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Epidemiological and histopathological patterns of salivary gland tumors in Cameroon.

Sando Z, Fokouo JV, Mebada AO, Djomou F, NDjolo A, Oyono JL - Pan Afr Med J (2016)

Bottom Line: Pleomorphic adenoma (60.36%) was the most common benign tumor.Adenoid cystic carcinoma (31%), mucoepidermoid carcinoma (22.4%) and adenocarcinoma (19%) were the most common malignant tumors.Palate (66.7%), cheek (30%) and lips (3.3%) were the sites were the minor salivary glands were mostly involved.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine and Biomedical Sciences (FMBS) of the University of Yaoundé I, Yaoundé, Cameroon; Pathology Service of Gyneco-Obstetric and Pediatric Hospital, Yaoundé, Cameroon.

ABSTRACT

Introduction: Tumors of salivary glands are rare. According to Johns and Goldsmith in 1989, their annual incidence is less than 1/100000 without noteworthy geographical gap. But other authors suggest that their distribution may vary according to the race and geographical location. In Cameroon, existing studies give incomplete data. Hence, we underwent this study in order to draw the general profile of salivary gland tumors in Cameroon.

Methods: A retrospective study was carried out on the period spanning from January 2000 to December 2010 (11 years). It was done in nine Pathology services of different hospitals in Yaoundé, Douala and Bamenda. We consulted the archive registers of those services, retaining any patient with salivary gland tumor, whatever the histological type or location. Information gathered was the year of diagnosis, the service, the age and sex, the site of the tumor (gland) the histological type and the benign/ malignant character.

Results: We recruited a total of 275 files. Women were 56% (154/275) and men 44% (121/275) of the sample. Fifty eight tumors were malignant (21.9%) while 217 were benign (78.1%). The overall mean age was 37.44 years, with extremes between 1 and 84 years. Pleomorphic adenoma (60.36%) was the most common benign tumor. Adenoid cystic carcinoma (31%), mucoepidermoid carcinoma (22.4%) and adenocarcinoma (19%) were the most common malignant tumors. Palate (66.7%), cheek (30%) and lips (3.3%) were the sites were the minor salivary glands were mostly involved.

Conclusion: The differences with western world authors suggest a geographical variability of salivary gland tumors.

No MeSH data available.


Related in: MedlinePlus

Distribution of patients according to age range and histology; the red line represents the slope of the frequency of malignant tumors
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Figure 0001: Distribution of patients according to age range and histology; the red line represents the slope of the frequency of malignant tumors

Mentions: We recruited a total of 275 files from the nine hospital centers. Females were 154 (56%) and males 121 (44%) of the sample. There was an increase of the number of cases per year as from 2007, with a peak in 2009 being 45 cases. The distribution of cases per center was as follows: Mezam Polyclinic (63), Centre Pasteur du Cameroun (58), Douala General Hospital (39), Yaoundé University Hospital Center (33), Association Pathologie et Dévelopement (29), Yaoundé General Hospital (19), Douala Laquintinie Hospital (15), Yaoundé central Hospital (12) and Yaoundé Gyneco-Obstetric and Pediatric Hospital (7). The detail of the contribution of each pathology center is given in Table 1. Fifty eight tumors were malignant (21.1%) while 217 were benign (78.9%). The mean age of the patients was 37.44 (SD: 54.7) years with extremes of 1 and 84 years. Mean age was 46.9 (SD: 43.13) years with extremes of 18 and 79 years in the patients with malignant tumors versus 34.9 (SD: 39.6) years with extremes of 1 and 84 years in those with benignant tumors (p = 0.03). The distribution of tumors according to age range and histology is given in Figure 1. We obtained the sequence of 135:109:30 for parotid, submandibular and accessory salivary glands respectively, thus giving a parotid/submandibular gland ratio of 1.23 (Table 2). Pleomorphic adenoma (60.36% of benign tumors and 47.7% of all tumors) was the most frequent benign tumor. The cystic adenoid carcinoma was the most frequent malignant tumor (31%of them), followed by the mucoepidermoid carcinoma (22.4%), and adenocarcinoma (19%). There were 30 cases (20%) of accessory salivary gland involvement, of which 20% were malignant tumors. The palate (66.7%), the cheek (30%) and the lips (3.3%) were the sites affected by accessory salivary gland tumors. There were 54 inflammatory pseudo tumors, representing 24.8% of benign tumors and 19.6% of the sample (Table 3). We compared our results to those of other authors. It shows a similarity between African results, contrary to Western World literature (Table 4).


