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Polymorphism in IGFBP3 gene is associated with prostate cancer risk: an updated meta-analysis.

Qie Y, Nian X, Liu X, Hu H, Zhang C, Xie L, Han R, Wu C, Xu Y - Onco Targets Ther (2016)

Bottom Line: Further stratification analysis revealed that the association between -202A/C polymorphism and PCa risk among Caucasians, but not in other ethnicities, was statistically significant (recessive model, OR =1.10, 95% CI: 1.02-1.19).In addition, the IGFBP3-202A/C polymorphism was associated with PCa risk in both population-based and hospital-based studies in homozygote comparison, recessive model, and allele model.Our meta-analysis indicates that the IGFBP3-202A/C polymorphism is associated with the risk of PCa, particularly in Caucasians, with the C allele being the risk allele for PCa.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology.

ABSTRACT

Objective: Insulin-like growth factor-binding protein-3 (IGFBP3) is the major protein that binds with insulin-like growth factor-1 (IGF-1) and is considered to be involved in the development and progression of various cancers. We aimed to examine the association between prostate cancer (PCa) and the IGFBP3 gene-202A/C polymorphism.

Methods: A comprehensive search within PubMed, EMBASE, and Cochrane Library was conducted to identify all case-control studies up to October 30, 2015, for a meta-analysis. Pooled odds ratios (ORs) and the 95% confidence intervals (CIs) were calculated using the fixed or random effects model.

Results: Eighteen studies including 10,538 cases and 10,078 controls were identified. Overall, the CC genotype of IGFBP3-202A/C polymorphism was associated with increased risk of PCa in homozygote comparison (CC vs AA - OR =1.16, 95% CI: 1.08-1.25) and in recessive model (CC vs AA+AC - OR =1.11, 95% CI: 1.04-1.17). In dominant model, the CC/AC genotypes also implicated an increased risk of PCa (CC+AC vs AA - OR =1.11, 95% CI: 1.05-1.19). The C allele of IGFBP3-202A/C polymorphism was the risk allele for PCa relative to the A allele (OR =1.09, 95% CI: 1.05-1.14). Further stratification analysis revealed that the association between -202A/C polymorphism and PCa risk among Caucasians, but not in other ethnicities, was statistically significant (recessive model, OR =1.10, 95% CI: 1.02-1.19). In addition, the IGFBP3-202A/C polymorphism was associated with PCa risk in both population-based and hospital-based studies in homozygote comparison, recessive model, and allele model.

Conclusion: Our meta-analysis indicates that the IGFBP3-202A/C polymorphism is associated with the risk of PCa, particularly in Caucasians, with the C allele being the risk allele for PCa.

No MeSH data available.


Related in: MedlinePlus

Forest plot of odds ratios with 95% confidence interval for IGFBP3-202A/C polymorphism and risk of prostate cancer risk under recessive model (CC+AC vs AA).Abbreviations: IGFBP3, insulin-like growth factor-binding protein-3; OR, odds ratio; CI, confidence interval.
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f4-ott-9-4163: Forest plot of odds ratios with 95% confidence interval for IGFBP3-202A/C polymorphism and risk of prostate cancer risk under recessive model (CC+AC vs AA).Abbreviations: IGFBP3, insulin-like growth factor-binding protein-3; OR, odds ratio; CI, confidence interval.

Mentions: Q-test of heterogeneity was conducted for overall homozygote comparison, heterozygote comparison, dominant model, recessive model, and allele model, respectively, which turned out that I2 value was <50% in all these cases. Thus, a fixed effects model was used to calculate values. Overall, the CC genotype of IGFBP3-202A/C polymorphism was associated with increased risk of PCa in homozygote comparison (CC vs AA − OR =1.16, 95% CI: 1.08–1.25, I2=28.7%; Figure 2) and in recessive model (CC vs AA+AC − OR =1.11, 95% CI: 1.04–1.17, I2=1.10%; Figure 3). In dominant model, the CC/AC genotypes implicated an increased risk of PCa (CC+AC vs AA − OR =1.11, 95% CI: 1.05–1.19, I2=28.5%; Figure 4). The C allele of IGFBP3-202A/C polymorphism was the risk allele for PCa relative to the A allele (OR =1.09, 95% CI: 1.05–1.14, I2=32.90%; Figure 5).


