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The influence of distal colon irritation on the changes of cystometry parameters to esophagus and colon distentions.

Kaddumi EG - Int Braz J Urol (2016 May-Jun)

Bottom Line: In the contrary, 3mL DCD significantly increased the P-amplitude by increasing the MP and lost that effect following the DCI.However, DCI significantly decreased the PT, also, the abd-vagus and 3mL DCD significantly decreased the PT.The results of this study indicate that chemical irritation of colon complicates the effects of mechanical irritation of esophagus and colon on urinary bladder function.

View Article: PubMed Central - PubMed

Affiliation: Department of Basic Medical Sciences, Collage of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.

ABSTRACT
The co-occurrence of multiple pathologies in the pelvic viscera in the same patient, such as, irritable bowel syndrome and interstitial cystitis, indicates the complexity of viscero-visceral interactions and the necessity to study these interactions under multiple pathological conditions. In the present study, the effect of distal colon irritation (DCI) on the urinary bladder interaction with distal esophagus distention (DED), distal colon distention (DCD), and electrical stimulation of the abdominal branches of vagus nerve (abd-vagus) were investigated using cystometry parameters. The DCI significantly decreased the intercontraction time (ICT) by decreasing the storage time (ST); nonetheless, DED and Abd-vagus were still able to significantly decrease the ICT and ST following DCI. However, DCD had no effect on ICT following the DCI. The DCI, also, significantly decreased the Intravesical pressure amplitude (P-amplitude) by increasing the resting pressure (RP). Although DED has no effect on the P-amplitude, both in the intact and the irritated animals, the abd-vagus significantly increased the P-amplitude following DCI by increasing the maximum pressure (MP). In the contrary, 3mL DCD significantly increased the P-amplitude by increasing the MP and lost that effect following the DCI. Concerning the pressure threshold (PT), none of the stimuli had any significant changes in the intact animals. However, DCI significantly decreased the PT, also, the abd-vagus and 3mL DCD significantly decreased the PT. The results of this study indicate that chemical irritation of colon complicates the effects of mechanical irritation of esophagus and colon on urinary bladder function.

No MeSH data available.


Related in: MedlinePlus

Effect of different visceral stimuli on the intercontraction time (ICT) in the intact and the irritated animals. In the intact animals, distal esophagus distention and electrical stimulation of abdominal branches of vagus nerve significantly (P ˂ 0.01 and P ˂ 0.05 respectively) decreased the ICT (data published (3)), however, distal colon distention with 3 ml significantly (P ˂ 0.04) increased the ICT (under publication). In irritated animals, chemical irritation of the distal colon significantly (P ˂ 0.001) decreased the ICT; distal esophagus distention and vagal stimulation significantly (P ˂ 0.03) decreased ICT; distal colon distention had no significant effect. Vertical bars represent standard error of the mean.
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f01: Effect of different visceral stimuli on the intercontraction time (ICT) in the intact and the irritated animals. In the intact animals, distal esophagus distention and electrical stimulation of abdominal branches of vagus nerve significantly (P ˂ 0.01 and P ˂ 0.05 respectively) decreased the ICT (data published (3)), however, distal colon distention with 3 ml significantly (P ˂ 0.04) increased the ICT (under publication). In irritated animals, chemical irritation of the distal colon significantly (P ˂ 0.001) decreased the ICT; distal esophagus distention and vagal stimulation significantly (P ˂ 0.03) decreased ICT; distal colon distention had no significant effect. Vertical bars represent standard error of the mean.

Mentions: Distal colon irritation significantly increased the ICT. In addition, DCI significantly increased the ST, however, there was no significant changes to the VT following distal colon irritation. Compared to intact animals (3), in the irritated animals, distal esophagus distention and electrical stimulation of the abdominal branches of the vagus nerve were still able to significantly decrease the ICT and ST of the micturition cycles without any significant effect on the VT. On the other hand, following distal colon irritation, all three distention increments (1mL, 2mL, and 3mL) of distal colon had no significant effect on the ICT, ST, or VT, and so, all significant effects of distal colon distention on these parameters in the intact animals (under publication) disappeared following distal colon irritation. The effect of esophagus, vagal, and distal colon stimuli on the ICT are presented in Figure-1. All data for VT and ST of the micturition cycles are presented in Table-1.


