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TP53 Mutations and Survival in Osteosarcoma Patients: A Meta-Analysis of Published Data.

Chen Z, Guo J, Zhang K, Guo Y - Dis. Markers (2016)

Bottom Line: However, the results were controversial.The risk ratio (RR) with a 95% confidence interval (95% CI) was calculated to assess the effect of TP53 mutations on 2-year overall survival.These data suggested that TP53 mutations had an unfavorable impact on 2-year overall survival when compared to the counterparts with wild type (WT) TP53 (RR: 1.79; 95% CI: 1.12 to 2.84; P = 0.01; I (2) = 0%).

View Article: PubMed Central - PubMed

Affiliation: Luoyang Orthopedic Hospital of Henan Province, Luoyang 471000, China.

ABSTRACT
Several research groups have examined the association between TP53 mutations and prognosis in human osteosarcoma. However, the results were controversial. The purpose of this study was to evaluate the prognostic value of TP53 mutations in osteosarcoma patients. A meta-analysis was conducted with all eligible studies which quantitatively evaluated the relationship between TP53 mutations and clinical outcome of osteosarcoma patients. Eight studies with a total of 210 patients with osteosarcoma were included in this meta-analysis. The risk ratio (RR) with a 95% confidence interval (95% CI) was calculated to assess the effect of TP53 mutations on 2-year overall survival. The quantitative synthesis of 8 published studies showed that TP53 mutations were associated with 2-year overall survival in osteosarcoma patients. These data suggested that TP53 mutations had an unfavorable impact on 2-year overall survival when compared to the counterparts with wild type (WT) TP53 (RR: 1.79; 95% CI: 1.12 to 2.84; P = 0.01; I (2) = 0%). There was no between-study heterogeneity. TP53 mutations are an effective prognostic marker for survival of patients with osteosarcoma. However, further large-scale prospective trials should be performed to clarify the prognostic value of TP53 mutations on 3- or 5-year survival in osteosarcoma patients.

No MeSH data available.


Related in: MedlinePlus

Meta-analysis (forest plot) of the 8 studies evaluating TP53 mutations in osteosarcoma for the risk of 2-year death. The name of the lead author and the RR with 95% confidence intervals are shown in each study. The total RR and 95% confidence intervals are summarized with fixed effects models.
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fig2: Meta-analysis (forest plot) of the 8 studies evaluating TP53 mutations in osteosarcoma for the risk of 2-year death. The name of the lead author and the RR with 95% confidence intervals are shown in each study. The total RR and 95% confidence intervals are summarized with fixed effects models.

Mentions: There was no heterogeneity among these included studies (I2 = 0%, Figure 2) and a fixed effects model was chosen. Meta-analysis of those 8 studies showed that TP53 mutations were remarkably associated with a higher risk of death within 2 years compared with their counterparts with WT TP53 (Figure 2, RR: 1.79; 95% CI: 1.12 to 2.84; P = 0.01). Sensitivity analysis showed that the pooled RR was stable and was not remarkably changed when each study was omitted (Figure 3). These analyses suggested that TP53 mutations in patients with osteosarcoma predicted poor 2-year overall survival, whereas more clinical studies should be conducted taking into account the age, sex, metastasis, histological grades, primary sites, and treatment of osteosarcoma patients.


TP53 Mutations and Survival in Osteosarcoma Patients: A Meta-Analysis of Published Data.

Chen Z, Guo J, Zhang K, Guo Y - Dis. Markers (2016)

Meta-analysis (forest plot) of the 8 studies evaluating TP53 mutations in osteosarcoma for the risk of 2-year death. The name of the lead author and the RR with 95% confidence intervals are shown in each study. The total RR and 95% confidence intervals are summarized with fixed effects models.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4863100&req=5

fig2: Meta-analysis (forest plot) of the 8 studies evaluating TP53 mutations in osteosarcoma for the risk of 2-year death. The name of the lead author and the RR with 95% confidence intervals are shown in each study. The total RR and 95% confidence intervals are summarized with fixed effects models.
Mentions: There was no heterogeneity among these included studies (I2 = 0%, Figure 2) and a fixed effects model was chosen. Meta-analysis of those 8 studies showed that TP53 mutations were remarkably associated with a higher risk of death within 2 years compared with their counterparts with WT TP53 (Figure 2, RR: 1.79; 95% CI: 1.12 to 2.84; P = 0.01). Sensitivity analysis showed that the pooled RR was stable and was not remarkably changed when each study was omitted (Figure 3). These analyses suggested that TP53 mutations in patients with osteosarcoma predicted poor 2-year overall survival, whereas more clinical studies should be conducted taking into account the age, sex, metastasis, histological grades, primary sites, and treatment of osteosarcoma patients.

Bottom Line: However, the results were controversial.The risk ratio (RR) with a 95% confidence interval (95% CI) was calculated to assess the effect of TP53 mutations on 2-year overall survival.These data suggested that TP53 mutations had an unfavorable impact on 2-year overall survival when compared to the counterparts with wild type (WT) TP53 (RR: 1.79; 95% CI: 1.12 to 2.84; P = 0.01; I (2) = 0%).

View Article: PubMed Central - PubMed

Affiliation: Luoyang Orthopedic Hospital of Henan Province, Luoyang 471000, China.

ABSTRACT
Several research groups have examined the association between TP53 mutations and prognosis in human osteosarcoma. However, the results were controversial. The purpose of this study was to evaluate the prognostic value of TP53 mutations in osteosarcoma patients. A meta-analysis was conducted with all eligible studies which quantitatively evaluated the relationship between TP53 mutations and clinical outcome of osteosarcoma patients. Eight studies with a total of 210 patients with osteosarcoma were included in this meta-analysis. The risk ratio (RR) with a 95% confidence interval (95% CI) was calculated to assess the effect of TP53 mutations on 2-year overall survival. The quantitative synthesis of 8 published studies showed that TP53 mutations were associated with 2-year overall survival in osteosarcoma patients. These data suggested that TP53 mutations had an unfavorable impact on 2-year overall survival when compared to the counterparts with wild type (WT) TP53 (RR: 1.79; 95% CI: 1.12 to 2.84; P = 0.01; I (2) = 0%). There was no between-study heterogeneity. TP53 mutations are an effective prognostic marker for survival of patients with osteosarcoma. However, further large-scale prospective trials should be performed to clarify the prognostic value of TP53 mutations on 3- or 5-year survival in osteosarcoma patients.

No MeSH data available.


Related in: MedlinePlus