Polymorphism in IGFBP3 gene is associated with prostate cancer risk: an updated meta-analysis.

Qie Y, Nian X, Liu X, Hu H, Zhang C, Xie L, Han R, Wu C, Xu Y - Onco Targets Ther (2016)

Forest plot of odds ratios with 95% confidence interval for IGFBP3-202A/C polymorphism and risk of prostate cancer risk under recessive model (CC+AC vs AA).Abbreviations: IGFBP3, insulin-like growth factor-binding protein-3; OR, odds ratio; CI, confidence interval.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4940022&req=5

f4-ott-9-4163: Forest plot of odds ratios with 95% confidence interval for IGFBP3-202A/C polymorphism and risk of prostate cancer risk under recessive model (CC+AC vs AA).Abbreviations: IGFBP3, insulin-like growth factor-binding protein-3; OR, odds ratio; CI, confidence interval.
Mentions: Q-test of heterogeneity was conducted for overall homozygote comparison, heterozygote comparison, dominant model, recessive model, and allele model, respectively, which turned out that I2 value was <50% in all these cases. Thus, a fixed effects model was used to calculate values. Overall, the CC genotype of IGFBP3-202A/C polymorphism was associated with increased risk of PCa in homozygote comparison (CC vs AA − OR =1.16, 95% CI: 1.08–1.25, I2=28.7%; Figure 2) and in recessive model (CC vs AA+AC − OR =1.11, 95% CI: 1.04–1.17, I2=1.10%; Figure 3). In dominant model, the CC/AC genotypes implicated an increased risk of PCa (CC+AC vs AA − OR =1.11, 95% CI: 1.05–1.19, I2=28.5%; Figure 4). The C allele of IGFBP3-202A/C polymorphism was the risk allele for PCa relative to the A allele (OR =1.09, 95% CI: 1.05–1.14, I2=32.90%; Figure 5).

Bottom Line: Further stratification analysis revealed that the association between -202A/C polymorphism and PCa risk among Caucasians, but not in other ethnicities, was statistically significant (recessive model, OR =1.10, 95% CI: 1.02-1.19).In addition, the IGFBP3-202A/C polymorphism was associated with PCa risk in both population-based and hospital-based studies in homozygote comparison, recessive model, and allele model.Our meta-analysis indicates that the IGFBP3-202A/C polymorphism is associated with the risk of PCa, particularly in Caucasians, with the C allele being the risk allele for PCa.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology.

ABSTRACT

Objective: Insulin-like growth factor-binding protein-3 (IGFBP3) is the major protein that binds with insulin-like growth factor-1 (IGF-1) and is considered to be involved in the development and progression of various cancers. We aimed to examine the association between prostate cancer (PCa) and the IGFBP3 gene-202A/C polymorphism.

Methods: A comprehensive search within PubMed, EMBASE, and Cochrane Library was conducted to identify all case-control studies up to October 30, 2015, for a meta-analysis. Pooled odds ratios (ORs) and the 95% confidence intervals (CIs) were calculated using the fixed or random effects model.

Results: Eighteen studies including 10,538 cases and 10,078 controls were identified. Overall, the CC genotype of IGFBP3-202A/C polymorphism was associated with increased risk of PCa in homozygote comparison (CC vs AA - OR =1.16, 95% CI: 1.08-1.25) and in recessive model (CC vs AA+AC - OR =1.11, 95% CI: 1.04-1.17). In dominant model, the CC/AC genotypes also implicated an increased risk of PCa (CC+AC vs AA - OR =1.11, 95% CI: 1.05-1.19). The C allele of IGFBP3-202A/C polymorphism was the risk allele for PCa relative to the A allele (OR =1.09, 95% CI: 1.05-1.14). Further stratification analysis revealed that the association between -202A/C polymorphism and PCa risk among Caucasians, but not in other ethnicities, was statistically significant (recessive model, OR =1.10, 95% CI: 1.02-1.19). In addition, the IGFBP3-202A/C polymorphism was associated with PCa risk in both population-based and hospital-based studies in homozygote comparison, recessive model, and allele model.

Conclusion: Our meta-analysis indicates that the IGFBP3-202A/C polymorphism is associated with the risk of PCa, particularly in Caucasians, with the C allele being the risk allele for PCa.

No MeSH data available.


Related in: MedlinePlus