The influence of distal colon irritation on the changes of cystometry parameters to esophagus and colon distentions.

Kaddumi EG - Int Braz J Urol (2016 May-Jun)

Effect of different visceral stimuli on the intercontraction time (ICT) in the intact and the irritated animals. In the intact animals, distal esophagus distention and electrical stimulation of abdominal branches of vagus nerve significantly (P ˂ 0.01 and P ˂ 0.05 respectively) decreased the ICT (data published (3)), however, distal colon distention with 3 ml significantly (P ˂ 0.04) increased the ICT (under publication). In irritated animals, chemical irritation of the distal colon significantly (P ˂ 0.001) decreased the ICT; distal esophagus distention and vagal stimulation significantly (P ˂ 0.03) decreased ICT; distal colon distention had no significant effect. Vertical bars represent standard error of the mean.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4920580&req=5

f01: Effect of different visceral stimuli on the intercontraction time (ICT) in the intact and the irritated animals. In the intact animals, distal esophagus distention and electrical stimulation of abdominal branches of vagus nerve significantly (P ˂ 0.01 and P ˂ 0.05 respectively) decreased the ICT (data published (3)), however, distal colon distention with 3 ml significantly (P ˂ 0.04) increased the ICT (under publication). In irritated animals, chemical irritation of the distal colon significantly (P ˂ 0.001) decreased the ICT; distal esophagus distention and vagal stimulation significantly (P ˂ 0.03) decreased ICT; distal colon distention had no significant effect. Vertical bars represent standard error of the mean.
Mentions: Distal colon irritation significantly increased the ICT. In addition, DCI significantly increased the ST, however, there was no significant changes to the VT following distal colon irritation. Compared to intact animals (3), in the irritated animals, distal esophagus distention and electrical stimulation of the abdominal branches of the vagus nerve were still able to significantly decrease the ICT and ST of the micturition cycles without any significant effect on the VT. On the other hand, following distal colon irritation, all three distention increments (1mL, 2mL, and 3mL) of distal colon had no significant effect on the ICT, ST, or VT, and so, all significant effects of distal colon distention on these parameters in the intact animals (under publication) disappeared following distal colon irritation. The effect of esophagus, vagal, and distal colon stimuli on the ICT are presented in Figure-1. All data for VT and ST of the micturition cycles are presented in Table-1.

Bottom Line: In the contrary, 3mL DCD significantly increased the P-amplitude by increasing the MP and lost that effect following the DCI.However, DCI significantly decreased the PT, also, the abd-vagus and 3mL DCD significantly decreased the PT.The results of this study indicate that chemical irritation of colon complicates the effects of mechanical irritation of esophagus and colon on urinary bladder function.

View Article: PubMed Central - PubMed

Affiliation: Department of Basic Medical Sciences, Collage of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.

ABSTRACT
The co-occurrence of multiple pathologies in the pelvic viscera in the same patient, such as, irritable bowel syndrome and interstitial cystitis, indicates the complexity of viscero-visceral interactions and the necessity to study these interactions under multiple pathological conditions. In the present study, the effect of distal colon irritation (DCI) on the urinary bladder interaction with distal esophagus distention (DED), distal colon distention (DCD), and electrical stimulation of the abdominal branches of vagus nerve (abd-vagus) were investigated using cystometry parameters. The DCI significantly decreased the intercontraction time (ICT) by decreasing the storage time (ST); nonetheless, DED and Abd-vagus were still able to significantly decrease the ICT and ST following DCI. However, DCD had no effect on ICT following the DCI. The DCI, also, significantly decreased the Intravesical pressure amplitude (P-amplitude) by increasing the resting pressure (RP). Although DED has no effect on the P-amplitude, both in the intact and the irritated animals, the abd-vagus significantly increased the P-amplitude following DCI by increasing the maximum pressure (MP). In the contrary, 3mL DCD significantly increased the P-amplitude by increasing the MP and lost that effect following the DCI. Concerning the pressure threshold (PT), none of the stimuli had any significant changes in the intact animals. However, DCI significantly decreased the PT, also, the abd-vagus and 3mL DCD significantly decreased the PT. The results of this study indicate that chemical irritation of colon complicates the effects of mechanical irritation of esophagus and colon on urinary bladder function.

No MeSH data available.


Related in: MedlinePlus