Epidemiological and histopathological patterns of salivary gland tumors in Cameroon.

Sando Z, Fokouo JV, Mebada AO, Djomou F, NDjolo A, Oyono JL - Pan Afr Med J (2016)

Distribution of patients according to age range and histology; the red line represents the slope of the frequency of malignant tumors
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4862794&req=5

Figure 0001: Distribution of patients according to age range and histology; the red line represents the slope of the frequency of malignant tumors
Mentions: We recruited a total of 275 files from the nine hospital centers. Females were 154 (56%) and males 121 (44%) of the sample. There was an increase of the number of cases per year as from 2007, with a peak in 2009 being 45 cases. The distribution of cases per center was as follows: Mezam Polyclinic (63), Centre Pasteur du Cameroun (58), Douala General Hospital (39), Yaoundé University Hospital Center (33), Association Pathologie et Dévelopement (29), Yaoundé General Hospital (19), Douala Laquintinie Hospital (15), Yaoundé central Hospital (12) and Yaoundé Gyneco-Obstetric and Pediatric Hospital (7). The detail of the contribution of each pathology center is given in Table 1. Fifty eight tumors were malignant (21.1%) while 217 were benign (78.9%). The mean age of the patients was 37.44 (SD: 54.7) years with extremes of 1 and 84 years. Mean age was 46.9 (SD: 43.13) years with extremes of 18 and 79 years in the patients with malignant tumors versus 34.9 (SD: 39.6) years with extremes of 1 and 84 years in those with benignant tumors (p = 0.03). The distribution of tumors according to age range and histology is given in Figure 1. We obtained the sequence of 135:109:30 for parotid, submandibular and accessory salivary glands respectively, thus giving a parotid/submandibular gland ratio of 1.23 (Table 2). Pleomorphic adenoma (60.36% of benign tumors and 47.7% of all tumors) was the most frequent benign tumor. The cystic adenoid carcinoma was the most frequent malignant tumor (31%of them), followed by the mucoepidermoid carcinoma (22.4%), and adenocarcinoma (19%). There were 30 cases (20%) of accessory salivary gland involvement, of which 20% were malignant tumors. The palate (66.7%), the cheek (30%) and the lips (3.3%) were the sites affected by accessory salivary gland tumors. There were 54 inflammatory pseudo tumors, representing 24.8% of benign tumors and 19.6% of the sample (Table 3). We compared our results to those of other authors. It shows a similarity between African results, contrary to Western World literature (Table 4).

Bottom Line: Pleomorphic adenoma (60.36%) was the most common benign tumor.Adenoid cystic carcinoma (31%), mucoepidermoid carcinoma (22.4%) and adenocarcinoma (19%) were the most common malignant tumors.Palate (66.7%), cheek (30%) and lips (3.3%) were the sites were the minor salivary glands were mostly involved.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine and Biomedical Sciences (FMBS) of the University of Yaoundé I, Yaoundé, Cameroon; Pathology Service of Gyneco-Obstetric and Pediatric Hospital, Yaoundé, Cameroon.

ABSTRACT

Introduction: Tumors of salivary glands are rare. According to Johns and Goldsmith in 1989, their annual incidence is less than 1/100000 without noteworthy geographical gap. But other authors suggest that their distribution may vary according to the race and geographical location. In Cameroon, existing studies give incomplete data. Hence, we underwent this study in order to draw the general profile of salivary gland tumors in Cameroon.

Methods: A retrospective study was carried out on the period spanning from January 2000 to December 2010 (11 years). It was done in nine Pathology services of different hospitals in Yaoundé, Douala and Bamenda. We consulted the archive registers of those services, retaining any patient with salivary gland tumor, whatever the histological type or location. Information gathered was the year of diagnosis, the service, the age and sex, the site of the tumor (gland) the histological type and the benign/ malignant character.

Results: We recruited a total of 275 files. Women were 56% (154/275) and men 44% (121/275) of the sample. Fifty eight tumors were malignant (21.9%) while 217 were benign (78.1%). The overall mean age was 37.44 years, with extremes between 1 and 84 years. Pleomorphic adenoma (60.36%) was the most common benign tumor. Adenoid cystic carcinoma (31%), mucoepidermoid carcinoma (22.4%) and adenocarcinoma (19%) were the most common malignant tumors. Palate (66.7%), cheek (30%) and lips (3.3%) were the sites were the minor salivary glands were mostly involved.

Conclusion: The differences with western world authors suggest a geographical variability of salivary gland tumors.

No MeSH data available.


Related in: MedlinePlus