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Cognitive training modifies disease symptoms in a mouse model of Huntington's disease.

Yhnell E, Lelos MJ, Dunnett SB, Brooks SP - Exp. Neurol. (2016)

Bottom Line: All groups were then tested in an operant task of attention at 12months of age.Relative to the group that received comparable training in a non-attentional task, both wildtype and Hdh(Q111) mice that received attentional training demonstrated superior accuracy in the task and made fewer 'time out' errors.Attentional cognitive training also improved motor performance in Hdh(Q111) mice, thus leading to the conclusion that cognitive training can improve disease symptoms in a mouse model of HD.

View Article: PubMed Central - PubMed

Affiliation: The Brain Repair Group, Cardiff University School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, Wales CF10 3AX, United Kingdom. Electronic address: YhnellE@cardiff.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Comparison of attentional and non-attentional cognitive training on subsequent 5-CSRTT performance. A. Total trials started demonstrated less trials were made at the short stimulus length and by HdhQ111/+ animals in comparison to wildtype animals. B. Accuracy in responding was improved in animals that had received attentional cognitive training in comparison to animals that had received cognitive training in a non-attentional task. C. Response time was decreased in HdhQ111/+ animals but no effect of cognitive training regime was seen. D. Time out responses made. Despite a trend for HdhQ111/+ animals that had received attentional cognitive training to make fewer time outs than HdhQ111/+ animals that had received comparable non-attentional cognitive training, this interaction failed to meet significance. The data represents a total of 28 animals (Group 1 contained 14 animals, 7 of which were HdhQ111/+ and Group 2 contained 14 animals, 6 of which were HdhQ111/+). Error bars represent ± standard error of the mean.
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f0020: Comparison of attentional and non-attentional cognitive training on subsequent 5-CSRTT performance. A. Total trials started demonstrated less trials were made at the short stimulus length and by HdhQ111/+ animals in comparison to wildtype animals. B. Accuracy in responding was improved in animals that had received attentional cognitive training in comparison to animals that had received cognitive training in a non-attentional task. C. Response time was decreased in HdhQ111/+ animals but no effect of cognitive training regime was seen. D. Time out responses made. Despite a trend for HdhQ111/+ animals that had received attentional cognitive training to make fewer time outs than HdhQ111/+ animals that had received comparable non-attentional cognitive training, this interaction failed to meet significance. The data represents a total of 28 animals (Group 1 contained 14 animals, 7 of which were HdhQ111/+ and Group 2 contained 14 animals, 6 of which were HdhQ111/+). Error bars represent ± standard error of the mean.

Mentions: Animals that received cognitive training in a non-attentional operant task (Group 2, Table 1) were able to initiate a similar number of trials in the 5-CSRTT as animals that had received attentional cognitive training in the 5-CSRTT (Fig. 4A, Group: F1,24 = 3.05, p = n.s.). Overall, HdhQ111/+ animals initiated fewer trials in the 5-CSRTT than wildtype animals (Fig. 4A, Genotype: F1,24 = 40.94, p < 0.001) and fewer trials were initiated for all mice at the shorter 0.5 second stimulus length in comparison to the 2 second stimulus length (Fig. 4A, Stimulus length: F1,24 = 21.98, p < 0.001).


Cognitive training modifies disease symptoms in a mouse model of Huntington's disease.

Yhnell E, Lelos MJ, Dunnett SB, Brooks SP - Exp. Neurol. (2016)

Comparison of attentional and non-attentional cognitive training on subsequent 5-CSRTT performance. A. Total trials started demonstrated less trials were made at the short stimulus length and by HdhQ111/+ animals in comparison to wildtype animals. B. Accuracy in responding was improved in animals that had received attentional cognitive training in comparison to animals that had received cognitive training in a non-attentional task. C. Response time was decreased in HdhQ111/+ animals but no effect of cognitive training regime was seen. D. Time out responses made. Despite a trend for HdhQ111/+ animals that had received attentional cognitive training to make fewer time outs than HdhQ111/+ animals that had received comparable non-attentional cognitive training, this interaction failed to meet significance. The data represents a total of 28 animals (Group 1 contained 14 animals, 7 of which were HdhQ111/+ and Group 2 contained 14 animals, 6 of which were HdhQ111/+). Error bars represent ± standard error of the mean.
© Copyright Policy - CC BY
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4920669&req=5

f0020: Comparison of attentional and non-attentional cognitive training on subsequent 5-CSRTT performance. A. Total trials started demonstrated less trials were made at the short stimulus length and by HdhQ111/+ animals in comparison to wildtype animals. B. Accuracy in responding was improved in animals that had received attentional cognitive training in comparison to animals that had received cognitive training in a non-attentional task. C. Response time was decreased in HdhQ111/+ animals but no effect of cognitive training regime was seen. D. Time out responses made. Despite a trend for HdhQ111/+ animals that had received attentional cognitive training to make fewer time outs than HdhQ111/+ animals that had received comparable non-attentional cognitive training, this interaction failed to meet significance. The data represents a total of 28 animals (Group 1 contained 14 animals, 7 of which were HdhQ111/+ and Group 2 contained 14 animals, 6 of which were HdhQ111/+). Error bars represent ± standard error of the mean.
Mentions: Animals that received cognitive training in a non-attentional operant task (Group 2, Table 1) were able to initiate a similar number of trials in the 5-CSRTT as animals that had received attentional cognitive training in the 5-CSRTT (Fig. 4A, Group: F1,24 = 3.05, p = n.s.). Overall, HdhQ111/+ animals initiated fewer trials in the 5-CSRTT than wildtype animals (Fig. 4A, Genotype: F1,24 = 40.94, p < 0.001) and fewer trials were initiated for all mice at the shorter 0.5 second stimulus length in comparison to the 2 second stimulus length (Fig. 4A, Stimulus length: F1,24 = 21.98, p < 0.001).

Bottom Line: All groups were then tested in an operant task of attention at 12months of age.Relative to the group that received comparable training in a non-attentional task, both wildtype and Hdh(Q111) mice that received attentional training demonstrated superior accuracy in the task and made fewer 'time out' errors.Attentional cognitive training also improved motor performance in Hdh(Q111) mice, thus leading to the conclusion that cognitive training can improve disease symptoms in a mouse model of HD.

View Article: PubMed Central - PubMed

Affiliation: The Brain Repair Group, Cardiff University School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, Wales CF10 3AX, United Kingdom. Electronic address: YhnellE@cardiff.ac.uk.

No MeSH data available.


Related in: MedlinePlus