Limits...
Polymorphism in IGFBP3 gene is associated with prostate cancer risk: an updated meta-analysis.

Qie Y, Nian X, Liu X, Hu H, Zhang C, Xie L, Han R, Wu C, Xu Y - Onco Targets Ther (2016)

Bottom Line: Further stratification analysis revealed that the association between -202A/C polymorphism and PCa risk among Caucasians, but not in other ethnicities, was statistically significant (recessive model, OR =1.10, 95% CI: 1.02-1.19).In addition, the IGFBP3-202A/C polymorphism was associated with PCa risk in both population-based and hospital-based studies in homozygote comparison, recessive model, and allele model.Our meta-analysis indicates that the IGFBP3-202A/C polymorphism is associated with the risk of PCa, particularly in Caucasians, with the C allele being the risk allele for PCa.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology.

ABSTRACT

Objective: Insulin-like growth factor-binding protein-3 (IGFBP3) is the major protein that binds with insulin-like growth factor-1 (IGF-1) and is considered to be involved in the development and progression of various cancers. We aimed to examine the association between prostate cancer (PCa) and the IGFBP3 gene-202A/C polymorphism.

Methods: A comprehensive search within PubMed, EMBASE, and Cochrane Library was conducted to identify all case-control studies up to October 30, 2015, for a meta-analysis. Pooled odds ratios (ORs) and the 95% confidence intervals (CIs) were calculated using the fixed or random effects model.

Results: Eighteen studies including 10,538 cases and 10,078 controls were identified. Overall, the CC genotype of IGFBP3-202A/C polymorphism was associated with increased risk of PCa in homozygote comparison (CC vs AA - OR =1.16, 95% CI: 1.08-1.25) and in recessive model (CC vs AA+AC - OR =1.11, 95% CI: 1.04-1.17). In dominant model, the CC/AC genotypes also implicated an increased risk of PCa (CC+AC vs AA - OR =1.11, 95% CI: 1.05-1.19). The C allele of IGFBP3-202A/C polymorphism was the risk allele for PCa relative to the A allele (OR =1.09, 95% CI: 1.05-1.14). Further stratification analysis revealed that the association between -202A/C polymorphism and PCa risk among Caucasians, but not in other ethnicities, was statistically significant (recessive model, OR =1.10, 95% CI: 1.02-1.19). In addition, the IGFBP3-202A/C polymorphism was associated with PCa risk in both population-based and hospital-based studies in homozygote comparison, recessive model, and allele model.

Conclusion: Our meta-analysis indicates that the IGFBP3-202A/C polymorphism is associated with the risk of PCa, particularly in Caucasians, with the C allele being the risk allele for PCa.

No MeSH data available.


Related in: MedlinePlus

Flowchart of studies included in the meta-analysis.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4940022&req=5

f1-ott-9-4163: Flowchart of studies included in the meta-analysis.

Mentions: A total of 377 studies that investigated the association of IGFBP3 with PCa risk were identified and screened for data retrieval. As shown in Figure 1, after the exclusion of overlapping data, 353 studies were shortlisted for meta-analysis. Further, 308 papers were excluded as they were not relevant to IGFBP3 polymorphism and PCa, and thus 45 studies were available for further review. Of these 45 studies, 28 studies were excluded because they were reviews or meta-analyses or studies, which were not conducted in human subjects or not relevant to IGFBP3-202A/C polymorphism. Among the 17 full-text papers, four studies did not provide sufficient data needed for OR calculation; one had no controls and one was not in English. We thus included 12 independent studies13–23,26 that enabled data extraction for the present meta-analysis. Since three studies19–21 had more than one subpopulation, we treated every subpopulation as an independent study. Therefore, 18 separate studies in total were available for our meta-analysis, which included 10,538 cases and 10,078 controls. The main features of these studies are summarized in Table 1. The IGFBP3-202A/C polymorphism was reported by four studies in African Americans, four studies in Asians, six studies in Caucasians, one study in Hawaiians, and one study in Latinos. The HWE deviated (P<0.01) in three studies in the control group15,17,19 and were further tested for sensitivity analysis.


