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A review of the clinicopathologic characteristics of intestinal metaplasia in gastric mucosal biopsies.

Olaofe OO, Sabageh D, Komolafe AO - Pan Afr Med J (2016)

Bottom Line: There were 83 males (50.3%) with a mean age of 48.1 ± 18.2 SD years and 95% confidence interval (CI) of 44.1-52.1 years.There were, however, 82 females (49.6%) with a mean age of 52.5 (± 15.8 SD) years and a 95% CI of 49.0-56.0 years.In majority of patients, progression from intestinal metaplasia to gastric adenocarcinoma probably takes an average of about 7 years.

View Article: PubMed Central - PubMed

Affiliation: Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.

ABSTRACT

Introduction: Although it is a well recognized premalignant lesion of the stomach, there is a dearth of information on the clinicopathologic features of gastric intestinal metaplasia in Nigerians. It is, therefore, necessary to study these features and their possible contribution to the development of gastric carcinoma in Nigerians.

Methods: All gastric biopsies with the histo-morphologic features of intestinal metaplasia diagnosed at the department of morbid anatomy and forensic medicine, Obafemi Awolowo university teaching hospitals complex, Ile-Ife, Nigeria between January 2006 and December 2010 were used for the study.

Results: A total of 165 biopsies (21.3% of all gastric biopsies within the study period) with background chronic gastritis and intestinal metaplasia were reviewed. The mean age of patients with intestinal metaplasia was 50.3 years ± 17 standard deviation (SD) while the ages of the patients ranged from 10-100 years. There were 83 males (50.3%) with a mean age of 48.1 ± 18.2 SD years and 95% confidence interval (CI) of 44.1-52.1 years. There were, however, 82 females (49.6%) with a mean age of 52.5 (± 15.8 SD) years and a 95% CI of 49.0-56.0 years. There was no significant association between the histologic type of intestinal metaplasia and the patients' sex, age groups, severity of chronic gastritis, disease activity or degree of gastric glandular atrophy.

Conclusion: There are no statistically significant differences in the clinicopathologic characteristics of the subtypes of intestinal metaplasia. In majority of patients, progression from intestinal metaplasia to gastric adenocarcinoma probably takes an average of about 7 years.

No MeSH data available.


Related in: MedlinePlus

Box plot of patients’ age and sex
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Figure 0002: Box plot of patients’ age and sex

Mentions: Within the period under review a total of 775 cases of chronic gastritis were histologically diagnosed. However, only 165 cases (21.3%) showed histological features of intestinal metaplasia of which 137 were properly classified into complete or incomplete intestinal metaplasia. The other 28 biopsies were difficult to characterize due to severe crushing and fragmentation of the tissue sections. The mean age for the occurrence of intestinal metaplasia in gastric biopsies with background chronic gastritis was 50.3 years ± 17.1 SD while the ages of the patients ranged from 10 -100 years (Figure 1). Table 1 shows the age distribution of the subtypes of intestinal metaplasia. Although the specific types of intestinal metaplasia were not significantly associated with the age of the patients (P=0.934), most of the cases of intestinal metaplasia occurred between the ages of 30-59 years. There were 83 males (50.3%) with a mean age of 48.1 years ± 18.2 SD and a 95% Confidence Interval (CI) of 44.1-52.1 years. There were, however, 82 females (49.7%) with a mean age of 52.5 years ± 15.8 SD and a 95% CI of 49.0-56.0 years. Thus the male to female ratio was approximately 1:1. Figure 2 is a box and whisker chart showing the difference in these means and the variation around the mean. There was however, no statistically significant difference in the mean ages of both sexes (t-test of equality of means, P=0.10). There were 78 (47.3%) and 59 (35.8%) cases of incomplete and complete metaplasia respectively. The mean age of all the cases of incomplete intestinal metaplasia was 52.5 ± 16.6 years while that of complete intestinal metaplasia was 48.9 ± 17.5 years (Figure 3). There was no statistically significant difference in the mean ages for the sub-types of intestinal metaplasia (t-test of equality of means, P=0.217). Males accounted for 37 cases (47.4%) of incomplete metaplasia, while females accounted for 41 cases (52.6%). On the other hand, males accounted for 33 cases (55.9%) of complete metaplasia while females accounted for 26 cases (44.1%). histological features of intestinal metaplasia of which 137 were properly classified into complete or incomplete intestinal metaplasia. There was, however, no statistically significant association between the patients’ sex and the sub-type of intestinal metaplasia (P=0.325). Mild, moderate and marked chronic gastritis were respectively found in 10 (13.2%), 25 (32.9%) and 41 (53.9%) cases of incomplete intestinal metaplasia on one hand and in 3 (5.2%), 23 (39.7%) and 32 (55.2%) cases of complete intestinal metaplasia on the other hand. The severity of the inflammation could not be determined in 3 of the cases with intestinal metaplasia due to inadequate histologic material. The type of intestinal metaplasia was not significantly associated with the severity of chronic inflammation of the gastric mucosa (P=0.274). Mild, moderate and marked gastric glandular atrophy were found respectively in 28 (13.0%), 31 (40.3%) and 8 (10.4%) cases of incomplete intestinal metaplasia and in 13 (23.2%), 24 (42.9%) and 10 (17.9%) cases of complete intestinal metaplasia. The type of intestinal metaplasia was however, not significantly associated with the degree of gastric glandular atrophy (P=0.331). There were only 5 cases (3.0%) with moderate dysplasia.


