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Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response.

Aubrecht TG, Weil ZM, Abi Salloum B, Ariza ME, Williams M, Reader B, Glaser R, Sheridan J, Nelson RJ - J Behav Brain Sci (2015)

Bottom Line: Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome.In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection.The physical swimming stress does not alter the sickness response.

View Article: PubMed Central - HTML - PubMed

Affiliation: Departments of Neuroscience, The Ohio State University, Columbus, OH, USA.

ABSTRACT

Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome. Stress is known to influence the immune system and can exacerbate the sickness response. Although a role for psychological stress in the sickness response, particularly in combination with EBV-encoded deoxyuridine triphosphate nucleotidohydrolase (dUTPase) has been established, and the role of physical stressors in these interactions remains unspecified. In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection. We hypothesize that a chronic physical stressor will exacerbate the sickness response following EBV-encoded dUTPase injection. To test this hypothesis mice receive daily injections of EBV-encoded dUTPase or vehicle and are subjected to 15 min of swim stress each day for 14 days or left unmanipulated. On the final evening of injections mice undergo behavioral testing. EBV-encoded dUTPase injection alone produces some sickness behaviors. The physical swimming stress does not alter the sickness response.

No MeSH data available.


Related in: MedlinePlus

Anxiety- and depressive-like behaviors were similar among groups in the open field, elevated plus maze, and tail suspension test. Percent of time spent in the center of the open field on day 14 (a). Time spent on the open arm of the elevated plus maze on day 14 (b). Time spent immobile during the tail suspension test (c). All data are presented as mean (±SEM).
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Figure 4: Anxiety- and depressive-like behaviors were similar among groups in the open field, elevated plus maze, and tail suspension test. Percent of time spent in the center of the open field on day 14 (a). Time spent on the open arm of the elevated plus maze on day 14 (b). Time spent immobile during the tail suspension test (c). All data are presented as mean (±SEM).

Mentions: Anxiety-like behavior was not altered by EBV-encoded dUTPase injection (F1,36 = 0.11, p = 0.74, Figure 4(a)) or swimming (F1,36 = 0.21, p = 0.65, Figure 4(a)) assessed by time spent in the center of the open field.


Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response.

Aubrecht TG, Weil ZM, Abi Salloum B, Ariza ME, Williams M, Reader B, Glaser R, Sheridan J, Nelson RJ - J Behav Brain Sci (2015)

Anxiety- and depressive-like behaviors were similar among groups in the open field, elevated plus maze, and tail suspension test. Percent of time spent in the center of the open field on day 14 (a). Time spent on the open arm of the elevated plus maze on day 14 (b). Time spent immobile during the tail suspension test (c). All data are presented as mean (±SEM).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4862656&req=5

Figure 4: Anxiety- and depressive-like behaviors were similar among groups in the open field, elevated plus maze, and tail suspension test. Percent of time spent in the center of the open field on day 14 (a). Time spent on the open arm of the elevated plus maze on day 14 (b). Time spent immobile during the tail suspension test (c). All data are presented as mean (±SEM).
Mentions: Anxiety-like behavior was not altered by EBV-encoded dUTPase injection (F1,36 = 0.11, p = 0.74, Figure 4(a)) or swimming (F1,36 = 0.21, p = 0.65, Figure 4(a)) assessed by time spent in the center of the open field.

Bottom Line: Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome.In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection.The physical swimming stress does not alter the sickness response.

View Article: PubMed Central - HTML - PubMed

Affiliation: Departments of Neuroscience, The Ohio State University, Columbus, OH, USA.

ABSTRACT

Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome. Stress is known to influence the immune system and can exacerbate the sickness response. Although a role for psychological stress in the sickness response, particularly in combination with EBV-encoded deoxyuridine triphosphate nucleotidohydrolase (dUTPase) has been established, and the role of physical stressors in these interactions remains unspecified. In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection. We hypothesize that a chronic physical stressor will exacerbate the sickness response following EBV-encoded dUTPase injection. To test this hypothesis mice receive daily injections of EBV-encoded dUTPase or vehicle and are subjected to 15 min of swim stress each day for 14 days or left unmanipulated. On the final evening of injections mice undergo behavioral testing. EBV-encoded dUTPase injection alone produces some sickness behaviors. The physical swimming stress does not alter the sickness response.

No MeSH data available.


Related in: MedlinePlus