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Microwave-Assisted Preparation of Hydrogel-Forming Microneedle Arrays for Transdermal Drug Delivery Applications.

Larrañeta E, Lutton RE, Brady AJ, Vicente-Pérez EM, Woolfson AD, Thakur RR, Donnelly RF - Macromol Mater Eng (2015)

Bottom Line: Polymeric MN arrays were prepared to compare conventional process with the novel MW-assisted crosslinking method.The effects of the crosslinking process on the properties of these materials were also evaluated.The results suggest that MN arrays prepared using the MW assisted process had equivalent properties to those prepared conventionally but can be produced 30 times faster.

View Article: PubMed Central - PubMed

Affiliation: Chair in Pharmaceutical Technology School of Pharmacy Queens University Belfast, Medical Biology Centre 97 Lisburn Road Belfast BT9 7BL UK.

ABSTRACT

1A microwave (MW)-assisted crosslinking process to prepare hydrogel-forming microneedle (MN) arrays was evaluated. Conventionally, such MN arrays are prepared using processes that includes a thermal crosslinking step. Polymeric MN arrays were prepared using poly(methyl vinyl ether-alt-maleic acid) crosslinked by reaction with poly(ethylene glycol) over 24 h at 80 °C. Polymeric MN arrays were prepared to compare conventional process with the novel MW-assisted crosslinking method. Infrared spectroscopy was used to evaluate the crosslinking degree, evaluating the area of the carbonyl peaks (2000-1500 cm(-1)). It was shown that, by using the MW-assisted process, MN with a similar crosslinking degree to those prepared conventionally can be obtained in only 45 min. The effects of the crosslinking process on the properties of these materials were also evaluated. For this purpose swelling kinetics, mechanical characterisation, and insertion studies were performed. The results suggest that MN arrays prepared using the MW assisted process had equivalent properties to those prepared conventionally but can be produced 30 times faster. Finally, an in vitro caffeine permeation across excised porcine skin was performed using conventional and MW-prepared MN arrays. The release profiles obtained can be considered equivalent, delivering in both cases 3000-3500 μg of caffeine after 24 h.

No MeSH data available.


Related in: MedlinePlus

Baseplate fracture force (a) and MN compressive stiffness (b) as a function of the crosslinking time for hydrogels prepared using the conventional method (Means ± SD, n ≥ 3). Insertion profile in Parafilm for MN prepared using different crosslinking times following the conventional oven process (Means ± SD, n = 3) (c). Baseplate fracture force (d) and MN compressive stiffness (e) as a function of the crosslinking time for hydrogels prepared using the novel MW method (Means ± SD, n ≥ 3). Insertion profile in Parafilm® for MN prepared using different crosslinking times following the MW process (f). (Means ± SD, n = 3).
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mame201500016-fig-0004: Baseplate fracture force (a) and MN compressive stiffness (b) as a function of the crosslinking time for hydrogels prepared using the conventional method (Means ± SD, n ≥ 3). Insertion profile in Parafilm for MN prepared using different crosslinking times following the conventional oven process (Means ± SD, n = 3) (c). Baseplate fracture force (d) and MN compressive stiffness (e) as a function of the crosslinking time for hydrogels prepared using the novel MW method (Means ± SD, n ≥ 3). Insertion profile in Parafilm® for MN prepared using different crosslinking times following the MW process (f). (Means ± SD, n = 3).

Mentions: Subsequently mechanical properties of the material were evaluated. The mechanical resistance of the BP was tested by applying a three point bending test.38 The fracture force of BP increased slightly when the material was crosslinked Figure 4(a) (p < 0.05). Nevertheless there were no significant differences between the obtained fracture forces for the BP crosslinked during 18 and 30 h (p > 0.05).


Microwave-Assisted Preparation of Hydrogel-Forming Microneedle Arrays for Transdermal Drug Delivery Applications.

Larrañeta E, Lutton RE, Brady AJ, Vicente-Pérez EM, Woolfson AD, Thakur RR, Donnelly RF - Macromol Mater Eng (2015)

Baseplate fracture force (a) and MN compressive stiffness (b) as a function of the crosslinking time for hydrogels prepared using the conventional method (Means ± SD, n ≥ 3). Insertion profile in Parafilm for MN prepared using different crosslinking times following the conventional oven process (Means ± SD, n = 3) (c). Baseplate fracture force (d) and MN compressive stiffness (e) as a function of the crosslinking time for hydrogels prepared using the novel MW method (Means ± SD, n ≥ 3). Insertion profile in Parafilm® for MN prepared using different crosslinking times following the MW process (f). (Means ± SD, n = 3).
© Copyright Policy - creativeCommonsBy
Related In: Results  -  Collection

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mame201500016-fig-0004: Baseplate fracture force (a) and MN compressive stiffness (b) as a function of the crosslinking time for hydrogels prepared using the conventional method (Means ± SD, n ≥ 3). Insertion profile in Parafilm for MN prepared using different crosslinking times following the conventional oven process (Means ± SD, n = 3) (c). Baseplate fracture force (d) and MN compressive stiffness (e) as a function of the crosslinking time for hydrogels prepared using the novel MW method (Means ± SD, n ≥ 3). Insertion profile in Parafilm® for MN prepared using different crosslinking times following the MW process (f). (Means ± SD, n = 3).
Mentions: Subsequently mechanical properties of the material were evaluated. The mechanical resistance of the BP was tested by applying a three point bending test.38 The fracture force of BP increased slightly when the material was crosslinked Figure 4(a) (p < 0.05). Nevertheless there were no significant differences between the obtained fracture forces for the BP crosslinked during 18 and 30 h (p > 0.05).

Bottom Line: Polymeric MN arrays were prepared to compare conventional process with the novel MW-assisted crosslinking method.The effects of the crosslinking process on the properties of these materials were also evaluated.The results suggest that MN arrays prepared using the MW assisted process had equivalent properties to those prepared conventionally but can be produced 30 times faster.

View Article: PubMed Central - PubMed

Affiliation: Chair in Pharmaceutical Technology School of Pharmacy Queens University Belfast, Medical Biology Centre 97 Lisburn Road Belfast BT9 7BL UK.

ABSTRACT

1A microwave (MW)-assisted crosslinking process to prepare hydrogel-forming microneedle (MN) arrays was evaluated. Conventionally, such MN arrays are prepared using processes that includes a thermal crosslinking step. Polymeric MN arrays were prepared using poly(methyl vinyl ether-alt-maleic acid) crosslinked by reaction with poly(ethylene glycol) over 24 h at 80 °C. Polymeric MN arrays were prepared to compare conventional process with the novel MW-assisted crosslinking method. Infrared spectroscopy was used to evaluate the crosslinking degree, evaluating the area of the carbonyl peaks (2000-1500 cm(-1)). It was shown that, by using the MW-assisted process, MN with a similar crosslinking degree to those prepared conventionally can be obtained in only 45 min. The effects of the crosslinking process on the properties of these materials were also evaluated. For this purpose swelling kinetics, mechanical characterisation, and insertion studies were performed. The results suggest that MN arrays prepared using the MW assisted process had equivalent properties to those prepared conventionally but can be produced 30 times faster. Finally, an in vitro caffeine permeation across excised porcine skin was performed using conventional and MW-prepared MN arrays. The release profiles obtained can be considered equivalent, delivering in both cases 3000-3500 μg of caffeine after 24 h.

No MeSH data available.


Related in: MedlinePlus