A review of the clinicopathologic characteristics of intestinal metaplasia in gastric mucosal biopsies.

Olaofe OO, Sabageh D, Komolafe AO - Pan Afr Med J (2016)

Box plot of patients’ age and sex
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4862781&req=5

Figure 0002: Box plot of patients’ age and sex
Mentions: Within the period under review a total of 775 cases of chronic gastritis were histologically diagnosed. However, only 165 cases (21.3%) showed histological features of intestinal metaplasia of which 137 were properly classified into complete or incomplete intestinal metaplasia. The other 28 biopsies were difficult to characterize due to severe crushing and fragmentation of the tissue sections. The mean age for the occurrence of intestinal metaplasia in gastric biopsies with background chronic gastritis was 50.3 years ± 17.1 SD while the ages of the patients ranged from 10 -100 years (Figure 1). Table 1 shows the age distribution of the subtypes of intestinal metaplasia. Although the specific types of intestinal metaplasia were not significantly associated with the age of the patients (P=0.934), most of the cases of intestinal metaplasia occurred between the ages of 30-59 years. There were 83 males (50.3%) with a mean age of 48.1 years ± 18.2 SD and a 95% Confidence Interval (CI) of 44.1-52.1 years. There were, however, 82 females (49.7%) with a mean age of 52.5 years ± 15.8 SD and a 95% CI of 49.0-56.0 years. Thus the male to female ratio was approximately 1:1. Figure 2 is a box and whisker chart showing the difference in these means and the variation around the mean. There was however, no statistically significant difference in the mean ages of both sexes (t-test of equality of means, P=0.10). There were 78 (47.3%) and 59 (35.8%) cases of incomplete and complete metaplasia respectively. The mean age of all the cases of incomplete intestinal metaplasia was 52.5 ± 16.6 years while that of complete intestinal metaplasia was 48.9 ± 17.5 years (Figure 3). There was no statistically significant difference in the mean ages for the sub-types of intestinal metaplasia (t-test of equality of means, P=0.217). Males accounted for 37 cases (47.4%) of incomplete metaplasia, while females accounted for 41 cases (52.6%). On the other hand, males accounted for 33 cases (55.9%) of complete metaplasia while females accounted for 26 cases (44.1%). histological features of intestinal metaplasia of which 137 were properly classified into complete or incomplete intestinal metaplasia. There was, however, no statistically significant association between the patients’ sex and the sub-type of intestinal metaplasia (P=0.325). Mild, moderate and marked chronic gastritis were respectively found in 10 (13.2%), 25 (32.9%) and 41 (53.9%) cases of incomplete intestinal metaplasia on one hand and in 3 (5.2%), 23 (39.7%) and 32 (55.2%) cases of complete intestinal metaplasia on the other hand. The severity of the inflammation could not be determined in 3 of the cases with intestinal metaplasia due to inadequate histologic material. The type of intestinal metaplasia was not significantly associated with the severity of chronic inflammation of the gastric mucosa (P=0.274). Mild, moderate and marked gastric glandular atrophy were found respectively in 28 (13.0%), 31 (40.3%) and 8 (10.4%) cases of incomplete intestinal metaplasia and in 13 (23.2%), 24 (42.9%) and 10 (17.9%) cases of complete intestinal metaplasia. The type of intestinal metaplasia was however, not significantly associated with the degree of gastric glandular atrophy (P=0.331). There were only 5 cases (3.0%) with moderate dysplasia.

Bottom Line: There were 83 males (50.3%) with a mean age of 48.1 ± 18.2 SD years and 95% confidence interval (CI) of 44.1-52.1 years.There were, however, 82 females (49.6%) with a mean age of 52.5 (± 15.8 SD) years and a 95% CI of 49.0-56.0 years.In majority of patients, progression from intestinal metaplasia to gastric adenocarcinoma probably takes an average of about 7 years.

View Article: PubMed Central - PubMed

Affiliation: Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.

ABSTRACT

Introduction: Although it is a well recognized premalignant lesion of the stomach, there is a dearth of information on the clinicopathologic features of gastric intestinal metaplasia in Nigerians. It is, therefore, necessary to study these features and their possible contribution to the development of gastric carcinoma in Nigerians.

Methods: All gastric biopsies with the histo-morphologic features of intestinal metaplasia diagnosed at the department of morbid anatomy and forensic medicine, Obafemi Awolowo university teaching hospitals complex, Ile-Ife, Nigeria between January 2006 and December 2010 were used for the study.

Results: A total of 165 biopsies (21.3% of all gastric biopsies within the study period) with background chronic gastritis and intestinal metaplasia were reviewed. The mean age of patients with intestinal metaplasia was 50.3 years ± 17 standard deviation (SD) while the ages of the patients ranged from 10-100 years. There were 83 males (50.3%) with a mean age of 48.1 ± 18.2 SD years and 95% confidence interval (CI) of 44.1-52.1 years. There were, however, 82 females (49.6%) with a mean age of 52.5 (± 15.8 SD) years and a 95% CI of 49.0-56.0 years. There was no significant association between the histologic type of intestinal metaplasia and the patients' sex, age groups, severity of chronic gastritis, disease activity or degree of gastric glandular atrophy.

Conclusion: There are no statistically significant differences in the clinicopathologic characteristics of the subtypes of intestinal metaplasia. In majority of patients, progression from intestinal metaplasia to gastric adenocarcinoma probably takes an average of about 7 years.

No MeSH data available.


Related in: MedlinePlus