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Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis.

Xiao BH, Shi M, Chen H, Cui S, Wu Y, Gao XH, Chen HD - Biomed Res Int (2016)

Bottom Line: However, the results were controversial.Results.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang 110001, China.

ABSTRACT
Abnormality of glutathione peroxidase (GPx) is involved in the etiology and pathogenesis of vitiligo. However, the results were controversial. Aim. The purpose of this meta-analysis is to compare the levels of GPx between vitiligo patients and healthy controls. Methods. Relevant published articles were searched according to eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% confidence interval (CI). Results. Twenty-three studies with a total of 1076 vitiligo patients and 770 healthy controls were included. The pooled meta-analysis showed that patients with vitiligo had equivalent levels of GPx with the healthy controls (SMD = -0.47, 95% CI: -1.03 to 0.08, and p = 0.095). Further subgroup analysis showed that the GPx levels of Asian patients or segmental vitiligo patients were, respectively, lower than those of healthy controls (Asian: SMD = -0.47, 95% CI: -1.08 to 0.14, and p = 0.001; segmental: SMD = -3.59, 95% CI: -6.38 to -0.80, and p = 0.012). Furthermore, the GPx levels in serum/plasma were significantly decreased in either stable or active vitiligo patients, comparing to healthy controls (stable: SMD = -2.01, 95% CI: -3.52 to -0.49, and p = 0.009; active: SMD = -2.34, 95% CI: -4.07 to -0.61, and p = 0.008). Conclusion. This meta-analysis showed a significant association between low GPx level and vitiligo.

No MeSH data available.


Related in: MedlinePlus

Subgroup analyses of studies in glutathione peroxidase levels for subjects with vitiligo versus healthy controls stratified by (a) sample sources and (b) races.
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fig3: Subgroup analyses of studies in glutathione peroxidase levels for subjects with vitiligo versus healthy controls stratified by (a) sample sources and (b) races.

Mentions: Further subgroup analysis stratified by sample sources indicated that vitiligo patients had higher GPx levels than controls in skin (SMD = 1.49, 95% CI: 0.06 to 2.91, and p = 0.041) and lower GPx levels than controls in blood (SMD = −1.06, 95% CI: −2.06 to −0.06, and p = 0.038). No difference was seen in the source of serum (SMD = −1.24, 95% CI: −2.79 to 0.31, and p = 0.117), plasma (SMD = −0.05, 95% CI: −1.43 to 1.34, and p = 0.948), erythrocyte (SMD = −0.97, 95% CI: −1.94 to 0.00, and p = 0.050), or blister fluid (SMD = −0.29, 95% CI: −1.56 to 0.98, and p = 0.657) (Figure 3(a)). The analysis stratified by race indicated that vitiligo patients in Asian populations had lower GPx levels than controls (SMD = −0.47, 95% CI: −1.08 to 0.14, and p = 0.001), but no difference was shown in Caucasian populations (SMD = 0.259, 95% CI: −0.28 to 0.80, and p = 0.346) (Figure 3(b)). Five articles were included in the subgroup analyses stratified by stage and sample source of serum/plasma (Table 3). The results indicated that the vitiligo patients at either stable stage or active stage had lower GPx levels in serum/plasma compared to controls (stable: SMD = −2.01, 95% CI: −3.52 to −0.49, and p = 0.009; active: SMD = −2.34, 95% CI: −4.07 to −0.61, and p = 0.008) (Figures 4(a) and 4(b)). No significant difference was observed between stable stage and active stage (SMD = 0.50, 95% CI: −0.02 to 1.01, and p = 0.058). Three articles were included in the subgroup analyses stratified by vitiligo type (Table 4). Segmental vitiligo patients had lower GPx levels compared to controls (SMD = −3.59, 95% CI: −6.38 to −0.80, and p = 0.012). No significant difference was observed between nonsegmental vitiligo patients and controls (SMD = −2.81, 95% CI: −5.71 to 0.10, and p = 0.058) or between segmental and nonsegmental vitiligo patients (SMD = −0.18, 95% CI: −0.47 to 0.11, and p = 0.230).


Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis.

