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Early Markers of Atherosclerotic Disease in Individuals with ExcessWeight and Dyslipidemia

View Article: PubMed Central - PubMed

ABSTRACT

Background: Excessive weight is a cardiovascular risk factor since it generates a chronicinflammatory process that aggravates the endothelial function.

Objective: To evaluate the endothelial function in individuals with excess weight andmild dyslipidemia using brachial artery flow-mediated dilation (BAFMD), andthe association of endothelial function with anthropometric and biochemicalvariables.

Methods: Cross-sectional study that included 74 individuals and evaluatedanthropometric variables (body mass index [BMI], waist-hip ratio [WHR],waist circumference [AC], and percentage of body fat [PBF]), biochemical(blood glucose, insulinemia, ultrasensitive C-reactive protein, fibrinogen,total cholesterol, HDL-cholesterol, triglycerides, and LDL-cholesterol) andendothelial function (BAFMD, evaluated by ultrasound). The statisticalanalysis was performed with SPSS, version 16.0. To study the associationbetween the variables, we used chi-square, Student's t and Mann-Whitneytests, and Pearson's correlation. Logistic regression analyzed theindependent influence of the factors. Values of p < 0.05 were consideredsignificant.

Results: The participants had a mean age of 50.8 years, and 57% were female. BMI, WC,WHR, and PBF showed no significant association with BAFMD. The male gender(p = 0.02) and higher serum levels of fibrinogen (p = 0.02) weresignificantly and independently associated with a BAFMD below 8%.

Conclusions: In individuals with excess weight and mild untreated dyslipidemia, malegender and higher levels of fibrinogen were independently associated withworse BAFMD.

No MeSH data available.


Related in: MedlinePlus

Association between fibrinogen levels and brachial artery flow-mediateddilatation. BAFMD: Brachial artery flow-mediated dilatation
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f2: Association between fibrinogen levels and brachial artery flow-mediateddilatation. BAFMD: Brachial artery flow-mediated dilatation

Mentions: The biochemical results of the metabolic parameters and inflammatory markers weretreated as quantitative variables and their associations with the endothelialfunction were verified with Student's t test (Table 2). Fibrinogen was the only biochemicalparameter significantly associated with the endothelial function (p = 0.02) (Figure 2). When this association was evaluated byquartiles of dilation, we observed that for dilatation values below 3.7%, the meanserum fibrinogen was of 295.50 ± 50.41 mg/dL, whereas for dilation valuesgreater than 13.03%, the mean was 229.41 ± 48.95 mg/dL (Figure 3).


Early Markers of Atherosclerotic Disease in Individuals with ExcessWeight and Dyslipidemia
Association between fibrinogen levels and brachial artery flow-mediateddilatation. BAFMD: Brachial artery flow-mediated dilatation
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4940144&req=5

f2: Association between fibrinogen levels and brachial artery flow-mediateddilatation. BAFMD: Brachial artery flow-mediated dilatation
Mentions: The biochemical results of the metabolic parameters and inflammatory markers weretreated as quantitative variables and their associations with the endothelialfunction were verified with Student's t test (Table 2). Fibrinogen was the only biochemicalparameter significantly associated with the endothelial function (p = 0.02) (Figure 2). When this association was evaluated byquartiles of dilation, we observed that for dilatation values below 3.7%, the meanserum fibrinogen was of 295.50 ± 50.41 mg/dL, whereas for dilation valuesgreater than 13.03%, the mean was 229.41 ± 48.95 mg/dL (Figure 3).

View Article: PubMed Central - PubMed

ABSTRACT

Background: Excessive weight is a cardiovascular risk factor since it generates a chronicinflammatory process that aggravates the endothelial function.

Objective: To evaluate the endothelial function in individuals with excess weight andmild dyslipidemia using brachial artery flow-mediated dilation (BAFMD), andthe association of endothelial function with anthropometric and biochemicalvariables.

Methods: Cross-sectional study that included 74 individuals and evaluatedanthropometric variables (body mass index [BMI], waist-hip ratio [WHR],waist circumference [AC], and percentage of body fat [PBF]), biochemical(blood glucose, insulinemia, ultrasensitive C-reactive protein, fibrinogen,total cholesterol, HDL-cholesterol, triglycerides, and LDL-cholesterol) andendothelial function (BAFMD, evaluated by ultrasound). The statisticalanalysis was performed with SPSS, version 16.0. To study the associationbetween the variables, we used chi-square, Student's t and Mann-Whitneytests, and Pearson's correlation. Logistic regression analyzed theindependent influence of the factors. Values of p < 0.05 were consideredsignificant.

Results: The participants had a mean age of 50.8 years, and 57% were female. BMI, WC,WHR, and PBF showed no significant association with BAFMD. The male gender(p = 0.02) and higher serum levels of fibrinogen (p = 0.02) weresignificantly and independently associated with a BAFMD below 8%.

Conclusions: In individuals with excess weight and mild untreated dyslipidemia, malegender and higher levels of fibrinogen were independently associated withworse BAFMD.

No MeSH data available.


Related in: MedlinePlus