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Cholinergic and perfusion brain networks in Parkinson disease dementia

View Article: PubMed Central - PubMed

ABSTRACT

Objective:: To investigate muscarinic M1/M4 cholinergic networks in Parkinson disease dementia (PDD) and their association with changes in Mini-Mental State Examination (MMSE) after 12 weeks of treatment with donepezil.

Methods:: Forty-nine participants (25 PDD and 24 elderly controls) underwent 123I-QNB and 99mTc-exametazime SPECT scanning. We implemented voxel principal components (PC) analysis, producing a series of PC images of patterns of interrelated voxels across individuals. Linear regression analyses derived specific M1/M4 and perfusion spatial covariance patterns (SCPs).

Results:: We found an M1/M4 SCP of relative decreased binding in basal forebrain, temporal, striatum, insula, and anterior cingulate (F1,47 = 31.9, p < 0.001) in cholinesterase inhibitor–naive patients with PDD, implicating limbic-paralimbic and salience cholinergic networks. The corresponding regional cerebral blood flow SCP showed relative decreased uptake in temporoparietal and prefrontal areas (F1,47 = 177.5, p < 0.001) and nodes of the frontoparietal and default mode networks (DMN). The M1/M4 pattern that correlated with an improvement in MMSE (r = 0.58, p = 0.005) revealed relatively preserved/increased pre/medial/orbitofrontal, parietal, and posterior cingulate areas coinciding with the DMN and frontoparietal networks.

Conclusion:: Dysfunctional limbic-paralimbic and salience cholinergic networks were associated with PDD. Established cholinergic maintenance of the DMN and frontoparietal networks may be prerequisite for cognitive remediation following cholinergic treatment in this condition.

No MeSH data available.


Related in: MedlinePlus

Regional cerebral blood flow (rCBF) spatial covariance pattern in Parkinson disease dementia (PDD)Disease-related rCBF spatial covariance pattern in PDD projected onto orthogonal (A) and rendered (B) displays of the rCBF template. Distribution of subject scaling factor (SSFrCBF) scores across groups (C). Ant = anterior; Pos = posterior; Sup = superior.
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Figure 2: Regional cerebral blood flow (rCBF) spatial covariance pattern in Parkinson disease dementia (PDD)Disease-related rCBF spatial covariance pattern in PDD projected onto orthogonal (A) and rendered (B) displays of the rCBF template. Distribution of subject scaling factor (SSFrCBF) scores across groups (C). Ant = anterior; Pos = posterior; Sup = superior.

Mentions: The associated SCPrCBF that differentiated PDD from controls is illustrated in figure 2, A and B , where SSFrCBF scores differed between groups (controls = 0.4 ± 0.9, PDD = 6.2 ± 1.9, F1,47 = 177.5, p < 0.001; figure 2C). The pattern mainly comprised relative decreased rCBF (blue) in temporoparietal and prefrontal areas with relative increases (red) in cerebellum, brainstem, striatothalamic, and motor regions. Detailed description of specific regions participating in the rCBF disease-related pattern is provided (table e-2).


Cholinergic and perfusion brain networks in Parkinson disease dementia
Regional cerebral blood flow (rCBF) spatial covariance pattern in Parkinson disease dementia (PDD)Disease-related rCBF spatial covariance pattern in PDD projected onto orthogonal (A) and rendered (B) displays of the rCBF template. Distribution of subject scaling factor (SSFrCBF) scores across groups (C). Ant = anterior; Pos = posterior; Sup = superior.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4940066&req=5

Figure 2: Regional cerebral blood flow (rCBF) spatial covariance pattern in Parkinson disease dementia (PDD)Disease-related rCBF spatial covariance pattern in PDD projected onto orthogonal (A) and rendered (B) displays of the rCBF template. Distribution of subject scaling factor (SSFrCBF) scores across groups (C). Ant = anterior; Pos = posterior; Sup = superior.
Mentions: The associated SCPrCBF that differentiated PDD from controls is illustrated in figure 2, A and B , where SSFrCBF scores differed between groups (controls = 0.4 ± 0.9, PDD = 6.2 ± 1.9, F1,47 = 177.5, p < 0.001; figure 2C). The pattern mainly comprised relative decreased rCBF (blue) in temporoparietal and prefrontal areas with relative increases (red) in cerebellum, brainstem, striatothalamic, and motor regions. Detailed description of specific regions participating in the rCBF disease-related pattern is provided (table e-2).

View Article: PubMed Central - PubMed

ABSTRACT

Objective:: To investigate muscarinic M1/M4 cholinergic networks in Parkinson disease dementia (PDD) and their association with changes in Mini-Mental State Examination (MMSE) after 12 weeks of treatment with donepezil.

Methods:: Forty-nine participants (25 PDD and 24 elderly controls) underwent 123I-QNB and 99mTc-exametazime SPECT scanning. We implemented voxel principal components (PC) analysis, producing a series of PC images of patterns of interrelated voxels across individuals. Linear regression analyses derived specific M1/M4 and perfusion spatial covariance patterns (SCPs).

Results:: We found an M1/M4 SCP of relative decreased binding in basal forebrain, temporal, striatum, insula, and anterior cingulate (F1,47 = 31.9, p &lt; 0.001) in cholinesterase inhibitor&ndash;naive patients with PDD, implicating limbic-paralimbic and salience cholinergic networks. The corresponding regional cerebral blood flow SCP showed relative decreased uptake in temporoparietal and prefrontal areas (F1,47 = 177.5, p &lt; 0.001) and nodes of the frontoparietal and default mode networks (DMN). The M1/M4 pattern that correlated with an improvement in MMSE (r = 0.58, p = 0.005) revealed relatively preserved/increased pre/medial/orbitofrontal, parietal, and posterior cingulate areas coinciding with the DMN and frontoparietal networks.

Conclusion:: Dysfunctional limbic-paralimbic and salience cholinergic networks were associated with PDD. Established cholinergic maintenance of the DMN and frontoparietal networks may be prerequisite for cognitive remediation following cholinergic treatment in this condition.

No MeSH data available.


Related in: MedlinePlus