Polymorphism in IGFBP3 gene is associated with prostate cancer risk: an updated meta-analysis.

Qie Y, Nian X, Liu X, Hu H, Zhang C, Xie L, Han R, Wu C, Xu Y - Onco Targets Ther (2016)

Flowchart of studies included in the meta-analysis.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4940022&req=5

f1-ott-9-4163: Flowchart of studies included in the meta-analysis.
Mentions: A total of 377 studies that investigated the association of IGFBP3 with PCa risk were identified and screened for data retrieval. As shown in Figure 1, after the exclusion of overlapping data, 353 studies were shortlisted for meta-analysis. Further, 308 papers were excluded as they were not relevant to IGFBP3 polymorphism and PCa, and thus 45 studies were available for further review. Of these 45 studies, 28 studies were excluded because they were reviews or meta-analyses or studies, which were not conducted in human subjects or not relevant to IGFBP3-202A/C polymorphism. Among the 17 full-text papers, four studies did not provide sufficient data needed for OR calculation; one had no controls and one was not in English. We thus included 12 independent studies13–23,26 that enabled data extraction for the present meta-analysis. Since three studies19–21 had more than one subpopulation, we treated every subpopulation as an independent study. Therefore, 18 separate studies in total were available for our meta-analysis, which included 10,538 cases and 10,078 controls. The main features of these studies are summarized in Table 1. The IGFBP3-202A/C polymorphism was reported by four studies in African Americans, four studies in Asians, six studies in Caucasians, one study in Hawaiians, and one study in Latinos. The HWE deviated (P<0.01) in three studies in the control group15,17,19 and were further tested for sensitivity analysis.

Bottom Line: Further stratification analysis revealed that the association between -202A/C polymorphism and PCa risk among Caucasians, but not in other ethnicities, was statistically significant (recessive model, OR =1.10, 95% CI: 1.02-1.19).In addition, the IGFBP3-202A/C polymorphism was associated with PCa risk in both population-based and hospital-based studies in homozygote comparison, recessive model, and allele model.Our meta-analysis indicates that the IGFBP3-202A/C polymorphism is associated with the risk of PCa, particularly in Caucasians, with the C allele being the risk allele for PCa.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology.

ABSTRACT

Objective: Insulin-like growth factor-binding protein-3 (IGFBP3) is the major protein that binds with insulin-like growth factor-1 (IGF-1) and is considered to be involved in the development and progression of various cancers. We aimed to examine the association between prostate cancer (PCa) and the IGFBP3 gene-202A/C polymorphism.

Methods: A comprehensive search within PubMed, EMBASE, and Cochrane Library was conducted to identify all case-control studies up to October 30, 2015, for a meta-analysis. Pooled odds ratios (ORs) and the 95% confidence intervals (CIs) were calculated using the fixed or random effects model.

Results: Eighteen studies including 10,538 cases and 10,078 controls were identified. Overall, the CC genotype of IGFBP3-202A/C polymorphism was associated with increased risk of PCa in homozygote comparison (CC vs AA - OR =1.16, 95% CI: 1.08-1.25) and in recessive model (CC vs AA+AC - OR =1.11, 95% CI: 1.04-1.17). In dominant model, the CC/AC genotypes also implicated an increased risk of PCa (CC+AC vs AA - OR =1.11, 95% CI: 1.05-1.19). The C allele of IGFBP3-202A/C polymorphism was the risk allele for PCa relative to the A allele (OR =1.09, 95% CI: 1.05-1.14). Further stratification analysis revealed that the association between -202A/C polymorphism and PCa risk among Caucasians, but not in other ethnicities, was statistically significant (recessive model, OR =1.10, 95% CI: 1.02-1.19). In addition, the IGFBP3-202A/C polymorphism was associated with PCa risk in both population-based and hospital-based studies in homozygote comparison, recessive model, and allele model.

Conclusion: Our meta-analysis indicates that the IGFBP3-202A/C polymorphism is associated with the risk of PCa, particularly in Caucasians, with the C allele being the risk allele for PCa.

No MeSH data available.


Related in: MedlinePlus