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Association between susceptible genotypes to periodontitis and clinical outcomes of periodontal regenerative therapy: A systematic review.

Chatzopoulos GS, Koidou VP - Med Oral Patol Oral Cir Bucal (2016)

Bottom Line: Polymorphisms of Interleukin-1 (IL-1) gene were included in all.Within the limits of the present review, no direct conclusion for the effect of a susceptible IL-1 genotype status to the clinical outcome after periodontal regeneration could be drawn.The need of more qualitative studies to explore a possible association emerges.

View Article: PubMed Central - PubMed

Affiliation: Division of Periodontology, Developmental and Surgical Sciences, School of Dentistry, University of Minnesota, 515 Delaware Street SE, Minneapolis, MN 55455, USA chatz005@umn.edu.

ABSTRACT

Background: The aim of this review is to systematically investigate the effect of a susceptible genotype to periodontitis with the clinical outcomes of periodontal regeneration.

Material and methods: Based on a focused question, an electronic search identified 155 unique citations. Three journals (Journal of Periodontology, Journal of Clinical Periodontology and Journal of Periodontal Research), references of relevant studies and review articles were hand-searched. Two independent reviewers implementing eligibility inclusion criteria selected the studies.

Results: Of the 155, four studies fulfilled the inclusion criteria. All studies were published between 2000 and 2004 and the samples' size was 40 to 86 patients. Polymorphisms of Interleukin-1 (IL-1) gene were included in all. Three out of four studies failed to identify an association between susceptible genotypes to periodontitis and clinical outcomes of periodontal regeneration, while one found an association. The heterogeneity and small number of studies included prevented the conduct of a meta-analysis. No studies were identified evaluating the effect of other genotypes and as a result only IL-1 genotype studies were included.

Conclusions: Within the limits of the present review, no direct conclusion for the effect of a susceptible IL-1 genotype status to the clinical outcome after periodontal regeneration could be drawn. The need of more qualitative studies to explore a possible association emerges.

No MeSH data available.


Related in: MedlinePlus

Search and selection results.
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Figure 1: Search and selection results.

Mentions: Initial electronic searches identified 155 publications. After screening of the titles and abstracts independently, 12 (14,17-27) studies were selected for full-text review (Fig. 1). The other 143 publications were excluded due to the irrelevant topic. All identified papers in first selection included at least a title in English. None of the included papers were in a language other than English and thus translation of the abstract or/and the main text was not required for any paper. Inter reviewer agreement at the first phase of selection was very high (k = 0.92). After full-text and citation mining, four articles were identified as determined by the inclusion and exclusion criteria (k=0.98). Of the four articles, three (25-27) were initially identified by electronic search, while the other one (28) by citation mining.


Association between susceptible genotypes to periodontitis and clinical outcomes of periodontal regenerative therapy: A systematic review.

Chatzopoulos GS, Koidou VP - Med Oral Patol Oral Cir Bucal (2016)

Search and selection results.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4920459&req=5

Figure 1: Search and selection results.
Mentions: Initial electronic searches identified 155 publications. After screening of the titles and abstracts independently, 12 (14,17-27) studies were selected for full-text review (Fig. 1). The other 143 publications were excluded due to the irrelevant topic. All identified papers in first selection included at least a title in English. None of the included papers were in a language other than English and thus translation of the abstract or/and the main text was not required for any paper. Inter reviewer agreement at the first phase of selection was very high (k = 0.92). After full-text and citation mining, four articles were identified as determined by the inclusion and exclusion criteria (k=0.98). Of the four articles, three (25-27) were initially identified by electronic search, while the other one (28) by citation mining.

Bottom Line: Polymorphisms of Interleukin-1 (IL-1) gene were included in all.Within the limits of the present review, no direct conclusion for the effect of a susceptible IL-1 genotype status to the clinical outcome after periodontal regeneration could be drawn.The need of more qualitative studies to explore a possible association emerges.

View Article: PubMed Central - PubMed

Affiliation: Division of Periodontology, Developmental and Surgical Sciences, School of Dentistry, University of Minnesota, 515 Delaware Street SE, Minneapolis, MN 55455, USA chatz005@umn.edu.

ABSTRACT

Background: The aim of this review is to systematically investigate the effect of a susceptible genotype to periodontitis with the clinical outcomes of periodontal regeneration.

Material and methods: Based on a focused question, an electronic search identified 155 unique citations. Three journals (Journal of Periodontology, Journal of Clinical Periodontology and Journal of Periodontal Research), references of relevant studies and review articles were hand-searched. Two independent reviewers implementing eligibility inclusion criteria selected the studies.

Results: Of the 155, four studies fulfilled the inclusion criteria. All studies were published between 2000 and 2004 and the samples' size was 40 to 86 patients. Polymorphisms of Interleukin-1 (IL-1) gene were included in all. Three out of four studies failed to identify an association between susceptible genotypes to periodontitis and clinical outcomes of periodontal regeneration, while one found an association. The heterogeneity and small number of studies included prevented the conduct of a meta-analysis. No studies were identified evaluating the effect of other genotypes and as a result only IL-1 genotype studies were included.

Conclusions: Within the limits of the present review, no direct conclusion for the effect of a susceptible IL-1 genotype status to the clinical outcome after periodontal regeneration could be drawn. The need of more qualitative studies to explore a possible association emerges.

No MeSH data available.


Related in: MedlinePlus