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Role of HIF1A, VEGFA and VEGFR2 SNPs in the Susceptibility and Progression of COPD in a Spanish Population.

Baz-Dávila R, Espinoza-Jiménez A, Rodríguez-Pérez Mdel C, Zulueta J, Varo N, Montejo Á, Almeida-González D, Aguirre-Jaime A, Córdoba-Lanús E, Casanova C - PLoS ONE (2016)

Bottom Line: The haplotype in which both SNPs presented the T allele confirmed the association found (OR = 0.02; 95% CI = 0.00 to 0.66; p = 0.03).Moreover, patients with COPD carrying the T allele in homozygosis in rs3025020 SNP showed higher lung function values and this association remained constant during 3 years of follow-up.In conclusion, T allele in rs833070 and rs3025020 may confer a protective effect to COPD susceptibility in a Spanish population and the association of the SNP rs3025020 with lung function may be suggesting a role for VEGF in the progression of the disease.

View Article: PubMed Central - PubMed

Affiliation: Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.

ABSTRACT
Hypoxia is involved in the development of chronic inflammatory processes. Under hypoxic conditions HIF1A, VEGF and VEGFR2 are expressed and mediate the course of the resultant disease. The aim of the present study was to define the associations between tSNPs in these genes and COPD susceptibility and progression in a Spanish cohort. The T alleles in rs3025020 and rs833070 SNPs (VEGFA gene) were less frequent in the group of COPD cases and were associated with a lower risk of developing the disease (OR = 0.60; 95% CI = 0. 39-0.93; p = 0.023 and OR = 0.60; 95% CI = 0.38-0.96; p = 0.034, respectively) under a dominant model of inheritance. The haplotype in which both SNPs presented the T allele confirmed the association found (OR = 0.02; 95% CI = 0.00 to 0.66; p = 0.03). Moreover, patients with COPD carrying the T allele in homozygosis in rs3025020 SNP showed higher lung function values and this association remained constant during 3 years of follow-up. In conclusion, T allele in rs833070 and rs3025020 may confer a protective effect to COPD susceptibility in a Spanish population and the association of the SNP rs3025020 with lung function may be suggesting a role for VEGF in the progression of the disease.

No MeSH data available.


Related in: MedlinePlus

Lung function differences between rs3025020 genotypes in patients with Chronic Obstructive Pulmonary Disease over time.FEV1 (% pred) for the three genotypes of SNP rs3025020 (VEGFA gene) over time. The presence of allele T in homozygosis determined higher values of FEV1 (% pred) respect to the other genotypes. The differences remained constant for every visit (** p-value<0.01; *** p-value<0.001) and along 3 years of follow-up (p = 0.017). The sample size for each moment was: Baseline: N = 132; 1st year: N = 118; 2nd year: N = 98 and 3rd year: N = 87.
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pone.0154998.g001: Lung function differences between rs3025020 genotypes in patients with Chronic Obstructive Pulmonary Disease over time.FEV1 (% pred) for the three genotypes of SNP rs3025020 (VEGFA gene) over time. The presence of allele T in homozygosis determined higher values of FEV1 (% pred) respect to the other genotypes. The differences remained constant for every visit (** p-value<0.01; *** p-value<0.001) and along 3 years of follow-up (p = 0.017). The sample size for each moment was: Baseline: N = 132; 1st year: N = 118; 2nd year: N = 98 and 3rd year: N = 87.

Mentions: Furthermore, COPD patients that carried the TT genotype of SNP rs3025020 presented higher lung function values overtime. We found that the presence of the minor allele T in homozygosis was significantly associated with a better lung function measured by FEV1 (% pred). This association remained constant over time when performing a longitudinal analysis of FEV1 during the 3-year follow-up period (p = 0.017) (Fig 1).


Role of HIF1A, VEGFA and VEGFR2 SNPs in the Susceptibility and Progression of COPD in a Spanish Population.

Baz-Dávila R, Espinoza-Jiménez A, Rodríguez-Pérez Mdel C, Zulueta J, Varo N, Montejo Á, Almeida-González D, Aguirre-Jaime A, Córdoba-Lanús E, Casanova C - PLoS ONE (2016)

Lung function differences between rs3025020 genotypes in patients with Chronic Obstructive Pulmonary Disease over time.FEV1 (% pred) for the three genotypes of SNP rs3025020 (VEGFA gene) over time. The presence of allele T in homozygosis determined higher values of FEV1 (% pred) respect to the other genotypes. The differences remained constant for every visit (** p-value<0.01; *** p-value<0.001) and along 3 years of follow-up (p = 0.017). The sample size for each moment was: Baseline: N = 132; 1st year: N = 118; 2nd year: N = 98 and 3rd year: N = 87.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4862690&req=5

pone.0154998.g001: Lung function differences between rs3025020 genotypes in patients with Chronic Obstructive Pulmonary Disease over time.FEV1 (% pred) for the three genotypes of SNP rs3025020 (VEGFA gene) over time. The presence of allele T in homozygosis determined higher values of FEV1 (% pred) respect to the other genotypes. The differences remained constant for every visit (** p-value<0.01; *** p-value<0.001) and along 3 years of follow-up (p = 0.017). The sample size for each moment was: Baseline: N = 132; 1st year: N = 118; 2nd year: N = 98 and 3rd year: N = 87.
Mentions: Furthermore, COPD patients that carried the TT genotype of SNP rs3025020 presented higher lung function values overtime. We found that the presence of the minor allele T in homozygosis was significantly associated with a better lung function measured by FEV1 (% pred). This association remained constant over time when performing a longitudinal analysis of FEV1 during the 3-year follow-up period (p = 0.017) (Fig 1).

Bottom Line: The haplotype in which both SNPs presented the T allele confirmed the association found (OR = 0.02; 95% CI = 0.00 to 0.66; p = 0.03).Moreover, patients with COPD carrying the T allele in homozygosis in rs3025020 SNP showed higher lung function values and this association remained constant during 3 years of follow-up.In conclusion, T allele in rs833070 and rs3025020 may confer a protective effect to COPD susceptibility in a Spanish population and the association of the SNP rs3025020 with lung function may be suggesting a role for VEGF in the progression of the disease.

View Article: PubMed Central - PubMed

Affiliation: Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.

ABSTRACT
Hypoxia is involved in the development of chronic inflammatory processes. Under hypoxic conditions HIF1A, VEGF and VEGFR2 are expressed and mediate the course of the resultant disease. The aim of the present study was to define the associations between tSNPs in these genes and COPD susceptibility and progression in a Spanish cohort. The T alleles in rs3025020 and rs833070 SNPs (VEGFA gene) were less frequent in the group of COPD cases and were associated with a lower risk of developing the disease (OR = 0.60; 95% CI = 0. 39-0.93; p = 0.023 and OR = 0.60; 95% CI = 0.38-0.96; p = 0.034, respectively) under a dominant model of inheritance. The haplotype in which both SNPs presented the T allele confirmed the association found (OR = 0.02; 95% CI = 0.00 to 0.66; p = 0.03). Moreover, patients with COPD carrying the T allele in homozygosis in rs3025020 SNP showed higher lung function values and this association remained constant during 3 years of follow-up. In conclusion, T allele in rs833070 and rs3025020 may confer a protective effect to COPD susceptibility in a Spanish population and the association of the SNP rs3025020 with lung function may be suggesting a role for VEGF in the progression of the disease.

No MeSH data available.


Related in: MedlinePlus