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A systematic review and meta-analysis of the application of platelet rich plasma in sports medicine.

Gholami M, Ravaghi H, Salehi M, Yekta AA, Doaee S, Jaafaripooyan E - Electron Physician (2016)

Bottom Line: A systematic review of the literature and meta-analysis of results were undertaken.The analysis of the results of pain scores and physical activity/functions did not show any superiority for PRP as opposed to the other options.Well-designed RCTs are needed to support the findings.

View Article: PubMed Central - PubMed

Affiliation: MS in Health Technology Assessment, Department of Health Sciences Educational Development, School of Public Health, Tehran University of Medical Science, Tehran, Iran.

ABSTRACT

Introduction: In recent years, platelet rich plasma (PRP) has been receiving increasing attention for the treatment of soft tissue injuries. These numerous applications have raised a great deal of questions and debate about the effectiveness of this method. This study aimed to determine the efficacy of PRP in improving sports injuries and subsequently throw some light on these controversies.

Methods: A systematic review of the literature and meta-analysis of results were undertaken. All related databases, such as PubMed, Cochrane Database of Systematic Reviews, DARE, and EMBASE, were searched on the use of PRP on athletes and in sports medicine. The search was conducted from June 2013 to February 2014.

Results: Our search retrieved 905 studies, of which 13 randomized control trials (RCT) met our inclusion criteria for systematic review and meta-analysis. All articles were appraised by Critical Appraisal Skills Program (CASP) checklist for RCT studies. The analysis of the results of pain scores and physical activity/functions did not show any superiority for PRP as opposed to the other options.

Conclusions: The meta-analysis showed no more effectiveness for PRP application in sports-related injuries in terms of physical function improvement and pain relief. Therefore, the extensive use of PRP for such injuries should be limited. Well-designed RCTs are needed to support the findings.

No MeSH data available.


Related in: MedlinePlus

Funnel Plot of studies that evaluated the effect of PRP on pain reduction
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Related In: Results  -  Collection

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f2-epj-08-2325: Funnel Plot of studies that evaluated the effect of PRP on pain reduction

Mentions: Publication bias was examined by the Begg Test and Egger regression. There was no considerable publication bias (Figure 2).


A systematic review and meta-analysis of the application of platelet rich plasma in sports medicine.

Gholami M, Ravaghi H, Salehi M, Yekta AA, Doaee S, Jaafaripooyan E - Electron Physician (2016)

Funnel Plot of studies that evaluated the effect of PRP on pain reduction
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4930250&req=5

f2-epj-08-2325: Funnel Plot of studies that evaluated the effect of PRP on pain reduction
Mentions: Publication bias was examined by the Begg Test and Egger regression. There was no considerable publication bias (Figure 2).

Bottom Line: A systematic review of the literature and meta-analysis of results were undertaken.The analysis of the results of pain scores and physical activity/functions did not show any superiority for PRP as opposed to the other options.Well-designed RCTs are needed to support the findings.

View Article: PubMed Central - PubMed

Affiliation: MS in Health Technology Assessment, Department of Health Sciences Educational Development, School of Public Health, Tehran University of Medical Science, Tehran, Iran.

ABSTRACT

Introduction: In recent years, platelet rich plasma (PRP) has been receiving increasing attention for the treatment of soft tissue injuries. These numerous applications have raised a great deal of questions and debate about the effectiveness of this method. This study aimed to determine the efficacy of PRP in improving sports injuries and subsequently throw some light on these controversies.

Methods: A systematic review of the literature and meta-analysis of results were undertaken. All related databases, such as PubMed, Cochrane Database of Systematic Reviews, DARE, and EMBASE, were searched on the use of PRP on athletes and in sports medicine. The search was conducted from June 2013 to February 2014.

Results: Our search retrieved 905 studies, of which 13 randomized control trials (RCT) met our inclusion criteria for systematic review and meta-analysis. All articles were appraised by Critical Appraisal Skills Program (CASP) checklist for RCT studies. The analysis of the results of pain scores and physical activity/functions did not show any superiority for PRP as opposed to the other options.

Conclusions: The meta-analysis showed no more effectiveness for PRP application in sports-related injuries in terms of physical function improvement and pain relief. Therefore, the extensive use of PRP for such injuries should be limited. Well-designed RCTs are needed to support the findings.

No MeSH data available.


Related in: MedlinePlus