and independent factors evaluated by MRI were analyzed. Overall survival was also analyzed in this manner. Representative biopsy specimens were stained with anti-podoplanin and anti-CD34 antibodies.

Results: Mylohyoid muscle invasion was associated with cervical lymph node metastasis. A combinational factor of mylohyoid and/or buccinator muscle invasion was also associated with cervical lymph node metastasis. Cervical lymph node metastasis and masticator space invasion had a negative effect on overall survival. No lymphatic vessels were identified near the tumor invasion front within the mandible. In contrast, lymphatic vessels were identified near the front of tumor invasion in the muscles.

Conclusion: This study demonstrates an association between muscular invasion by oral squamous cell carcinoma of the posterior mandibular alveolar ridge and cervical lymph node metastasis.

No MeSH data available.


Related in: MedlinePlus

Anatomical factors assessed on preoperative magnetic resonance imaging. Examples of bone marrow invasion (arrow) (A), sublingual space invasion (arrowhead) and buccinator muscle invasion (arrow) (B), masticator space invasion (arrow) (C), and mylohyoid muscle invasion (arrow) (D) are shown.
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Figure 1: Anatomical factors assessed on preoperative magnetic resonance imaging. Examples of bone marrow invasion (arrow) (A), sublingual space invasion (arrowhead) and buccinator muscle invasion (arrow) (B), masticator space invasion (arrow) (C), and mylohyoid muscle invasion (arrow) (D) are shown.

Mentions: All patients underwent preoperative MRI before surgery. As we speculated that anatomical factors of the primary tumor would influence cervical lymph node metastasis, we assessed factors such as greatest tumor dimension, bone marrow invasion, sublingual space invasion, masticator space invasion, buccinator muscle invasion, and mylohyoid muscle invasion. Invasion of the bone marrow was assessed by determining the presence of tumor signals in the marrow space, in continuum to the primary tumor.(Fig. 1. A) Invasions of the sublingual space and masticator space were evaluated similarly.(Fig. 1. B, 1. C) Both buccinator muscle invasion and mylohyoid muscle invasion were determined by the integrity of the representative muscles and the presence of adjacent tumor.(Fig. 1. B, 1. D) An additional factor of muscle invasion was determined by presence of tumor invasion in at least one of the aforementioned muscles. The correlation of the factors assessed on MRI, as well as age and sex, with cervical lymph node metastasis was assessed by Fisher's exact test with a significance level of 0.05. SPSS Statistics 17.0 (SPSS Inc., Chicago, IL, USA) was used for statistical analysis.


Muscular invasion by oral squamous cell carcinoma of the posterior mandibular alveolar ridge is associated with cervical lymph node metastasis.

Min SK, Myoung H, Lee JH, Kim MJ - J Korean Assoc Oral Maxillofac Surg (2016)

Anatomical factors assessed on preoperative magnetic resonance imaging. Examples of bone marrow invasion (arrow) (A), sublingual space invasion (arrowhead) and buccinator muscle invasion (arrow) (B), masticator space invasion (arrow) (C), and mylohyoid muscle invasion (arrow) (D) are shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4940197&req=5

Figure 1: Anatomical factors assessed on preoperative magnetic resonance imaging. Examples of bone marrow invasion (arrow) (A), sublingual space invasion (arrowhead) and buccinator muscle invasion (arrow) (B), masticator space invasion (arrow) (C), and mylohyoid muscle invasion (arrow) (D) are shown.
Mentions: All patients underwent preoperative MRI before surgery. As we speculated that anatomical factors of the primary tumor would influence cervical lymph node metastasis, we assessed factors such as greatest tumor dimension, bone marrow invasion, sublingual space invasion, masticator space invasion, buccinator muscle invasion, and mylohyoid muscle invasion. Invasion of the bone marrow was assessed by determining the presence of tumor signals in the marrow space, in continuum to the primary tumor.(Fig. 1. A) Invasions of the sublingual space and masticator space were evaluated similarly.(Fig. 1. B, 1. C) Both buccinator muscle invasion and mylohyoid muscle invasion were determined by the integrity of the representative muscles and the presence of adjacent tumor.(Fig. 1. B, 1. D) An additional factor of muscle invasion was determined by presence of tumor invasion in at least one of the aforementioned muscles. The correlation of the factors assessed on MRI, as well as age and sex, with cervical lymph node metastasis was assessed by Fisher's exact test with a significance level of 0.05. SPSS Statistics 17.0 (SPSS Inc., Chicago, IL, USA) was used for statistical analysis.

Bottom Line: Cervical lymph node metastasis and masticator space invasion had a negative effect on overall survival.No lymphatic vessels were identified near the tumor invasion front within the mandible.In contrast, lymphatic vessels were identified near the front of tumor invasion in the muscles.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul, Korea.

ABSTRACT

Objectives: To assess the association between muscle invasion by oral squamous cell carcinoma of the posterior mandibular alveolar ridge and cervical lymph node metastasis on the basis of preoperative magnetic resonance imaging (MRI).

Materials and methods: Twenty-six patients with oral squamous cell carcinoma of the posterior mandibular alveolar ridge were evaluated by MRI. The associations between cervical lymph node metastasis and independent factors evaluated by MRI were analyzed. Overall survival was also analyzed in this manner. Representative biopsy specimens were stained with anti-podoplanin and anti-CD34 antibodies.

Results: Mylohyoid muscle invasion was associated with cervical lymph node metastasis. A combinational factor of mylohyoid and/or buccinator muscle invasion was also associated with cervical lymph node metastasis. Cervical lymph node metastasis and masticator space invasion had a negative effect on overall survival. No lymphatic vessels were identified near the tumor invasion front within the mandible. In contrast, lymphatic vessels were identified near the front of tumor invasion in the muscles.

Conclusion: This study demonstrates an association between muscular invasion by oral squamous cell carcinoma of the posterior mandibular alveolar ridge and cervical lymph node metastasis.

No MeSH data available.


Related in: MedlinePlus