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A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound Healing.

Jinno C, Morimoto N, Ito R, Sakamoto M, Ogino S, Taira T, Suzuki S - Biomed Res Int (2016)

Bottom Line: The objective of this study was to compare the effectiveness of the collagen-gelatin sponge (CGS) with that of the collagen sponge (CS) in dermis-like tissue regeneration.There were no significant differences in the CGS without bFGF and CS groups.The effects on epithelialization, granulation, and vascularization of wound healing demonstrated that, as a scaffold, CGSs are equal or superior to conventional CSs.

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-machi, Syougoin, Sakyou-ku, Kyoto City, Kyoto 606-8507, Japan.

ABSTRACT
The objective of this study was to compare the effectiveness of the collagen-gelatin sponge (CGS) with that of the collagen sponge (CS) in dermis-like tissue regeneration. CGS, which achieves the sustained release of basic fibroblast growth factor (bFGF), is a promising material in wound healing. In the present study, we evaluated and compared CGSs and conventional CSs. We prepared 8 mm full-thickness skin defects on the backs of rats. Either CGSs or CSs were impregnated with normal saline solution (NSS) or 7 μg/cm(2) of bFGF solution and implanted into the defects. At 1 and 2 weeks after implantation, tissue specimens were obtained from the rats of each group (n = 3, total n = 24). The wound area, neoepithelial length, dermis-like tissue area, and the number and area of capillaries were evaluated at 1 and 2 weeks after implantation. There were no significant differences in the CGS without bFGF and CS groups. Significant improvements were observed in the neoepithelial length, the dermis-like tissue area, and the number of newly formed capillaries in the group of rats that received CGSs impregnated with bFGF. The effects on epithelialization, granulation, and vascularization of wound healing demonstrated that, as a scaffold, CGSs are equal or superior to conventional CSs.

No MeSH data available.


Related in: MedlinePlus

The comparison of the area of newly formed dermis-like tissue at 2 weeks. The newly formed dermis-like tissue in the wounds of the CGS-bFGF group was significantly larger than that of the CS-NSS and CS-bFGF groups at 2 weeks (∗∗P < 0.01).
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fig6: The comparison of the area of newly formed dermis-like tissue at 2 weeks. The newly formed dermis-like tissue in the wounds of the CGS-bFGF group was significantly larger than that of the CS-NSS and CS-bFGF groups at 2 weeks (∗∗P < 0.01).

Mentions: The regenerated area of dermis-like tissue at two weeks after implantation is shown in Figure 5. The area of dermis-like tissue in the CGS-bFGF group was significantly larger than that in the CS-NSS and CS-bFGF groups (P < 0.01) (Figure 6).


A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound Healing.

Jinno C, Morimoto N, Ito R, Sakamoto M, Ogino S, Taira T, Suzuki S - Biomed Res Int (2016)

The comparison of the area of newly formed dermis-like tissue at 2 weeks. The newly formed dermis-like tissue in the wounds of the CGS-bFGF group was significantly larger than that of the CS-NSS and CS-bFGF groups at 2 weeks (∗∗P < 0.01).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4863089&req=5

fig6: The comparison of the area of newly formed dermis-like tissue at 2 weeks. The newly formed dermis-like tissue in the wounds of the CGS-bFGF group was significantly larger than that of the CS-NSS and CS-bFGF groups at 2 weeks (∗∗P < 0.01).
Mentions: The regenerated area of dermis-like tissue at two weeks after implantation is shown in Figure 5. The area of dermis-like tissue in the CGS-bFGF group was significantly larger than that in the CS-NSS and CS-bFGF groups (P < 0.01) (Figure 6).

Bottom Line: The objective of this study was to compare the effectiveness of the collagen-gelatin sponge (CGS) with that of the collagen sponge (CS) in dermis-like tissue regeneration.There were no significant differences in the CGS without bFGF and CS groups.The effects on epithelialization, granulation, and vascularization of wound healing demonstrated that, as a scaffold, CGSs are equal or superior to conventional CSs.

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-machi, Syougoin, Sakyou-ku, Kyoto City, Kyoto 606-8507, Japan.

ABSTRACT
The objective of this study was to compare the effectiveness of the collagen-gelatin sponge (CGS) with that of the collagen sponge (CS) in dermis-like tissue regeneration. CGS, which achieves the sustained release of basic fibroblast growth factor (bFGF), is a promising material in wound healing. In the present study, we evaluated and compared CGSs and conventional CSs. We prepared 8 mm full-thickness skin defects on the backs of rats. Either CGSs or CSs were impregnated with normal saline solution (NSS) or 7 μg/cm(2) of bFGF solution and implanted into the defects. At 1 and 2 weeks after implantation, tissue specimens were obtained from the rats of each group (n = 3, total n = 24). The wound area, neoepithelial length, dermis-like tissue area, and the number and area of capillaries were evaluated at 1 and 2 weeks after implantation. There were no significant differences in the CGS without bFGF and CS groups. Significant improvements were observed in the neoepithelial length, the dermis-like tissue area, and the number of newly formed capillaries in the group of rats that received CGSs impregnated with bFGF. The effects on epithelialization, granulation, and vascularization of wound healing demonstrated that, as a scaffold, CGSs are equal or superior to conventional CSs.

No MeSH data available.


Related in: MedlinePlus