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A "twisted" microfluidic mixer suitable for a wide range of flow rate applications.

Sivashankar S, Agambayev S, Mashraei Y, Li EQ, Thoroddsen ST, Salama KN - Biomicrofluidics (2016)

Bottom Line: The efficiency of mixing was calculated within the channel by acquiring intensities using ImageJ software.Results suggested that efficient mixing can be obtained when more than 3 units were consecutively placed.The geometry of the device, which has a length of 30 mm, enables the device to be integrated with micro total analysis systems and other lab-on-chip devices.

View Article: PubMed Central - PubMed

Affiliation: Computer, Electrical and Mathematical Science and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST) , Thuwal, Saudi Arabia.

ABSTRACT
This paper proposes a new "twisted" 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamination of mixer units provides the splitting and recombination mechanism when the quadrant of circles is arranged in a two-layered serial arrangement of mixing units. The overall 3D path of the microchannel introduces the advection. An experimental investigation using chemical solutions revealed that these novel 3D passive microfluidic mixers were stable and could be operated at a wide range of flow rates. This micromixer finds application in the manipulation of tiny volumes of liquids that are crucial in diagnostics. The mixing performance was evaluated by dye visualization, and using a pH test that determined the chemical reaction of the solutions. A comparison of the tornado-mixer with this twisted micromixer was made to evaluate the efficiency of mixing. The efficiency of mixing was calculated within the channel by acquiring intensities using ImageJ software. Results suggested that efficient mixing can be obtained when more than 3 units were consecutively placed. The geometry of the device, which has a length of 30 mm, enables the device to be integrated with micro total analysis systems and other lab-on-chip devices.

No MeSH data available.


Related in: MedlinePlus

Simulation results (a) design and concentration profile of the 3D mixer, with an enlarged view of the first 3 units showing the concentration profiles varying in the units (b) flow concentration profiles at cross sections for the first 3 units.
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f3: Simulation results (a) design and concentration profile of the 3D mixer, with an enlarged view of the first 3 units showing the concentration profiles varying in the units (b) flow concentration profiles at cross sections for the first 3 units.

Mentions: Simulations were performed with the COMSOL Multiphysics commercial software (COMSOL 5.2) in order to quantify the mixing performance of the micromixer. The mixing profile within the unit was investigated using 3D models, as depicted in Fig. 1. In the numerical simulation models, the type of the fluid used was an incompressible Newton fluid governed by the Navier-Stokes equation.40 The component of the fluid is water with a kinetic viscosity of v = 1 × 10−6 m2/s at room temperature. The concentrations of the two different fluids to be mixed were set as C = 0 mol/m3 and C = 100 mol/m3 at inlet 1 and inlet 2, respectively, while the diffusion coefficient of the solute in water was D = 2.3 × 10−9 m2/s.41 The channel design matched the fabricated mixer, as shown in Fig. 1. The mixer had a fixed input area of 200 μm × 200 μm. The units were 600 μm apart, and the arc radius of the mixer was 1000 μm, with an effective channel length of ∼785 μm. The concentration of the input specimen was 100 mol/m3, and the liquid medium was water. There were two inputs, which would sustain a laminar inflow, with a volumetric flow rate of 100 μl/min, and one outlet. The result of mixing different concentrations is shown in Fig. 3(a). It was evident that three mixer units were necessary to achieve full mixing. In the inset of Fig. 3(a), the first three units of the mixer are enlarged to show the concentration flow profile within the mixer. After the third unit, the flow concentration was almost unchanged throughout the mixer. Fig. 3(b) further shows the flow concentration profile after each unit (U1, U2, and U3), revealing the remarkable mixing efficiency within the first three units.


A "twisted" microfluidic mixer suitable for a wide range of flow rate applications.

Sivashankar S, Agambayev S, Mashraei Y, Li EQ, Thoroddsen ST, Salama KN - Biomicrofluidics (2016)

Simulation results (a) design and concentration profile of the 3D mixer, with an enlarged view of the first 3 units showing the concentration profiles varying in the units (b) flow concentration profiles at cross sections for the first 3 units.
© Copyright Policy - ccc - open
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4930447&req=5

f3: Simulation results (a) design and concentration profile of the 3D mixer, with an enlarged view of the first 3 units showing the concentration profiles varying in the units (b) flow concentration profiles at cross sections for the first 3 units.
Mentions: Simulations were performed with the COMSOL Multiphysics commercial software (COMSOL 5.2) in order to quantify the mixing performance of the micromixer. The mixing profile within the unit was investigated using 3D models, as depicted in Fig. 1. In the numerical simulation models, the type of the fluid used was an incompressible Newton fluid governed by the Navier-Stokes equation.40 The component of the fluid is water with a kinetic viscosity of v = 1 × 10−6 m2/s at room temperature. The concentrations of the two different fluids to be mixed were set as C = 0 mol/m3 and C = 100 mol/m3 at inlet 1 and inlet 2, respectively, while the diffusion coefficient of the solute in water was D = 2.3 × 10−9 m2/s.41 The channel design matched the fabricated mixer, as shown in Fig. 1. The mixer had a fixed input area of 200 μm × 200 μm. The units were 600 μm apart, and the arc radius of the mixer was 1000 μm, with an effective channel length of ∼785 μm. The concentration of the input specimen was 100 mol/m3, and the liquid medium was water. There were two inputs, which would sustain a laminar inflow, with a volumetric flow rate of 100 μl/min, and one outlet. The result of mixing different concentrations is shown in Fig. 3(a). It was evident that three mixer units were necessary to achieve full mixing. In the inset of Fig. 3(a), the first three units of the mixer are enlarged to show the concentration flow profile within the mixer. After the third unit, the flow concentration was almost unchanged throughout the mixer. Fig. 3(b) further shows the flow concentration profile after each unit (U1, U2, and U3), revealing the remarkable mixing efficiency within the first three units.

Bottom Line: The efficiency of mixing was calculated within the channel by acquiring intensities using ImageJ software.Results suggested that efficient mixing can be obtained when more than 3 units were consecutively placed.The geometry of the device, which has a length of 30 mm, enables the device to be integrated with micro total analysis systems and other lab-on-chip devices.

View Article: PubMed Central - PubMed

Affiliation: Computer, Electrical and Mathematical Science and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST) , Thuwal, Saudi Arabia.

ABSTRACT
This paper proposes a new "twisted" 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamination of mixer units provides the splitting and recombination mechanism when the quadrant of circles is arranged in a two-layered serial arrangement of mixing units. The overall 3D path of the microchannel introduces the advection. An experimental investigation using chemical solutions revealed that these novel 3D passive microfluidic mixers were stable and could be operated at a wide range of flow rates. This micromixer finds application in the manipulation of tiny volumes of liquids that are crucial in diagnostics. The mixing performance was evaluated by dye visualization, and using a pH test that determined the chemical reaction of the solutions. A comparison of the tornado-mixer with this twisted micromixer was made to evaluate the efficiency of mixing. The efficiency of mixing was calculated within the channel by acquiring intensities using ImageJ software. Results suggested that efficient mixing can be obtained when more than 3 units were consecutively placed. The geometry of the device, which has a length of 30 mm, enables the device to be integrated with micro total analysis systems and other lab-on-chip devices.

No MeSH data available.


Related in: MedlinePlus