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Comparative study between two different staging systems (AJCC TNM VS BALLANTYNE'S) for mucosal melanomas of the Head & Neck.

Luna-Ortiz K, Aguilar-Romero M, Villavicencio-Valencia V, Zepeda-Castilla E, Vidrio-Morgado H, Peteuil N, Mosqueda-Taylor A - Med Oral Patol Oral Cir Bucal (2016)

Bottom Line: An up-staging migration effect from Ballantyne's localized disease to moderate-ly and very advanced disease according to AJCC staging system.For locoregional disease the 5-year DFS / OS were 5% / 10% for Ballantyne's system vs. 13.8% / 17.8% and 0 / 0% for AJCC Stages IVA and IVB, respectively.In this series, the TNM staging system for MM of the H&N predicted the prognosis of the disease when comparing with Ballantyne's system.

View Article: PubMed Central - PubMed

Affiliation: Department of Head and Neck Surgery, Instituto Nacional de Cancerologia, Av. San Fernando # 22 Col. Seccion XVI,Tlalpan, Mexico D.F. 14080, kuauhyama@yahoo.com.mx.

ABSTRACT

Background: Mucosal melanoma (MM) of head and neck (H&N) is a rare entity with a quite poor prognosis. Ballantyne's staging system has been commonly used since 1970. In the 7th edition of the AJCC Staging Manual a new chapter for the staging of TNM Classification system for mucosal melanoma (MM) of the head and neck (H&N) has been introduced to reflect the particularly aggressive biological behavior of this neoplasm. The aim of this study was to analyze and compare among Ballantyne's staging system vs TNM H&N in terms of overall survival (OS) and disease-free survival (DFS) in a consecutive population of patients with MM in a cancer centre.

Material and methods: Descriptive analysis of demographic, clinical and pathological variables of MM of the Head & Neck were performed. We compared the survival curves for both systems according to the Kaplan-Meier method using the Log-rank test.

Results: An up-staging migration effect from Ballantyne's localized disease to moderate-ly and very advanced disease according to AJCC staging system. The 5-year DFS and OS for Ballantyne's Localized Disease and AJCC Stage III were 31% and 36% vs. 47% and 50%, respectively. For locoregional disease the 5-year DFS / OS were 5% / 10% for Ballantyne's system vs. 13.8% / 17.8% and 0 / 0% for AJCC Stages IVA and IVB, respectively.

Conclusions: In this series, the TNM staging system for MM of the H&N predicted the prognosis of the disease when comparing with Ballantyne's system.

No MeSH data available.


Related in: MedlinePlus

Overall survival (OS) according to AJCC 7th edition staging system (Kaplan-Meier).
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Figure 4: Overall survival (OS) according to AJCC 7th edition staging system (Kaplan-Meier).

Mentions: There was a 5-year overall survival (OS) for locoregional disease of 10% for Ballantyne’s and 17.8 and 0% for AJCC Stages IVA and IVB (Figs. 3,4). The mean overall survival for these groups was 7 months vs. 7 months and 5 months, respectively.


Comparative study between two different staging systems (AJCC TNM VS BALLANTYNE'S) for mucosal melanomas of the Head & Neck.

Luna-Ortiz K, Aguilar-Romero M, Villavicencio-Valencia V, Zepeda-Castilla E, Vidrio-Morgado H, Peteuil N, Mosqueda-Taylor A - Med Oral Patol Oral Cir Bucal (2016)

Overall survival (OS) according to AJCC 7th edition staging system (Kaplan-Meier).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4920455&req=5

Figure 4: Overall survival (OS) according to AJCC 7th edition staging system (Kaplan-Meier).
Mentions: There was a 5-year overall survival (OS) for locoregional disease of 10% for Ballantyne’s and 17.8 and 0% for AJCC Stages IVA and IVB (Figs. 3,4). The mean overall survival for these groups was 7 months vs. 7 months and 5 months, respectively.

Bottom Line: An up-staging migration effect from Ballantyne's localized disease to moderate-ly and very advanced disease according to AJCC staging system.For locoregional disease the 5-year DFS / OS were 5% / 10% for Ballantyne's system vs. 13.8% / 17.8% and 0 / 0% for AJCC Stages IVA and IVB, respectively.In this series, the TNM staging system for MM of the H&N predicted the prognosis of the disease when comparing with Ballantyne's system.

View Article: PubMed Central - PubMed

Affiliation: Department of Head and Neck Surgery, Instituto Nacional de Cancerologia, Av. San Fernando # 22 Col. Seccion XVI,Tlalpan, Mexico D.F. 14080, kuauhyama@yahoo.com.mx.

ABSTRACT

Background: Mucosal melanoma (MM) of head and neck (H&N) is a rare entity with a quite poor prognosis. Ballantyne's staging system has been commonly used since 1970. In the 7th edition of the AJCC Staging Manual a new chapter for the staging of TNM Classification system for mucosal melanoma (MM) of the head and neck (H&N) has been introduced to reflect the particularly aggressive biological behavior of this neoplasm. The aim of this study was to analyze and compare among Ballantyne's staging system vs TNM H&N in terms of overall survival (OS) and disease-free survival (DFS) in a consecutive population of patients with MM in a cancer centre.

Material and methods: Descriptive analysis of demographic, clinical and pathological variables of MM of the Head & Neck were performed. We compared the survival curves for both systems according to the Kaplan-Meier method using the Log-rank test.

Results: An up-staging migration effect from Ballantyne's localized disease to moderate-ly and very advanced disease according to AJCC staging system. The 5-year DFS and OS for Ballantyne's Localized Disease and AJCC Stage III were 31% and 36% vs. 47% and 50%, respectively. For locoregional disease the 5-year DFS / OS were 5% / 10% for Ballantyne's system vs. 13.8% / 17.8% and 0 / 0% for AJCC Stages IVA and IVB, respectively.

Conclusions: In this series, the TNM staging system for MM of the H&N predicted the prognosis of the disease when comparing with Ballantyne's system.

No MeSH data available.


Related in: MedlinePlus