Xiao BH, Shi M, Chen H, Cui S, Wu Y, Gao XH, Chen HD - Biomed Res Int (2016)

Subgroup analyses of studies in glutathione peroxidase levels for subjects with vitiligo versus healthy controls stratified by (a) sample sources and (b) races.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4863094&req=5

fig3: Subgroup analyses of studies in glutathione peroxidase levels for subjects with vitiligo versus healthy controls stratified by (a) sample sources and (b) races.
Mentions: Further subgroup analysis stratified by sample sources indicated that vitiligo patients had higher GPx levels than controls in skin (SMD = 1.49, 95% CI: 0.06 to 2.91, and p = 0.041) and lower GPx levels than controls in blood (SMD = −1.06, 95% CI: −2.06 to −0.06, and p = 0.038). No difference was seen in the source of serum (SMD = −1.24, 95% CI: −2.79 to 0.31, and p = 0.117), plasma (SMD = −0.05, 95% CI: −1.43 to 1.34, and p = 0.948), erythrocyte (SMD = −0.97, 95% CI: −1.94 to 0.00, and p = 0.050), or blister fluid (SMD = −0.29, 95% CI: −1.56 to 0.98, and p = 0.657) (Figure 3(a)). The analysis stratified by race indicated that vitiligo patients in Asian populations had lower GPx levels than controls (SMD = −0.47, 95% CI: −1.08 to 0.14, and p = 0.001), but no difference was shown in Caucasian populations (SMD = 0.259, 95% CI: −0.28 to 0.80, and p = 0.346) (Figure 3(b)). Five articles were included in the subgroup analyses stratified by stage and sample source of serum/plasma (Table 3). The results indicated that the vitiligo patients at either stable stage or active stage had lower GPx levels in serum/plasma compared to controls (stable: SMD = −2.01, 95% CI: −3.52 to −0.49, and p = 0.009; active: SMD = −2.34, 95% CI: −4.07 to −0.61, and p = 0.008) (Figures 4(a) and 4(b)). No significant difference was observed between stable stage and active stage (SMD = 0.50, 95% CI: −0.02 to 1.01, and p = 0.058). Three articles were included in the subgroup analyses stratified by vitiligo type (Table 4). Segmental vitiligo patients had lower GPx levels compared to controls (SMD = −3.59, 95% CI: −6.38 to −0.80, and p = 0.012). No significant difference was observed between nonsegmental vitiligo patients and controls (SMD = −2.81, 95% CI: −5.71 to 0.10, and p = 0.058) or between segmental and nonsegmental vitiligo patients (SMD = −0.18, 95% CI: −0.47 to 0.11, and p = 0.230).

Bottom Line: However, the results were controversial.Results.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang 110001, China.

ABSTRACT
Abnormality of glutathione peroxidase (GPx) is involved in the etiology and pathogenesis of vitiligo. However, the results were controversial. Aim. The purpose of this meta-analysis is to compare the levels of GPx between vitiligo patients and healthy controls. Methods. Relevant published articles were searched according to eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% confidence interval (CI). Results. Twenty-three studies with a total of 1076 vitiligo patients and 770 healthy controls were included. The pooled meta-analysis showed that patients with vitiligo had equivalent levels of GPx with the healthy controls (SMD = -0.47, 95% CI: -1.03 to 0.08, and p = 0.095). Further subgroup analysis showed that the GPx levels of Asian patients or segmental vitiligo patients were, respectively, lower than those of healthy controls (Asian: SMD = -0.47, 95% CI: -1.08 to 0.14, and p = 0.001; segmental: SMD = -3.59, 95% CI: -6.38 to -0.80, and p = 0.012). Furthermore, the GPx levels in serum/plasma were significantly decreased in either stable or active vitiligo patients, comparing to healthy controls (stable: SMD = -2.01, 95% CI: -3.52 to -0.49, and p = 0.009; active: SMD = -2.34, 95% CI: -4.07 to -0.61, and p = 0.008). Conclusion. This meta-analysis showed a significant association between low GPx level and vitiligo.

No MeSH data available.


Related in: MedlinePlus