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The physiological and perceptual effects of plant extracts (Catha Edulis Forsk) during sustained exercise.

Sallam MA, Sheikh KA, Baxendale R, Azam MN, El-Setouhy M - Subst Abuse Treat Prev Policy (2016)

Bottom Line: According to study results, khat dramatically decreased time taken to complete a 10 km cycling time trail (p < 0.05), and significantly increased heart rate (p < 0.05) and tympanic temperature (p < 0.01).Thus, khat produces the same effects which lead to the banning of amphetamine.These findings conform & endorse the recent prohibition of cathinone by the World Anti-Doping Agency (WADA, 2014).

View Article: PubMed Central - PubMed

Affiliation: Substance Abuse Research Center, Jazan University, Jazan, Kingdom of Saudi Arabia.

ABSTRACT

Background: Khat (Catha Edulis Forsk) is a natural psychoactive substance that contains addictive substances such as Cathine and Cathinone which have similar structure and action to amphetamine. This substance has been suggested that it can decrease perceived exertion and thus improve performance. There is no study in the literature regarding the effect of khat on exercise performance. Therefore, the aim of this study is to find out whether khat leaves can decrease perceived exertion in humans.

Methods: This study is an experimental crossover study conducted at the Substance Abuse Research Centre in Jazan University, Saudi Arabia. Twenty one healthy volunteers were randomly assigned into two experiment trials. Each volunteer visited the lab three times. The first visit was a familiarization session about the nature of the study and the equipment. On the second visit, 45 min before the experiment volunteers ingested either 33 ml of fruit juice (placebo) or the juice mixed with 45 g of ground khat leaves. Then the participants were instructed to perform a 10 Km cycling on an ergometer and recorded the following physiological variables repeatedly on every 5 min of cycling: heart rate, time to complete 10 km cycling, tympanic temperature, and perceived exertion rate. On the third visit a crossover trial was conducted one week after the second visit; then the same cycling test was performed and the same variables were recorded as the second visit. The experimental protocol was reviewed and approved by Research Ethical Committee of the Medical Research Centre, Jazan University.

Results: According to study results, khat dramatically decreased time taken to complete a 10 km cycling time trail (p < 0.05), and significantly increased heart rate (p < 0.05) and tympanic temperature (p < 0.01). However, khat did not reduce participant's perceived exertion during the physical trial. The Bonferrini simultaneous confidence intervals using multivariate Hotelling's T(2) was performed to test the significance of the mean vectors for the placebo group and the Khat group and found that groups are statistically significant.

Conclusions: Khat showed a clear enhancing effect on physical performance. The most parsimonious explanation for this effect is that, like the related amphetamines, cathine/cathinone act as stimulants to increase the capacity to perform exercise. Thus, khat produces the same effects which lead to the banning of amphetamine. These findings conform & endorse the recent prohibition of cathinone by the World Anti-Doping Agency (WADA, 2014).

No MeSH data available.


Related in: MedlinePlus

Shows the CompuTrainer_TimeTrail.3 dc course and the distance of this course
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Related In: Results  -  Collection

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Fig2: Shows the CompuTrainer_TimeTrail.3 dc course and the distance of this course

Mentions: The test used a RacerMate CompuTrainer cycle ergometer to provide a simulation of a 10 km time trial (http://www.racermateinc.com/computrainer/). The ergometer is controlled by a laptop computer and the software delivers specific load to replicate ascents, and descents. The CompuTrainer_TimeTrail.3 dc course was used for tests. The distance of this course is 10 km and it contains mix of climbs and descents. The Computrainer screen simulates the participants during the experiment, where the screen shows the performance of the competitors during the race time. The Computrainer screen is shown in Fig. 2.Fig. 2


The physiological and perceptual effects of plant extracts (Catha Edulis Forsk) during sustained exercise.

Sallam MA, Sheikh KA, Baxendale R, Azam MN, El-Setouhy M - Subst Abuse Treat Prev Policy (2016)

Shows the CompuTrainer_TimeTrail.3 dc course and the distance of this course
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4862078&req=5

Fig2: Shows the CompuTrainer_TimeTrail.3 dc course and the distance of this course
Mentions: The test used a RacerMate CompuTrainer cycle ergometer to provide a simulation of a 10 km time trial (http://www.racermateinc.com/computrainer/). The ergometer is controlled by a laptop computer and the software delivers specific load to replicate ascents, and descents. The CompuTrainer_TimeTrail.3 dc course was used for tests. The distance of this course is 10 km and it contains mix of climbs and descents. The Computrainer screen simulates the participants during the experiment, where the screen shows the performance of the competitors during the race time. The Computrainer screen is shown in Fig. 2.Fig. 2

Bottom Line: According to study results, khat dramatically decreased time taken to complete a 10 km cycling time trail (p < 0.05), and significantly increased heart rate (p < 0.05) and tympanic temperature (p < 0.01).Thus, khat produces the same effects which lead to the banning of amphetamine.These findings conform & endorse the recent prohibition of cathinone by the World Anti-Doping Agency (WADA, 2014).

View Article: PubMed Central - PubMed

Affiliation: Substance Abuse Research Center, Jazan University, Jazan, Kingdom of Saudi Arabia.

ABSTRACT

Background: Khat (Catha Edulis Forsk) is a natural psychoactive substance that contains addictive substances such as Cathine and Cathinone which have similar structure and action to amphetamine. This substance has been suggested that it can decrease perceived exertion and thus improve performance. There is no study in the literature regarding the effect of khat on exercise performance. Therefore, the aim of this study is to find out whether khat leaves can decrease perceived exertion in humans.

Methods: This study is an experimental crossover study conducted at the Substance Abuse Research Centre in Jazan University, Saudi Arabia. Twenty one healthy volunteers were randomly assigned into two experiment trials. Each volunteer visited the lab three times. The first visit was a familiarization session about the nature of the study and the equipment. On the second visit, 45 min before the experiment volunteers ingested either 33 ml of fruit juice (placebo) or the juice mixed with 45 g of ground khat leaves. Then the participants were instructed to perform a 10 Km cycling on an ergometer and recorded the following physiological variables repeatedly on every 5 min of cycling: heart rate, time to complete 10 km cycling, tympanic temperature, and perceived exertion rate. On the third visit a crossover trial was conducted one week after the second visit; then the same cycling test was performed and the same variables were recorded as the second visit. The experimental protocol was reviewed and approved by Research Ethical Committee of the Medical Research Centre, Jazan University.

Results: According to study results, khat dramatically decreased time taken to complete a 10 km cycling time trail (p < 0.05), and significantly increased heart rate (p < 0.05) and tympanic temperature (p < 0.01). However, khat did not reduce participant's perceived exertion during the physical trial. The Bonferrini simultaneous confidence intervals using multivariate Hotelling's T(2) was performed to test the significance of the mean vectors for the placebo group and the Khat group and found that groups are statistically significant.

Conclusions: Khat showed a clear enhancing effect on physical performance. The most parsimonious explanation for this effect is that, like the related amphetamines, cathine/cathinone act as stimulants to increase the capacity to perform exercise. Thus, khat produces the same effects which lead to the banning of amphetamine. These findings conform & endorse the recent prohibition of cathinone by the World Anti-Doping Agency (WADA, 2014).

No MeSH data available.


Related in: MedlinePlus