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Prevalence of G6721T polymorphism of XRCC7 in an Iranian population.

Saadat M, Saadat I - EXCLI J (2012)

Bottom Line: There was no significant difference between males and females for the XRCC7 polymorphism (χ(2)=1.275, df=2, P=0.529).The study population was at Hardy-Weinberg equilibrium for the XRCC7 polymorphism (χ(2)=0.980, df=1, P=0.323).The allelic frequency of the G allele showed high frequency in Iranian population compared to other populations.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran Institute of Biotechnology, Shiraz University, Shiraz, Iran.

ABSTRACT
Genetic polymorphism G6721T (rs.7003908) in gene encoding DNA-dependent protein kinase (DNA-PKcs, encoded by the XRCC7 gene) has been defined. In order to get more insight into the genetic structure of Iranian population the present study was carried out on Iranian Persian population living in Shiraz (Fars province, southwest Iran). The total study subjects consisted of 935 (195 males, 740 females) unrelated healthy individuals. Genotypes of XRCC7 G6721T were detected by PCR-RFLP based method. There was no significant difference between males and females for the XRCC7 polymorphism (χ(2)=1.275, df=2, P=0.529). Prevalence of the G allele was 0.473 (95 % CI: 0.441-0.505) in our sample. The study population was at Hardy-Weinberg equilibrium for the XRCC7 polymorphism (χ(2)=0.980, df=1, P=0.323). The allelic frequency of the G allele showed high frequency in Iranian population compared to other populations.

No MeSH data available.


Distribution of the G7621T XRCC7 genotypes among healthy blood donors in Shiraz population (southern Iran)
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T1: Distribution of the G7621T XRCC7 genotypes among healthy blood donors in Shiraz population (southern Iran)

Mentions: Genotypic frequencies of XRCC7 among study population are shown in Table 1(Tab. 1). There were no significant gender differences for the XRCC7 polymorphism (χ2=1.275, df=2, P=0.529). Prevalence of the G allele for the total study group was 0.473 (95 % CI: 0.441-0.505) (Table 2(Tab. 2)). The study population was at Hardy-Weinberg equilibrium (χ2=0.980, df=1, P=0.323).


Prevalence of G6721T polymorphism of XRCC7 in an Iranian population.

Saadat M, Saadat I - EXCLI J (2012)

Distribution of the G7621T XRCC7 genotypes among healthy blood donors in Shiraz population (southern Iran)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4920041&req=5

T1: Distribution of the G7621T XRCC7 genotypes among healthy blood donors in Shiraz population (southern Iran)
Mentions: Genotypic frequencies of XRCC7 among study population are shown in Table 1(Tab. 1). There were no significant gender differences for the XRCC7 polymorphism (χ2=1.275, df=2, P=0.529). Prevalence of the G allele for the total study group was 0.473 (95 % CI: 0.441-0.505) (Table 2(Tab. 2)). The study population was at Hardy-Weinberg equilibrium (χ2=0.980, df=1, P=0.323).

Bottom Line: There was no significant difference between males and females for the XRCC7 polymorphism (χ(2)=1.275, df=2, P=0.529).The study population was at Hardy-Weinberg equilibrium for the XRCC7 polymorphism (χ(2)=0.980, df=1, P=0.323).The allelic frequency of the G allele showed high frequency in Iranian population compared to other populations.

View Article: PubMed Central - PubMed

Affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran Institute of Biotechnology, Shiraz University, Shiraz, Iran.

ABSTRACT
Genetic polymorphism G6721T (rs.7003908) in gene encoding DNA-dependent protein kinase (DNA-PKcs, encoded by the XRCC7 gene) has been defined. In order to get more insight into the genetic structure of Iranian population the present study was carried out on Iranian Persian population living in Shiraz (Fars province, southwest Iran). The total study subjects consisted of 935 (195 males, 740 females) unrelated healthy individuals. Genotypes of XRCC7 G6721T were detected by PCR-RFLP based method. There was no significant difference between males and females for the XRCC7 polymorphism (χ(2)=1.275, df=2, P=0.529). Prevalence of the G allele was 0.473 (95 % CI: 0.441-0.505) in our sample. The study population was at Hardy-Weinberg equilibrium for the XRCC7 polymorphism (χ(2)=0.980, df=1, P=0.323). The allelic frequency of the G allele showed high frequency in Iranian population compared to other populations.

No MeSH data available.