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The role of angiogenesis in implant dentistry part II: The effect of bone-grafting and barrier membrane materials on angiogenesis.

Saghiri MA, Asatourian A, Garcia-Godoy F, Sheibani N - Med Oral Patol Oral Cir Bucal (2016)

Bottom Line: Of the 5,622 articles identified in our initial search results, only 33 met the inclusion criteria set for this review.Among bone substitute materials the autogenous bone-grafts, and among the barrier membranes the collagenous membranes, had the highest angiogenic potentials.Other bone-grafting materials or membranes were mostly used with pro-angiogenic factors to enhance their angiogenic properties.

View Article: PubMed Central - PubMed

Affiliation: Departments of Ophthalmology &, Visual Sciences and Biomedical Engineering, University of Wisconsin School of Medicine, and Public health, Madison, WI, USA, Saghiri@wisc.edu.

ABSTRACT

Background: In implant dentistry, bone substitute materials and barrier membranes are used in different treatments including guided bone regeneration (GBR), socket preservation, alveolar ridge augmentation, maxillary sinus elevation, and filling bony defects around the inserted dental implant. One of the most important factors in prognosis of treatments using these materials is the growth of new blood vessels in applied areas. Present review was performed to evaluate the effect of the bone-grafting and barrier membrane materials on angiogenesis events.

Material and methods: An electronic search was performed in PubMed, MEDLINE, and EMBASE databases via OVID using the keywords mentioned in the PubMed and MeSH headings regarding the role of angiogenesis in implant dentistry from January 2000-April 2014.

Results: Of the 5,622 articles identified in our initial search results, only 33 met the inclusion criteria set for this review. Among bone substitute materials the autogenous bone-grafts, and among the barrier membranes the collagenous membranes, had the highest angiogenic potentials. Other bone-grafting materials or membranes were mostly used with pro-angiogenic factors to enhance their angiogenic properties.

Conclusions: Angiogenesis is one of the key factors, which plays a critical role in success rate of GBR technique and is seriously considered in manufacturing bone-grafting and barrier membrane materials. However, there is still lack of clinical and in-vivo studies addressing the effect of angiogenesis in treatments using bone-grafting and barrier membrane materials.

No MeSH data available.


Related in: MedlinePlus

The angiogenic effects of bone-grafting materials in bone regenerative procedure in schematic socket preservation illustration. Upper figure: the procedure of socket preservation using bone substitute material; Middle figure: presents a schematic figure of autogenous bone material including valuable cellular components such as BM-MSCs, osteocytes, and endothelial cells; Bottom figure: presents a schematic figure of allograft, xenograft, or allopalastic materials, which only includes a matrix and incorporated growth factors (pink spots).
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Figure 1: The angiogenic effects of bone-grafting materials in bone regenerative procedure in schematic socket preservation illustration. Upper figure: the procedure of socket preservation using bone substitute material; Middle figure: presents a schematic figure of autogenous bone material including valuable cellular components such as BM-MSCs, osteocytes, and endothelial cells; Bottom figure: presents a schematic figure of allograft, xenograft, or allopalastic materials, which only includes a matrix and incorporated growth factors (pink spots).

Mentions: Larsen et al. reported that the neoangiogenesis at a recipient site is critical for survival of vascularized allogenic bone grafts (Fig. 1). These authors evaluated the effects of VEGF, FGF-2, and the combination of these pro-angiogenic factors as an additive to allogenic bone materials, on the angiogenesis events occurring at grafting site (40). They showed that FGF-2 had superior pro-angiogenic effects in neoangiogenesis process at the recipient site compared with VEGF (40). Moreira et al. indicated that onlay grafts, which included autogenous and allogenic bone grafts in combination with platelet-rich plasma (PRP) as a modifier, promoted the angiogenesis and osteogenesis events in rabbit mandibles (41) ( Table 1 and Table 1continue).


The role of angiogenesis in implant dentistry part II: The effect of bone-grafting and barrier membrane materials on angiogenesis.

Saghiri MA, Asatourian A, Garcia-Godoy F, Sheibani N - Med Oral Patol Oral Cir Bucal (2016)

The angiogenic effects of bone-grafting materials in bone regenerative procedure in schematic socket preservation illustration. Upper figure: the procedure of socket preservation using bone substitute material; Middle figure: presents a schematic figure of autogenous bone material including valuable cellular components such as BM-MSCs, osteocytes, and endothelial cells; Bottom figure: presents a schematic figure of allograft, xenograft, or allopalastic materials, which only includes a matrix and incorporated growth factors (pink spots).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4920468&req=5

Figure 1: The angiogenic effects of bone-grafting materials in bone regenerative procedure in schematic socket preservation illustration. Upper figure: the procedure of socket preservation using bone substitute material; Middle figure: presents a schematic figure of autogenous bone material including valuable cellular components such as BM-MSCs, osteocytes, and endothelial cells; Bottom figure: presents a schematic figure of allograft, xenograft, or allopalastic materials, which only includes a matrix and incorporated growth factors (pink spots).
Mentions: Larsen et al. reported that the neoangiogenesis at a recipient site is critical for survival of vascularized allogenic bone grafts (Fig. 1). These authors evaluated the effects of VEGF, FGF-2, and the combination of these pro-angiogenic factors as an additive to allogenic bone materials, on the angiogenesis events occurring at grafting site (40). They showed that FGF-2 had superior pro-angiogenic effects in neoangiogenesis process at the recipient site compared with VEGF (40). Moreira et al. indicated that onlay grafts, which included autogenous and allogenic bone grafts in combination with platelet-rich plasma (PRP) as a modifier, promoted the angiogenesis and osteogenesis events in rabbit mandibles (41) ( Table 1 and Table 1continue).

Bottom Line: Of the 5,622 articles identified in our initial search results, only 33 met the inclusion criteria set for this review.Among bone substitute materials the autogenous bone-grafts, and among the barrier membranes the collagenous membranes, had the highest angiogenic potentials.Other bone-grafting materials or membranes were mostly used with pro-angiogenic factors to enhance their angiogenic properties.

View Article: PubMed Central - PubMed

Affiliation: Departments of Ophthalmology &, Visual Sciences and Biomedical Engineering, University of Wisconsin School of Medicine, and Public health, Madison, WI, USA, Saghiri@wisc.edu.

ABSTRACT

Background: In implant dentistry, bone substitute materials and barrier membranes are used in different treatments including guided bone regeneration (GBR), socket preservation, alveolar ridge augmentation, maxillary sinus elevation, and filling bony defects around the inserted dental implant. One of the most important factors in prognosis of treatments using these materials is the growth of new blood vessels in applied areas. Present review was performed to evaluate the effect of the bone-grafting and barrier membrane materials on angiogenesis events.

Material and methods: An electronic search was performed in PubMed, MEDLINE, and EMBASE databases via OVID using the keywords mentioned in the PubMed and MeSH headings regarding the role of angiogenesis in implant dentistry from January 2000-April 2014.

Results: Of the 5,622 articles identified in our initial search results, only 33 met the inclusion criteria set for this review. Among bone substitute materials the autogenous bone-grafts, and among the barrier membranes the collagenous membranes, had the highest angiogenic potentials. Other bone-grafting materials or membranes were mostly used with pro-angiogenic factors to enhance their angiogenic properties.

Conclusions: Angiogenesis is one of the key factors, which plays a critical role in success rate of GBR technique and is seriously considered in manufacturing bone-grafting and barrier membrane materials. However, there is still lack of clinical and in-vivo studies addressing the effect of angiogenesis in treatments using bone-grafting and barrier membrane materials.

No MeSH data available.


Related in: MedlinePlus