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Spatial selective manipulation of microbubbles by tunable surface acoustic waves.

Zhou W, Niu L, Cai F, Li F, Wang C, Huang X, Wang J, Wu J, Meng L, Zheng H - Biomicrofluidics (2016)

Bottom Line: The displacement of MBs has a linear relationship with the frequency shift.In addition, the MBs can be controlled in a two-dimensional plane by combining variations of the frequency and the relative phase of the excitation signal applied on the SFITs simultaneously.This technology may open up the possibility of selectively and flexibly manipulating MBs using a simple one-dimensional device.

View Article: PubMed Central - PubMed

Affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen 518055, People's Republic of China.

ABSTRACT
A microfluidic device based on a pair of slant-finger interdigital transducers (SFITs) is developed to achieve a selective and flexible manipulation of microbubbles (MBs) by surface acoustic waves (SAWs). The resonance frequency of SAWs generated by the SFITs depends on the location of its parallel pathway; the particles at different locations of the SAWs' pathway can be controlled selectively by choosing the frequency of the excitation signal applied on the SFITs. By adjusting the input signal continuously, MBs can be transported along the acoustic aperture precisely. The displacement of MBs has a linear relationship with the frequency shift. The resolution of transportation is 15.19 ± 2.65 μm when the shift of input signal frequency is at a step of 10 kHz. In addition, the MBs can be controlled in a two-dimensional plane by combining variations of the frequency and the relative phase of the excitation signal applied on the SFITs simultaneously. This technology may open up the possibility of selectively and flexibly manipulating MBs using a simple one-dimensional device.

No MeSH data available.


Related in: MedlinePlus

(a) The movement of MBs along the acoustic aperture by changing the input frequency from 19.17 MHz to 19.12 MHz at a step of 10 kHz. (b) The relationship between the displacement of the MBs and the shift of the frequency. (Multimedia view) [URL: http://dx.doi.org/10.1063/1.4954934.1]10.1063/1.4954934.1
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f3: (a) The movement of MBs along the acoustic aperture by changing the input frequency from 19.17 MHz to 19.12 MHz at a step of 10 kHz. (b) The relationship between the displacement of the MBs and the shift of the frequency. (Multimedia view) [URL: http://dx.doi.org/10.1063/1.4954934.1]10.1063/1.4954934.1

Mentions: To investigate the frequency-shift effects in manipulating MBs in the direction perpendicular to acoustic propagation, the input signal frequency was changed continuously to excite the resonance of the SFITs at different locations. Initially, MBs were injected into a microchannel by a micro-syringe pump. The SFITs were connected to a power amplifier which amplifies a continuous sine-wave signal of 19.17 MHz. The MBs moved immediately and aggregated into clusters at the pressure nodes. When the input frequency was decreased at a step of 10 kHz, MBs moved toward the negative Y direction continuously. Fig. 3(a) (Multimedia view) shows the movement of the MBs in Y direction when changing the input signal frequency from 19.17 MHz to 19.12 MHz at a step of 10 kHz. The velocity of movement was nearly the same at each transportation, with the speed of 50 μm/s.


Spatial selective manipulation of microbubbles by tunable surface acoustic waves.

Zhou W, Niu L, Cai F, Li F, Wang C, Huang X, Wang J, Wu J, Meng L, Zheng H - Biomicrofluidics (2016)

(a) The movement of MBs along the acoustic aperture by changing the input frequency from 19.17 MHz to 19.12 MHz at a step of 10 kHz. (b) The relationship between the displacement of the MBs and the shift of the frequency. (Multimedia view) [URL: http://dx.doi.org/10.1063/1.4954934.1]10.1063/1.4954934.1
© Copyright Policy - ccc - open
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4930446&req=5

f3: (a) The movement of MBs along the acoustic aperture by changing the input frequency from 19.17 MHz to 19.12 MHz at a step of 10 kHz. (b) The relationship between the displacement of the MBs and the shift of the frequency. (Multimedia view) [URL: http://dx.doi.org/10.1063/1.4954934.1]10.1063/1.4954934.1
Mentions: To investigate the frequency-shift effects in manipulating MBs in the direction perpendicular to acoustic propagation, the input signal frequency was changed continuously to excite the resonance of the SFITs at different locations. Initially, MBs were injected into a microchannel by a micro-syringe pump. The SFITs were connected to a power amplifier which amplifies a continuous sine-wave signal of 19.17 MHz. The MBs moved immediately and aggregated into clusters at the pressure nodes. When the input frequency was decreased at a step of 10 kHz, MBs moved toward the negative Y direction continuously. Fig. 3(a) (Multimedia view) shows the movement of the MBs in Y direction when changing the input signal frequency from 19.17 MHz to 19.12 MHz at a step of 10 kHz. The velocity of movement was nearly the same at each transportation, with the speed of 50 μm/s.

Bottom Line: The displacement of MBs has a linear relationship with the frequency shift.In addition, the MBs can be controlled in a two-dimensional plane by combining variations of the frequency and the relative phase of the excitation signal applied on the SFITs simultaneously.This technology may open up the possibility of selectively and flexibly manipulating MBs using a simple one-dimensional device.

View Article: PubMed Central - PubMed

Affiliation: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen 518055, People's Republic of China.

ABSTRACT
A microfluidic device based on a pair of slant-finger interdigital transducers (SFITs) is developed to achieve a selective and flexible manipulation of microbubbles (MBs) by surface acoustic waves (SAWs). The resonance frequency of SAWs generated by the SFITs depends on the location of its parallel pathway; the particles at different locations of the SAWs' pathway can be controlled selectively by choosing the frequency of the excitation signal applied on the SFITs. By adjusting the input signal continuously, MBs can be transported along the acoustic aperture precisely. The displacement of MBs has a linear relationship with the frequency shift. The resolution of transportation is 15.19 ± 2.65 μm when the shift of input signal frequency is at a step of 10 kHz. In addition, the MBs can be controlled in a two-dimensional plane by combining variations of the frequency and the relative phase of the excitation signal applied on the SFITs simultaneously. This technology may open up the possibility of selectively and flexibly manipulating MBs using a simple one-dimensional device.

No MeSH data available.


Related in: MedlinePlus