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The effects of ferulic acid on the pharmacokinetics of warfarin in rats after biliary drainage.

Li H, Wang Y, Fan R, Lv H, Sun H, Xie H, Tang T, Luo J, Xia Z - Drug Des Devel Ther (2016)

Bottom Line: Comparisons between groups were performed according to the main pharmacokinetic parameters calculated by the DAS 2.1.1 software.The pharmacokinetic parameters showed a significant difference between the WN and WO groups, the WO group showed a decrease of 51% and 41.6% in area under the curve from 0 to time (AUC0- t ) and peak plasma concentration (C max), respectively, whereas time to C max (T max) was delayed 3.27 folds.There were significant differences between the WFO and WFN groups, the WFO group showed a decrease of 63.8% and 70% in AUC0- t and C max, respectively; the delay in T max between the WN and WFN groups (mean, from 132-432 minutes) was significantly different; the mean retention time from 0 to time (MRT0- t ) between the WO and WFO groups (mean, from 718.31-606.13 minutes) also showed a significant difference.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrated Traditional Chinese and Western Medicine, Laboratory of Ethnopharmacology, Xiangya Hospital, Central South University; Department of Pharmacy, Changsha Medical University.

ABSTRACT
According to previous research studies, warfarin can be detected in human bile after oral administration. Ferulic acid (FA) is the main bioactive component of many Chinese herbs for the treatment of cardiovascular disease. To elucidate the effects of FA on the pharmacokinetics of warfarin in rats after biliary drainage is necessary. Twenty rats were randomly divided into four groups: Group 1 (WN): healthy rats after the administration of warfarin sodium, Group 2 (WO): a rat model of biliary drainage after the administration of warfarin sodium, Group 3 (WFN): healthy rats after the administration of warfarin sodium and FA, and Group 4 (WFO): a rat model of biliary drainage after the administration of warfarin sodium and FA. Blood samples were collected at different time points after administration. The concentrations of blood samples were determined by ultraperformance liquid chromatography-tandem mass spectrometry. Comparisons between groups were performed according to the main pharmacokinetic parameters calculated by the DAS 2.1.1 software. The pharmacokinetic parameters showed a significant difference between the WN and WO groups, the WO group showed a decrease of 51% and 41.6% in area under the curve from 0 to time (AUC0- t ) and peak plasma concentration (C max), respectively, whereas time to C max (T max) was delayed 3.27 folds. There were significant differences between the WFO and WFN groups, the WFO group showed a decrease of 63.8% and 70% in AUC0- t and C max, respectively; the delay in T max between the WN and WFN groups (mean, from 132-432 minutes) was significantly different; the mean retention time from 0 to time (MRT0- t ) between the WO and WFO groups (mean, from 718.31-606.13 minutes) also showed a significant difference. Enterohepatic circulation markedly influences the disposition of warfarin in rats, and FA significantly affected the warfarin disposition in rat plasma.

No MeSH data available.


Related in: MedlinePlus

Enterohepatic circulation (EHC), the circulation of bile acid after oral administration.Notes: (1) Warfarin enters the gastrointestinal tract after oral administration; (2) warfarin in the gastrointestinal tract enters the liver via the portal vein; (3) some of the warfarin in the liver is secreted into the bile duct; (4) warfarin in the bile duct enters the gastrointestinal tract through the duodenum; and (5) warfarin in the gastrointestinal tract is reabsorbed and transported back to the liver for systemic circulation.
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f1-dddt-10-2173: Enterohepatic circulation (EHC), the circulation of bile acid after oral administration.Notes: (1) Warfarin enters the gastrointestinal tract after oral administration; (2) warfarin in the gastrointestinal tract enters the liver via the portal vein; (3) some of the warfarin in the liver is secreted into the bile duct; (4) warfarin in the bile duct enters the gastrointestinal tract through the duodenum; and (5) warfarin in the gastrointestinal tract is reabsorbed and transported back to the liver for systemic circulation.

Mentions: Ferulic acid (FA), a hydroxycinnamic acid (Figure 1), is ubiquitous and abundant in many plants11 and even some vegetables.12 FA is the main active constituent of Angelicae Sinensis Radix (the root of Angelica sinensis [Oliv] Diels)13 and Chuanxiong Rhizoma (rhizomes of Ligusticum chuanxiong Hort). According to the traditional Chinese medicine (TCM) theory, the pharmacological action of FA is “to activate the blood circulation and to dissipate blood stasis”, which is similar to the antiplatelet aggregation,14 anticoagulation, inhibiting erythrocyte agglutination,15 and vasodilation16 effects of FA. Previous studies showed that some active components of Chinese herbal medicine, including tanshinone IIA17 and ginsenosides,18 could influence the pharmacokinetics of warfarin. However, the effects of FA on the pharmacokinetics of warfarin remain unknown.


