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Overexpression of neuromedin U is correlated with regional metastasis of head and neck squamous cell carcinoma.

Wang L, Chen C, Li F, Hua QQ, Chen S, Xiao B, Dai M, Li M, Zheng A, Yu D, Hu ZW, Tao Z - Mol Med Rep (2016)

Bottom Line: The expression levels of Nmu in primary tumors with regional metastasis were higher, compared with those without metastasis.There was increased protein expression of Nmu in the advanced tumor tissues.The data obtained in the present study demonstrated that the expression of Nmu was correlated with regional metastasis and TNM status.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

ABSTRACT
Regional metastasis is an important prognostic factor for patients with head and neck squamous cell carcinoma (HNSCC). Neuromedin U (Nmu) is a secreted neuropeptide, named due to its potent uterine contraction‑inducing activity. The aim of the present study was to analyze the significance of Nmu in the regional metastasis of HNSCC. The characteristics of 240 patients recruited from the Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University (Wuhan, China) were summarized retrospectively. The positive rate of neck dissection was analyzed according to the material. The expression levels of Nmu in human tumor samples were analyzed using immunohistochemistry. Subsequently, the expression of Nmu was investigated using a tissue microassay to analyze the association between Nmu protein expression and Tumor Node Metastasis (TNM) status. The positive rate of neck dissection was 51.4% in the study sample. The expression levels of Nmu in primary tumors with regional metastasis were higher, compared with those without metastasis. There was increased protein expression of Nmu in the advanced tumor tissues. The data obtained in the present study demonstrated that the expression of Nmu was correlated with regional metastasis and TNM status. Overexpression of Nmu may be involved in the process of regional metastasis of HNSCC, and may serve as a novel and valuable biomarker for predicting regional metastasis in patients with HNSCC.

No MeSH data available.


Related in: MedlinePlus

Nmu microarray. (A) Map of the microarray. (B) Representative images of immunohistochemical staining of a head and neck cancer tissue micro-array with anti-Nmu antibody. This tissue microarray includes Ton, Lar and Nos carcinomas. NATs and normal tissue are also included. Nmu, neuromedin U; Ton, tongue; Lar, larynx; Nos, nose; liv, liver; NAT, normal adjacent tissue.
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f2-mmr-14-02-1075: Nmu microarray. (A) Map of the microarray. (B) Representative images of immunohistochemical staining of a head and neck cancer tissue micro-array with anti-Nmu antibody. This tissue microarray includes Ton, Lar and Nos carcinomas. NATs and normal tissue are also included. Nmu, neuromedin U; Ton, tongue; Lar, larynx; Nos, nose; liv, liver; NAT, normal adjacent tissue.

Mentions: Following completion of the analysis of Nmu using the clinical samples of HNSCC, A TMA, which contained three types of head and neck cancer (tongue, larynx and nose) was performed to provide a subset analysis, which also included normal tissues. As shown in Fig. 2, integral images of immunohistochemical staining of the TMA with an anti-Nmuantibody were captured. The immunohistochemical (IHC) score of every sample in the TMA was determined. The expression of Nmu among the T-stage, N-stage and grades of differentiation were compared, respectively.


Overexpression of neuromedin U is correlated with regional metastasis of head and neck squamous cell carcinoma.

Wang L, Chen C, Li F, Hua QQ, Chen S, Xiao B, Dai M, Li M, Zheng A, Yu D, Hu ZW, Tao Z - Mol Med Rep (2016)

Nmu microarray. (A) Map of the microarray. (B) Representative images of immunohistochemical staining of a head and neck cancer tissue micro-array with anti-Nmu antibody. This tissue microarray includes Ton, Lar and Nos carcinomas. NATs and normal tissue are also included. Nmu, neuromedin U; Ton, tongue; Lar, larynx; Nos, nose; liv, liver; NAT, normal adjacent tissue.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4940074&req=5

f2-mmr-14-02-1075: Nmu microarray. (A) Map of the microarray. (B) Representative images of immunohistochemical staining of a head and neck cancer tissue micro-array with anti-Nmu antibody. This tissue microarray includes Ton, Lar and Nos carcinomas. NATs and normal tissue are also included. Nmu, neuromedin U; Ton, tongue; Lar, larynx; Nos, nose; liv, liver; NAT, normal adjacent tissue.
Mentions: Following completion of the analysis of Nmu using the clinical samples of HNSCC, A TMA, which contained three types of head and neck cancer (tongue, larynx and nose) was performed to provide a subset analysis, which also included normal tissues. As shown in Fig. 2, integral images of immunohistochemical staining of the TMA with an anti-Nmuantibody were captured. The immunohistochemical (IHC) score of every sample in the TMA was determined. The expression of Nmu among the T-stage, N-stage and grades of differentiation were compared, respectively.

Bottom Line: The expression levels of Nmu in primary tumors with regional metastasis were higher, compared with those without metastasis.There was increased protein expression of Nmu in the advanced tumor tissues.The data obtained in the present study demonstrated that the expression of Nmu was correlated with regional metastasis and TNM status.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

ABSTRACT
Regional metastasis is an important prognostic factor for patients with head and neck squamous cell carcinoma (HNSCC). Neuromedin U (Nmu) is a secreted neuropeptide, named due to its potent uterine contraction‑inducing activity. The aim of the present study was to analyze the significance of Nmu in the regional metastasis of HNSCC. The characteristics of 240 patients recruited from the Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University (Wuhan, China) were summarized retrospectively. The positive rate of neck dissection was analyzed according to the material. The expression levels of Nmu in human tumor samples were analyzed using immunohistochemistry. Subsequently, the expression of Nmu was investigated using a tissue microassay to analyze the association between Nmu protein expression and Tumor Node Metastasis (TNM) status. The positive rate of neck dissection was 51.4% in the study sample. The expression levels of Nmu in primary tumors with regional metastasis were higher, compared with those without metastasis. There was increased protein expression of Nmu in the advanced tumor tissues. The data obtained in the present study demonstrated that the expression of Nmu was correlated with regional metastasis and TNM status. Overexpression of Nmu may be involved in the process of regional metastasis of HNSCC, and may serve as a novel and valuable biomarker for predicting regional metastasis in patients with HNSCC.

No MeSH data available.


Related in: MedlinePlus