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Cognitive training modifies disease symptoms in a mouse model of Huntington's disease.

Yhnell E, Lelos MJ, Dunnett SB, Brooks SP - Exp. Neurol. (2016)

Bottom Line: All groups were then tested in an operant task of attention at 12months of age.Relative to the group that received comparable training in a non-attentional task, both wildtype and Hdh(Q111) mice that received attentional training demonstrated superior accuracy in the task and made fewer 'time out' errors.Attentional cognitive training also improved motor performance in Hdh(Q111) mice, thus leading to the conclusion that cognitive training can improve disease symptoms in a mouse model of HD.

View Article: PubMed Central - PubMed

Affiliation: The Brain Repair Group, Cardiff University School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, Wales CF10 3AX, United Kingdom. Electronic address: YhnellE@cardiff.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Attentional cognitive training improves subsequent performance in the 5-CSRTT. A. Total trials started, demonstrated that attentional cognitive training increases the number of trials started. B. Accuracy in responding was higher in the groups that had received previous training. C. Response time was faster in the groups that had received attentional cognitive training and significantly improved in HdhQ111/+ animals that had received attentional cognitive training. D. Time outs made as a percentage of total responses were decreased in the group that received attentional cognitive training and significantly decreased in HdhQ111/+ animals that had received attentional cognitive training. Data represents a total of 27 animals (Group 1 n = 14 (7 WT and 7 HdhQ111/+) and group 3, n = 14 (7 WT and 6 HdhQ111/+)). Data is shown for the final 5 days of testing at the 2 second and 0.5 second stimulus lengths. Error bars represent ± standard error of the mean. Significant results are indicated, Grp = Group, Geno = Genotype, S.L. = stimulus length. * p < 0.05, ** p < 0.01, *** p < 0.001.
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f0015: Attentional cognitive training improves subsequent performance in the 5-CSRTT. A. Total trials started, demonstrated that attentional cognitive training increases the number of trials started. B. Accuracy in responding was higher in the groups that had received previous training. C. Response time was faster in the groups that had received attentional cognitive training and significantly improved in HdhQ111/+ animals that had received attentional cognitive training. D. Time outs made as a percentage of total responses were decreased in the group that received attentional cognitive training and significantly decreased in HdhQ111/+ animals that had received attentional cognitive training. Data represents a total of 27 animals (Group 1 n = 14 (7 WT and 7 HdhQ111/+) and group 3, n = 14 (7 WT and 6 HdhQ111/+)). Data is shown for the final 5 days of testing at the 2 second and 0.5 second stimulus lengths. Error bars represent ± standard error of the mean. Significant results are indicated, Grp = Group, Geno = Genotype, S.L. = stimulus length. * p < 0.05, ** p < 0.01, *** p < 0.001.

Mentions: Mice in Group 1 that received attentional cognitive training on the 5-CSRTT task at a young age initiated significantly more trials in the 5-CSRTT in comparison to Group 3 animals that had not received prior cognitive training in the task (Group: F1,23 = 21.83, p < 0.001), as seen in Fig. 3A. HdhQ111/+ animals overall initiated fewer trials than wildtype animals (Fig. 3A, Genotype: F1,23 = 46.58, p < 0.001). Moreover, fewer trials were initiated when the shorter 0.5 second stimulus length was used, in comparison to the longer 2 second stimulus length (Fig. 3A, Stimulus length; F1,23 = 27.75, p < 0.001).


Cognitive training modifies disease symptoms in a mouse model of Huntington's disease.

Yhnell E, Lelos MJ, Dunnett SB, Brooks SP - Exp. Neurol. (2016)

Attentional cognitive training improves subsequent performance in the 5-CSRTT. A. Total trials started, demonstrated that attentional cognitive training increases the number of trials started. B. Accuracy in responding was higher in the groups that had received previous training. C. Response time was faster in the groups that had received attentional cognitive training and significantly improved in HdhQ111/+ animals that had received attentional cognitive training. D. Time outs made as a percentage of total responses were decreased in the group that received attentional cognitive training and significantly decreased in HdhQ111/+ animals that had received attentional cognitive training. Data represents a total of 27 animals (Group 1 n = 14 (7 WT and 7 HdhQ111/+) and group 3, n = 14 (7 WT and 6 HdhQ111/+)). Data is shown for the final 5 days of testing at the 2 second and 0.5 second stimulus lengths. Error bars represent ± standard error of the mean. Significant results are indicated, Grp = Group, Geno = Genotype, S.L. = stimulus length. * p < 0.05, ** p < 0.01, *** p < 0.001.
© Copyright Policy - CC BY
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4920669&req=5

f0015: Attentional cognitive training improves subsequent performance in the 5-CSRTT. A. Total trials started, demonstrated that attentional cognitive training increases the number of trials started. B. Accuracy in responding was higher in the groups that had received previous training. C. Response time was faster in the groups that had received attentional cognitive training and significantly improved in HdhQ111/+ animals that had received attentional cognitive training. D. Time outs made as a percentage of total responses were decreased in the group that received attentional cognitive training and significantly decreased in HdhQ111/+ animals that had received attentional cognitive training. Data represents a total of 27 animals (Group 1 n = 14 (7 WT and 7 HdhQ111/+) and group 3, n = 14 (7 WT and 6 HdhQ111/+)). Data is shown for the final 5 days of testing at the 2 second and 0.5 second stimulus lengths. Error bars represent ± standard error of the mean. Significant results are indicated, Grp = Group, Geno = Genotype, S.L. = stimulus length. * p < 0.05, ** p < 0.01, *** p < 0.001.
Mentions: Mice in Group 1 that received attentional cognitive training on the 5-CSRTT task at a young age initiated significantly more trials in the 5-CSRTT in comparison to Group 3 animals that had not received prior cognitive training in the task (Group: F1,23 = 21.83, p < 0.001), as seen in Fig. 3A. HdhQ111/+ animals overall initiated fewer trials than wildtype animals (Fig. 3A, Genotype: F1,23 = 46.58, p < 0.001). Moreover, fewer trials were initiated when the shorter 0.5 second stimulus length was used, in comparison to the longer 2 second stimulus length (Fig. 3A, Stimulus length; F1,23 = 27.75, p < 0.001).

Bottom Line: All groups were then tested in an operant task of attention at 12months of age.Relative to the group that received comparable training in a non-attentional task, both wildtype and Hdh(Q111) mice that received attentional training demonstrated superior accuracy in the task and made fewer 'time out' errors.Attentional cognitive training also improved motor performance in Hdh(Q111) mice, thus leading to the conclusion that cognitive training can improve disease symptoms in a mouse model of HD.

View Article: PubMed Central - PubMed

Affiliation: The Brain Repair Group, Cardiff University School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, Wales CF10 3AX, United Kingdom. Electronic address: YhnellE@cardiff.ac.uk.

No MeSH data available.


Related in: MedlinePlus