The effects of ferulic acid on the pharmacokinetics of warfarin in rats after biliary drainage.

Li H, Wang Y, Fan R, Lv H, Sun H, Xie H, Tang T, Luo J, Xia Z - Drug Des Devel Ther (2016)

Enterohepatic circulation (EHC), the circulation of bile acid after oral administration.Notes: (1) Warfarin enters the gastrointestinal tract after oral administration; (2) warfarin in the gastrointestinal tract enters the liver via the portal vein; (3) some of the warfarin in the liver is secreted into the bile duct; (4) warfarin in the bile duct enters the gastrointestinal tract through the duodenum; and (5) warfarin in the gastrointestinal tract is reabsorbed and transported back to the liver for systemic circulation.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4940002&req=5

f1-dddt-10-2173: Enterohepatic circulation (EHC), the circulation of bile acid after oral administration.Notes: (1) Warfarin enters the gastrointestinal tract after oral administration; (2) warfarin in the gastrointestinal tract enters the liver via the portal vein; (3) some of the warfarin in the liver is secreted into the bile duct; (4) warfarin in the bile duct enters the gastrointestinal tract through the duodenum; and (5) warfarin in the gastrointestinal tract is reabsorbed and transported back to the liver for systemic circulation.
Mentions: Ferulic acid (FA), a hydroxycinnamic acid (Figure 1), is ubiquitous and abundant in many plants11 and even some vegetables.12 FA is the main active constituent of Angelicae Sinensis Radix (the root of Angelica sinensis [Oliv] Diels)13 and Chuanxiong Rhizoma (rhizomes of Ligusticum chuanxiong Hort). According to the traditional Chinese medicine (TCM) theory, the pharmacological action of FA is “to activate the blood circulation and to dissipate blood stasis”, which is similar to the antiplatelet aggregation,14 anticoagulation, inhibiting erythrocyte agglutination,15 and vasodilation16 effects of FA. Previous studies showed that some active components of Chinese herbal medicine, including tanshinone IIA17 and ginsenosides,18 could influence the pharmacokinetics of warfarin. However, the effects of FA on the pharmacokinetics of warfarin remain unknown.

Bottom Line: Comparisons between groups were performed according to the main pharmacokinetic parameters calculated by the DAS 2.1.1 software.The pharmacokinetic parameters showed a significant difference between the WN and WO groups, the WO group showed a decrease of 51% and 41.6% in area under the curve from 0 to time (AUC0- t ) and peak plasma concentration (C max), respectively, whereas time to C max (T max) was delayed 3.27 folds.There were significant differences between the WFO and WFN groups, the WFO group showed a decrease of 63.8% and 70% in AUC0- t and C max, respectively; the delay in T max between the WN and WFN groups (mean, from 132-432 minutes) was significantly different; the mean retention time from 0 to time (MRT0- t ) between the WO and WFO groups (mean, from 718.31-606.13 minutes) also showed a significant difference.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrated Traditional Chinese and Western Medicine, Laboratory of Ethnopharmacology, Xiangya Hospital, Central South University; Department of Pharmacy, Changsha Medical University.

ABSTRACT
According to previous research studies, warfarin can be detected in human bile after oral administration. Ferulic acid (FA) is the main bioactive component of many Chinese herbs for the treatment of cardiovascular disease. To elucidate the effects of FA on the pharmacokinetics of warfarin in rats after biliary drainage is necessary. Twenty rats were randomly divided into four groups: Group 1 (WN): healthy rats after the administration of warfarin sodium, Group 2 (WO): a rat model of biliary drainage after the administration of warfarin sodium, Group 3 (WFN): healthy rats after the administration of warfarin sodium and FA, and Group 4 (WFO): a rat model of biliary drainage after the administration of warfarin sodium and FA. Blood samples were collected at different time points after administration. The concentrations of blood samples were determined by ultraperformance liquid chromatography-tandem mass spectrometry. Comparisons between groups were performed according to the main pharmacokinetic parameters calculated by the DAS 2.1.1 software. The pharmacokinetic parameters showed a significant difference between the WN and WO groups, the WO group showed a decrease of 51% and 41.6% in area under the curve from 0 to time (AUC0- t ) and peak plasma concentration (C max), respectively, whereas time to C max (T max) was delayed 3.27 folds. There were significant differences between the WFO and WFN groups, the WFO group showed a decrease of 63.8% and 70% in AUC0- t and C max, respectively; the delay in T max between the WN and WFN groups (mean, from 132-432 minutes) was significantly different; the mean retention time from 0 to time (MRT0- t ) between the WO and WFO groups (mean, from 718.31-606.13 minutes) also showed a significant difference. Enterohepatic circulation markedly influences the disposition of warfarin in rats, and FA significantly affected the warfarin disposition in rat plasma.

No MeSH data available.


Related in: MedlinePlus