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Comparison of the Early Clinical Outcomes between Combined Small-Incision Lenticule Extraction and Collagen Cross-Linking versus SMILE for Myopia.

Ng AL, Chan TC, Cheng GP, Jhanji V, Ye C, Woo VC, Lai JS - J Ophthalmol (2016)

Bottom Line: Results.SMILE Xtra had good overall safety profile and predictability at 6 months.However, when compared with control, the safety index and efficacy index were statistically significantly lower in the early postoperative period.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

ABSTRACT
Background. To compare the early outcome of combined SMILE and collagen crosslinking (SMILE Xtra) with SMILE. Method. Prospective, comparative interventional study of 21 eyes receiving SMILE Xtra using a low energy protocol and 32 control eyes receiving SMILE only. The outcomes were compared at 1, 3, and 6 months postoperatively. Results. Both groups had myopia with spherical equivalent refraction (SEQ) > 4.00 D. The SMILE Xtra group had thinner preoperative central corneal thickness and residual stromal bed thickness (p < 0.021). At 6 months, no eyes lost more than 1 line in corrected distance visual acuity. The safety index was 0.96 ± 0.06 and 1.00 ± 0.00 in SMILE Xtra and control, respectively (p < 0.001). 89% and 94% of eyes were within ±0.50 D of target refraction, respectively, with the mean error in SEQ correction being -0.17 ± 0.26 D for SMILE Xtra and +0.03 ± 0.25 D for control (p = 0.021). The efficacy index was 0.88 ± 0.13 and 0.97 ± 0.06, respectively (p = 0.005). Conclusion. SMILE Xtra had good overall safety profile and predictability at 6 months. However, when compared with control, the safety index and efficacy index were statistically significantly lower in the early postoperative period.

No MeSH data available.


Related in: MedlinePlus

Refractive outcomes for small-incision lenticule extraction (SMILE) and combined SMILE with cross-linking (SMILE Xtra) at the end of 6 months postoperatively: (a) attempted versus achieved manifest spherical equivalent refraction (SEQ) correction in diopters for SMILE (left) and SMILE Xtra (right); (b) percentages of eyes within different diopter ranges of the intended correction in SEQ after SMILE and SMILE Xtra; (c) percentage of eyes attaining specified levels of astigmatism before (white) and after (grey) SMILE and SMILE Xtra.
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Related In: Results  -  Collection


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fig2: Refractive outcomes for small-incision lenticule extraction (SMILE) and combined SMILE with cross-linking (SMILE Xtra) at the end of 6 months postoperatively: (a) attempted versus achieved manifest spherical equivalent refraction (SEQ) correction in diopters for SMILE (left) and SMILE Xtra (right); (b) percentages of eyes within different diopter ranges of the intended correction in SEQ after SMILE and SMILE Xtra; (c) percentage of eyes attaining specified levels of astigmatism before (white) and after (grey) SMILE and SMILE Xtra.

Mentions: The mean spherical equivalence reduced from −7.08 D to −0.17 D at 6 months postoperatively in SMILE Xtra and from −6.56 D to +0.03 D in control. At 6 months, 94% and 97% of eyes in the SMILE group were maintained within ±0.50 D in the SEQ and astigmatism correction, respectively. In SMILE Xtra group, 89% and 94% of eyes were within ±0.50 D in SEQ and astigmatism correction, respectively (Figure 2). The mean errors in the correction in the SEQ at 6 months were −0.17 ± 0.26 D for SMILE Xtra and +0.03 ± 0.25 D for control (p = 0.021). Figure 3 shows that a slight myopic shifting trend is demonstrated in the SMILE Xtra group while the SMILE group demonstrated stability over 6 months.


Comparison of the Early Clinical Outcomes between Combined Small-Incision Lenticule Extraction and Collagen Cross-Linking versus SMILE for Myopia.

Ng AL, Chan TC, Cheng GP, Jhanji V, Ye C, Woo VC, Lai JS - J Ophthalmol (2016)

Refractive outcomes for small-incision lenticule extraction (SMILE) and combined SMILE with cross-linking (SMILE Xtra) at the end of 6 months postoperatively: (a) attempted versus achieved manifest spherical equivalent refraction (SEQ) correction in diopters for SMILE (left) and SMILE Xtra (right); (b) percentages of eyes within different diopter ranges of the intended correction in SEQ after SMILE and SMILE Xtra; (c) percentage of eyes attaining specified levels of astigmatism before (white) and after (grey) SMILE and SMILE Xtra.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4863112&req=5

fig2: Refractive outcomes for small-incision lenticule extraction (SMILE) and combined SMILE with cross-linking (SMILE Xtra) at the end of 6 months postoperatively: (a) attempted versus achieved manifest spherical equivalent refraction (SEQ) correction in diopters for SMILE (left) and SMILE Xtra (right); (b) percentages of eyes within different diopter ranges of the intended correction in SEQ after SMILE and SMILE Xtra; (c) percentage of eyes attaining specified levels of astigmatism before (white) and after (grey) SMILE and SMILE Xtra.
Mentions: The mean spherical equivalence reduced from −7.08 D to −0.17 D at 6 months postoperatively in SMILE Xtra and from −6.56 D to +0.03 D in control. At 6 months, 94% and 97% of eyes in the SMILE group were maintained within ±0.50 D in the SEQ and astigmatism correction, respectively. In SMILE Xtra group, 89% and 94% of eyes were within ±0.50 D in SEQ and astigmatism correction, respectively (Figure 2). The mean errors in the correction in the SEQ at 6 months were −0.17 ± 0.26 D for SMILE Xtra and +0.03 ± 0.25 D for control (p = 0.021). Figure 3 shows that a slight myopic shifting trend is demonstrated in the SMILE Xtra group while the SMILE group demonstrated stability over 6 months.

Bottom Line: Results.SMILE Xtra had good overall safety profile and predictability at 6 months.However, when compared with control, the safety index and efficacy index were statistically significantly lower in the early postoperative period.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

ABSTRACT
Background. To compare the early outcome of combined SMILE and collagen crosslinking (SMILE Xtra) with SMILE. Method. Prospective, comparative interventional study of 21 eyes receiving SMILE Xtra using a low energy protocol and 32 control eyes receiving SMILE only. The outcomes were compared at 1, 3, and 6 months postoperatively. Results. Both groups had myopia with spherical equivalent refraction (SEQ) > 4.00 D. The SMILE Xtra group had thinner preoperative central corneal thickness and residual stromal bed thickness (p < 0.021). At 6 months, no eyes lost more than 1 line in corrected distance visual acuity. The safety index was 0.96 ± 0.06 and 1.00 ± 0.00 in SMILE Xtra and control, respectively (p < 0.001). 89% and 94% of eyes were within ±0.50 D of target refraction, respectively, with the mean error in SEQ correction being -0.17 ± 0.26 D for SMILE Xtra and +0.03 ± 0.25 D for control (p = 0.021). The efficacy index was 0.88 ± 0.13 and 0.97 ± 0.06, respectively (p = 0.005). Conclusion. SMILE Xtra had good overall safety profile and predictability at 6 months. However, when compared with control, the safety index and efficacy index were statistically significantly lower in the early postoperative period.

No MeSH data available.


Related in: MedlinePlus