Limits...
Pediatric spinal glioblastoma of the conus medullaris: a case report of long survival.

Cacchione A, Mastronuzzi A, Cefalo MG, Colafati GS, Diomedi-Camassei F, Rizzi M, De Benedictis A, Carai A - Chin J Cancer (2016)

Bottom Line: These tumors are associated with severe disability and poor prognosis.We describe the peculiar characteristics of this rare condition in pediatric oncology.We also provide an overview of current multidisciplinary therapeutic approaches and prognostic factors for this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric Hematology-Oncology, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165, Rome, Italy. antonella.cacchione@opbg.net.

ABSTRACT
High-grade gliomas of the spinal cord represent a rare entity in children. Their biology, behavior, and controversial treatment options have been discussed in a few pediatric cases. These tumors are associated with severe disability and poor prognosis. We report a case of a 4-year-old child diagnosed with an isolated glioblastoma multiforme of the conus medullaris. The patient underwent subtotal surgical excision, followed by adjuvant radiotherapy and oral chemotherapy. He is alive with mild neurologic deficits at 52 months after diagnosis. We describe the peculiar characteristics of this rare condition in pediatric oncology. We also provide an overview of current multidisciplinary therapeutic approaches and prognostic factors for this disease.

No MeSH data available.


Related in: MedlinePlus

Postoperative MRI of the boy with spinal GBM of the conus medullaris. Postoperative MRI shows a subtotal resection of the primary lesion and leptomeningeal involvement at the level of the conus medullaris and cauda equine (arrows) (a); after Gd injection, there is no contrast enhancement (arrows) (b). Two years after surgery, MRI shows the absence of relapses (c) and stable persistence of the previously documented enhancement along the right anterolateral conus medullaris (level D10-D12) and along the cauda equina (d)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4862181&req=5

Fig2: Postoperative MRI of the boy with spinal GBM of the conus medullaris. Postoperative MRI shows a subtotal resection of the primary lesion and leptomeningeal involvement at the level of the conus medullaris and cauda equine (arrows) (a); after Gd injection, there is no contrast enhancement (arrows) (b). Two years after surgery, MRI shows the absence of relapses (c) and stable persistence of the previously documented enhancement along the right anterolateral conus medullaris (level D10-D12) and along the cauda equina (d)

Mentions: Microsurgical subtotal excision was performed with intraoperative neurophysiologic monitoring. After opening the dura, a brownish-red, highly vascularized solid mass appeared. At the end of the procedure, the excision appeared to be subtotal, as confirmed by postoperative MRI (Fig. 2a, b). The patient’s clinical status worsened after surgery, with worse paraparesis on the right side. Hypoesthesia with a D11 level and urinary incontinence were also observed. Pathology was suggestive of GBM (Fig. 3).Fig. 2


Pediatric spinal glioblastoma of the conus medullaris: a case report of long survival.

Cacchione A, Mastronuzzi A, Cefalo MG, Colafati GS, Diomedi-Camassei F, Rizzi M, De Benedictis A, Carai A - Chin J Cancer (2016)

Postoperative MRI of the boy with spinal GBM of the conus medullaris. Postoperative MRI shows a subtotal resection of the primary lesion and leptomeningeal involvement at the level of the conus medullaris and cauda equine (arrows) (a); after Gd injection, there is no contrast enhancement (arrows) (b). Two years after surgery, MRI shows the absence of relapses (c) and stable persistence of the previously documented enhancement along the right anterolateral conus medullaris (level D10-D12) and along the cauda equina (d)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4862181&req=5

Fig2: Postoperative MRI of the boy with spinal GBM of the conus medullaris. Postoperative MRI shows a subtotal resection of the primary lesion and leptomeningeal involvement at the level of the conus medullaris and cauda equine (arrows) (a); after Gd injection, there is no contrast enhancement (arrows) (b). Two years after surgery, MRI shows the absence of relapses (c) and stable persistence of the previously documented enhancement along the right anterolateral conus medullaris (level D10-D12) and along the cauda equina (d)
Mentions: Microsurgical subtotal excision was performed with intraoperative neurophysiologic monitoring. After opening the dura, a brownish-red, highly vascularized solid mass appeared. At the end of the procedure, the excision appeared to be subtotal, as confirmed by postoperative MRI (Fig. 2a, b). The patient’s clinical status worsened after surgery, with worse paraparesis on the right side. Hypoesthesia with a D11 level and urinary incontinence were also observed. Pathology was suggestive of GBM (Fig. 3).Fig. 2

Bottom Line: These tumors are associated with severe disability and poor prognosis.We describe the peculiar characteristics of this rare condition in pediatric oncology.We also provide an overview of current multidisciplinary therapeutic approaches and prognostic factors for this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric Hematology-Oncology, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165, Rome, Italy. antonella.cacchione@opbg.net.

ABSTRACT
High-grade gliomas of the spinal cord represent a rare entity in children. Their biology, behavior, and controversial treatment options have been discussed in a few pediatric cases. These tumors are associated with severe disability and poor prognosis. We report a case of a 4-year-old child diagnosed with an isolated glioblastoma multiforme of the conus medullaris. The patient underwent subtotal surgical excision, followed by adjuvant radiotherapy and oral chemotherapy. He is alive with mild neurologic deficits at 52 months after diagnosis. We describe the peculiar characteristics of this rare condition in pediatric oncology. We also provide an overview of current multidisciplinary therapeutic approaches and prognostic factors for this disease.

No MeSH data available.


Related in: MedlinePlus