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Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response.

Aubrecht TG, Weil ZM, Abi Salloum B, Ariza ME, Williams M, Reader B, Glaser R, Sheridan J, Nelson RJ - J Behav Brain Sci (2015)

Bottom Line: Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome.In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection.The physical swimming stress does not alter the sickness response.

View Article: PubMed Central - HTML - PubMed

Affiliation: Departments of Neuroscience, The Ohio State University, Columbus, OH, USA.

ABSTRACT

Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome. Stress is known to influence the immune system and can exacerbate the sickness response. Although a role for psychological stress in the sickness response, particularly in combination with EBV-encoded deoxyuridine triphosphate nucleotidohydrolase (dUTPase) has been established, and the role of physical stressors in these interactions remains unspecified. In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection. We hypothesize that a chronic physical stressor will exacerbate the sickness response following EBV-encoded dUTPase injection. To test this hypothesis mice receive daily injections of EBV-encoded dUTPase or vehicle and are subjected to 15 min of swim stress each day for 14 days or left unmanipulated. On the final evening of injections mice undergo behavioral testing. EBV-encoded dUTPase injection alone produces some sickness behaviors. The physical swimming stress does not alter the sickness response.

No MeSH data available.


Related in: MedlinePlus

Data are presented as mean (±SEM) representing total food intake, milk intake (during three hour exposure daily), and change in body mass over all 14 days. Total food intake was not altered by EBV-encoded dUTPase injection (F1,36 = 0.19, p = 0.67, (a)) or swimming (F1,36 = 0.86, p = 0.36, (a)).Total milk intake was not altered by EBV-encoded dUTPase injection (F1,36 = 1.04, p = 0.31, (b)) or swimming (F1,36 = 1.16, p = 0.29, (b)). Change in body mass was not altered by EBV-encoded dUTPase injection (F1,36 = 0.16, p = 0.69, (c)) or swimming (F1,36 = 1.07, p = 0.31, (c)).
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Figure 3: Data are presented as mean (±SEM) representing total food intake, milk intake (during three hour exposure daily), and change in body mass over all 14 days. Total food intake was not altered by EBV-encoded dUTPase injection (F1,36 = 0.19, p = 0.67, (a)) or swimming (F1,36 = 0.86, p = 0.36, (a)).Total milk intake was not altered by EBV-encoded dUTPase injection (F1,36 = 1.04, p = 0.31, (b)) or swimming (F1,36 = 1.16, p = 0.29, (b)). Change in body mass was not altered by EBV-encoded dUTPase injection (F1,36 = 0.16, p = 0.69, (c)) or swimming (F1,36 = 1.07, p = 0.31, (c)).

Mentions: Total food intake was not altered by EBV-encoded dUTPase injection (F1,36 = 0.19, p = 0.67, Figure 3(a)) or swimming (F1,36 = 0.86, p = 0.36, Figure 3(a)).


Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response.

Aubrecht TG, Weil ZM, Abi Salloum B, Ariza ME, Williams M, Reader B, Glaser R, Sheridan J, Nelson RJ - J Behav Brain Sci (2015)

Data are presented as mean (±SEM) representing total food intake, milk intake (during three hour exposure daily), and change in body mass over all 14 days. Total food intake was not altered by EBV-encoded dUTPase injection (F1,36 = 0.19, p = 0.67, (a)) or swimming (F1,36 = 0.86, p = 0.36, (a)).Total milk intake was not altered by EBV-encoded dUTPase injection (F1,36 = 1.04, p = 0.31, (b)) or swimming (F1,36 = 1.16, p = 0.29, (b)). Change in body mass was not altered by EBV-encoded dUTPase injection (F1,36 = 0.16, p = 0.69, (c)) or swimming (F1,36 = 1.07, p = 0.31, (c)).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4862656&req=5

Figure 3: Data are presented as mean (±SEM) representing total food intake, milk intake (during three hour exposure daily), and change in body mass over all 14 days. Total food intake was not altered by EBV-encoded dUTPase injection (F1,36 = 0.19, p = 0.67, (a)) or swimming (F1,36 = 0.86, p = 0.36, (a)).Total milk intake was not altered by EBV-encoded dUTPase injection (F1,36 = 1.04, p = 0.31, (b)) or swimming (F1,36 = 1.16, p = 0.29, (b)). Change in body mass was not altered by EBV-encoded dUTPase injection (F1,36 = 0.16, p = 0.69, (c)) or swimming (F1,36 = 1.07, p = 0.31, (c)).
Mentions: Total food intake was not altered by EBV-encoded dUTPase injection (F1,36 = 0.19, p = 0.67, Figure 3(a)) or swimming (F1,36 = 0.86, p = 0.36, Figure 3(a)).

Bottom Line: Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome.In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection.The physical swimming stress does not alter the sickness response.

View Article: PubMed Central - HTML - PubMed

Affiliation: Departments of Neuroscience, The Ohio State University, Columbus, OH, USA.

ABSTRACT

Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome. Stress is known to influence the immune system and can exacerbate the sickness response. Although a role for psychological stress in the sickness response, particularly in combination with EBV-encoded deoxyuridine triphosphate nucleotidohydrolase (dUTPase) has been established, and the role of physical stressors in these interactions remains unspecified. In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection. We hypothesize that a chronic physical stressor will exacerbate the sickness response following EBV-encoded dUTPase injection. To test this hypothesis mice receive daily injections of EBV-encoded dUTPase or vehicle and are subjected to 15 min of swim stress each day for 14 days or left unmanipulated. On the final evening of injections mice undergo behavioral testing. EBV-encoded dUTPase injection alone produces some sickness behaviors. The physical swimming stress does not alter the sickness response.

No MeSH data available.


Related in: MedlinePlus