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Flow diverter effect of LVIS stent on cerebral aneurysm hemodynamics: a comparison with Enterprise stents and the Pipeline device.

Wang C, Tian Z, Liu J, Jing L, Paliwal N, Wang S, Zhang Y, Xiang J, Siddiqui AH, Meng H, Yang X - J Transl Med (2016)

Bottom Line: A single Pipeline showed less reduction in WSS (51.08 %) and velocity (37.87 %) compared with double-LVIS stent.We found that the LVIS stent has certain hemodynamic effects on cerebral aneurysms: a single LVIS stent caused more flow reductions than the double-Enterprise stent but less than a Pipeline device.Nevertheless, the double-LVIS stent resulted in a better flow diverting effect than a Pipeline device.

View Article: PubMed Central - PubMed

Affiliation: Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tian Tan Hospital, Capital Medical University, TiantanXili 6, Dongcheng District, Beijing, China.

ABSTRACT

Background: The aim of this study was to quantify the effect of the new Low-profile Visualized Intraluminal Support (LVIS®D) device and the difference of fluid diverting effect compared with the Pipeline device and the Enterprise stent using computational fluid dynamics (CFD).

Methods: In this research, we simulated three aneurysms constructed from 3D digital subtraction angiography (DSA). The Enterprise, LVIS and the Pipeline device were virtually conformed to fit into the vessel lumen and placed across the aneurysm orifice. Computational fluid dynamics analysis was performed to compare the hemodynamic differences such as WSS, Velocity and Pressure among these stents.

Results: Control referred to the unstented model, the percentage of hemodynamic changes were all compared to Control. A single LVIS stent caused more wall shear stress reduction than double Enterprise stents (39.96 vs. 30.51 %) and velocity (23.13 vs. 18.64 %). Significant reduction in wall shear stress (63.88 %) and velocity (46.05 %) was observed in the double-LVIS stents. A single Pipeline showed less reduction in WSS (51.08 %) and velocity (37.87 %) compared with double-LVIS stent. The double-Pipeline stents resulted in the most reduction in WSS (72.37 %) and velocity (54.26 %). Moreover, the pressure increased with minuscule extent after stenting, compared with the unstented model.

Conclusions: This is the first study analyzing flow modifications associated with LVIS stents. We found that the LVIS stent has certain hemodynamic effects on cerebral aneurysms: a single LVIS stent caused more flow reductions than the double-Enterprise stent but less than a Pipeline device. Nevertheless, the double-LVIS stent resulted in a better flow diverting effect than a Pipeline device.

No MeSH data available.


Related in: MedlinePlus

The enlarged stent cells of overlapping stents. The enlarged blue wires of the first deployed stent and the enlarged grey wires of the second deployed stent were shown in the Geomagic Studio software. a The overlapping stents were staggered well; b the overlapping stents were not well staggered (disordered or overlapped)
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Fig2: The enlarged stent cells of overlapping stents. The enlarged blue wires of the first deployed stent and the enlarged grey wires of the second deployed stent were shown in the Geomagic Studio software. a The overlapping stents were staggered well; b the overlapping stents were not well staggered (disordered or overlapped)

Mentions: Geometries of aneurysm models of 3 cases after stent placement. a A single-Enterprise stent model; b double-Enterprise stent model; c a single-LVIS stent model; d double-LVIS stent model; e a single-Pipeline device model; f double-Pipeline device model


Flow diverter effect of LVIS stent on cerebral aneurysm hemodynamics: a comparison with Enterprise stents and the Pipeline device.

Wang C, Tian Z, Liu J, Jing L, Paliwal N, Wang S, Zhang Y, Xiang J, Siddiqui AH, Meng H, Yang X - J Transl Med (2016)

The enlarged stent cells of overlapping stents. The enlarged blue wires of the first deployed stent and the enlarged grey wires of the second deployed stent were shown in the Geomagic Studio software. a The overlapping stents were staggered well; b the overlapping stents were not well staggered (disordered or overlapped)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4930570&req=5

Fig2: The enlarged stent cells of overlapping stents. The enlarged blue wires of the first deployed stent and the enlarged grey wires of the second deployed stent were shown in the Geomagic Studio software. a The overlapping stents were staggered well; b the overlapping stents were not well staggered (disordered or overlapped)
Mentions: Geometries of aneurysm models of 3 cases after stent placement. a A single-Enterprise stent model; b double-Enterprise stent model; c a single-LVIS stent model; d double-LVIS stent model; e a single-Pipeline device model; f double-Pipeline device model

Bottom Line: A single Pipeline showed less reduction in WSS (51.08 %) and velocity (37.87 %) compared with double-LVIS stent.We found that the LVIS stent has certain hemodynamic effects on cerebral aneurysms: a single LVIS stent caused more flow reductions than the double-Enterprise stent but less than a Pipeline device.Nevertheless, the double-LVIS stent resulted in a better flow diverting effect than a Pipeline device.

View Article: PubMed Central - PubMed

Affiliation: Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tian Tan Hospital, Capital Medical University, TiantanXili 6, Dongcheng District, Beijing, China.

ABSTRACT

Background: The aim of this study was to quantify the effect of the new Low-profile Visualized Intraluminal Support (LVIS®D) device and the difference of fluid diverting effect compared with the Pipeline device and the Enterprise stent using computational fluid dynamics (CFD).

Methods: In this research, we simulated three aneurysms constructed from 3D digital subtraction angiography (DSA). The Enterprise, LVIS and the Pipeline device were virtually conformed to fit into the vessel lumen and placed across the aneurysm orifice. Computational fluid dynamics analysis was performed to compare the hemodynamic differences such as WSS, Velocity and Pressure among these stents.

Results: Control referred to the unstented model, the percentage of hemodynamic changes were all compared to Control. A single LVIS stent caused more wall shear stress reduction than double Enterprise stents (39.96 vs. 30.51 %) and velocity (23.13 vs. 18.64 %). Significant reduction in wall shear stress (63.88 %) and velocity (46.05 %) was observed in the double-LVIS stents. A single Pipeline showed less reduction in WSS (51.08 %) and velocity (37.87 %) compared with double-LVIS stent. The double-Pipeline stents resulted in the most reduction in WSS (72.37 %) and velocity (54.26 %). Moreover, the pressure increased with minuscule extent after stenting, compared with the unstented model.

Conclusions: This is the first study analyzing flow modifications associated with LVIS stents. We found that the LVIS stent has certain hemodynamic effects on cerebral aneurysms: a single LVIS stent caused more flow reductions than the double-Enterprise stent but less than a Pipeline device. Nevertheless, the double-LVIS stent resulted in a better flow diverting effect than a Pipeline device.

No MeSH data available.


Related in: MedlinePlus